Participants were included if they met the following criteria: aged 18 to 75 years; pressure ulcers were at stage III or IV according to the european pressure ulcer advisory panel/national pressure ulcer advisory panel (NPUAP) guidelines [12]; and at least 1 pressure ulcer. 2.3.2 Exclusion criteria High temperatures or excessive handling may alter the consistency of the ointment. This will not change its effectiveness. The name of the ointment indicates two important protocols to be adopted when using this product to heal a wide range of skin wounds.

Moist exposed burn ointment (MEBO) is an oil-based ointment that contains sesame oil, beta-sitosterol, berberine, and other small quantities of plant ingredients [ 2] developed at the China National Science and Technology Centre in Beijing in 1989 [ 3]. The main ingredient of MEBO is beta-sitosterol, which has been shown to have anti-inflammatory effects, [ 4] and berberine, which has antimicrobial effects [ 4]. Laboratory tests have indicated that MEBO was not a mucocutaneous irritant nor was it orally toxic to rats; repeated cutaneous patch tests in humans did not show any potential for dermal irritation or sensitization [ 5]. Clinical and experimental investigations have shown that MEBO has analgesic and antimicrobial effects, and reduces water evaporation from the burn surface [ 6– 12]. Clinical studies have found that MEBO promotes debridement, epithelial repair and is associated with better scar quality [ 6– 17]. In three consecutively conducted clinical studies, Atiyeh et al., found that the MEBO exhibited a beneficial prophylactic effect on primary and secondary wound healing with scar quality superior in wounds treated with MEBO [10.11.15]. In a prospective comparative study comparing healing with MEBO to conventional occlusive dressings, the biologic healing with MEBO, as determined by trans-epidermal water loss (TEWL) measurements, occurred at an extremely significant earlier stage and was associated with better scar quality [ 16]. Shea butter originates from the shea tree and is an active ingredient in moisturizing creams and body and face creams due to its moisturizing and anti-inflammatory properties as well as its ability to heal scars. Qiao HB: Clinical report of 191 cases of burn and scald treated with moist exposed therapy. The Chinese Journal of Burns, Wounds & Surface Ulcer. 1991, 4: 25-26. [article in Chinese] Atiyeh BS, Amm CA, El Musa KA: Improved scar quality following primary and secondary healing of cutaneous wounds. Aesthetic Plast Surg. 2003, 27: 411-7. 10.1007/s00266-003-3049-3. Yan R, Zhu M, Zhong J: Effects of "moist burn ointment-mei bao" on production of IL-2 in burn rats and its clinical problems. Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 1994, 10: 15-18. [article in Chinese]aDepartment of Medical Science Institute of Harbin, the First Hospital of Harbin, Harbin Medical University, Harbin Sheets may also be more convenient than gel and offer the same benefits. A meta-analysis found that silicone sheets were comparable in effectiveness to gel. The sample size was determined during the 1rst year of the study as follows: The primary outcomes on which this study was powered were hospitalization days and the time of 50% wound healing. We had undertaken a pilot work to estimate effect sizes. It is known that, pilot studies offer many advantages in the estimation of an informed effect size target for power calculations [ 30]. The pilot work was carried out on 50 subjects. These 50 patients were the first (randomized) patients included in the study, so the study started, and then during the process it was decided on how many patients were still needed.

American Academy of Dermatology. (2018). The use of silicone gel to enhance skin wound healing by secondary intention following tumor excision on the scalp and extremities: a descriptive study.Exclusion criteria were as follows: (1) patients with dysfunction of the heart, liver, kidney, and other organs; (2) ulcers caused by thromboangiitis obliterans and atherosclerosis of lower limbs; (3) patients with poor blood glucose control; (4) patients with systemic infection; (5) patients with hypoproteinemia and moderate and severe anemia; (6) patients whose data were incomplete. 3. Methods Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients. Methods: Sixty-seven patients completed the study. After 2 months of treatment, the difference of mean change from the baseline was greater for MEBO (vs placebo) for WSA mean (SD) −6.0 (−8.8, −3.3), PUSH Tool −2.6 (−4.7, −1.5), and VAS score −2.9 (−4.4, −1.7). On the basis of the questionnaire, the pressure ulcers were “completely healed” (50.0% vs 16.7%) ( P< .05) in patients after 2 months of treatment with MEBO versus placebo. No major adverse effects were found in the 2 groups. Conclusion: