The electron donor ability is reported to be the main mechanism of the antioxidant activity of phenolic compounds [ 43].

mL of trichloroacetic acid (10% w/ v) solution was added, and the mixture was centrifuged at 3000 rpm for 5 min. After centrifugation for 5 min at 3000 rpm, the absorbance of the organic layer was measured at 532 nm. wounds, burnsreduces scars from fistulas, episiotomies, trauma or surgery, grafting, radioepithelitis. Further fractionation of the extract could probably be carried out to simplify the composition of the formulation, but without taking a toll on its efficiency. The 1H NMR fingerprint of the extract was recorded using a Bruker AV-500 MHz instrument (Karlsruhe, Germany).Rats were anesthetized by a ketamine–xylazine injection (80 mg kg −1:10 mg kg −1) intraperitoneally. Madecassol is prepared from the extract of the Centella Asiatica plant, a member of the Umbelliferae family. Madecassol cream is a medical cream containing an antibiotic neomycin and anti-inflammatory hydrocortisone, used to reduce inflammation, treat minor abrasions, post-operative cuts, and chest cracks.

Madecassol cream, which is especially used in the treatment of wounds, burns, skin blemishes, acne scars and stretch marks, is a drug recommended for use by experts as it has no side effects on pregnant women and breastfeeding mothers.The study was undertaken since the wound healing potential of an aqueous extract, poor in antioxidant compounds, has not been examined so far. It was found that the tested extract can enhance cell proliferation of HEK-293 and HaCaT cells significantly. The stages involved in the healing process are hemostasis, inflammation, cellular proliferation, and tissue remodeling. The supernatant was rejected, and the resulting cell pellet was washed with PBS, and centrifuged to the above conditions.

With regard to the reducing power of the extract, the electron donor ability of the compounds contained in the extract is limited compared to that of BHT ( Figure 4D).To address this issue, among others, growth factors, including epidermal growth factor (EGF) and transforming growth factor (TGF), have been examined [ 1]. Sunscreen: If you’re using Madecassol cream during the daytime, follow it up with a broad-spectrum sunscreen with SPF to ensure complete UV protection. Perform a patch test before using Madecassol cream on your face to ensure you don’t have an adverse reaction. Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: A systematic review. Dongkook Pharmaceutical, the current manufacturer of Madecassol products, first imported Madecassol ointment from a French pharmaceutical company, Laroche Navarron.