Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I (2007) Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiol Aging 28(8):1148–1162. https://doi.org/10.1016/j.neurobiolaging.2006.05.036 Wei ZH, He QB, Wang H et al. (2007) Meta-analysis: the efficacy of nootropic agent Cerebrolysin in the treatment of Alzheimer's disease. Journal of neural transmission 114, 629-634.

Alvarez XA, Sampedro C, Figueroa J, Tellado I, Gonzalez A, Garcia-Fantini M, Cacabelos R, Muresanu D, Moessler H (2008) Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate-severe traumatic brain injury. J Neural Transm (Vienna) 115(5):683–692. https://doi.org/10.1007/s00702-008-0024-9 Another significant advantage of Cerebrolysin is its neuroprotective properties. By protecting neurons from damage and promoting their growth, this supplement may help prevent age-related cognitive decline. This makes it an excellent choice for individuals looking to maintain their mental sharpness as they age.

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Heiss (2012) Cerebrolysin in Patients With Acute Ischemic Stroke in Asia Results of a Double-Blind, Placebo-Controlled Randomized Trial https://www.ncbi.nlm.nih.gov/pubmed/22282884 Guekht et al (2011) Cerebrolysin in Vascular Dementia: Improvement of Clinical Outcome in a Randomized, Double-Blind, Placebo-Controlled Multicenter Trial https://www.ncbi.nlm.nih.gov/pubmed/20656516

Plosker GL, Gauthier S (2009) Cerebrolysin: a review of its use in dementia. Drugs Aging 26(11):893–915. https://doi.org/10.2165/11203320-000000000-00000 Though a lot of controversy surrounds the role of amyloid-beta in conditions like Alzheimer’s disease, there is no doubt that the amount of amyloid beta in the brain directly correlates with the level of dysfunction in the disease. Research shows that in addition to producing clinical cognitive effects, Cerebrolysin decreases amyloid-beta production by regulating one of its precursors[6]. Both the timing and magnitude of this decrease correspond with changes in the severity of symptoms, suggesting that whatever effect Cerebrolysin is having, it is impacting both clinical measures and amyloid-beta concentrations through some common mechanism.

What is the Optimal Cerebrolysin Dosage?

Cerebrolysin has an excellent safety record. Unless taken in large amounts (>10 ml), adverse reactions are mild and rare.

Glial Cell Line-Derived Neurotrophic Factor: GDNF is a peptide in humans that promotes the survival of neurons and is made by the cells that support them. GDNF is especially important in protecting the neurons that produce dopamine and motor neurons. It has been shown to decrease the loss of neurons during development. It might potentially be useful in the treatment or prevention of Parkinson’s disease and amyotrophic lateral sclerosis (ALS). It is also important in regulating kidney and sperm development and has been shown to speed up the clearance of alcohol from the body.Cerebrolysin is reported to lose its effectiveness when used for longer than necessary. However, there are anecdotal cases of Cerebrolysin causing anxiety, headaches, and aches in the body when the medication brings no benefit any longer.

J. Mahmoudi et al., “Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats,” Brain Res. Bull., vol. 140, pp. 197–204, Jun. 2018, doi: 10.1016/j.brainresbull.2018.05.008. Acute conditions (ischemic stroke, traumatic brain injury, brain surgery complications): recommended dose is 10ml-50ml.Alvarez et al (2008) Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury https://www.ncbi.nlm.nih.gov/pubmed/18273537 Cerebrolysin is a combination of peptides and neurotrophins for enhancing the regeneration of neurons, neural plasticity, and neural protection during neurological illnesses, such as dementia and traumatic brain injuries. It is a neuropeptide drug formed from a series of biochemical and enzymatic reactions on porcine brain proteins. The ultimate product that is formed after a series of reactions has a low molecular weight and increased ability to cross the blood-brain barrier. Chen S-D, Yang J-L, Hwang W-C, Yang D-I (2018) Emerging roles of sonic hedgehog in adult neurological diseases: neurogenesis and beyond. Int J Mol Sci 19(8). https://doi.org/10.3390/ijms19082423