Sodir, N.M.; Evan, G.I. Finding cancer’s weakest link. Oncotarget 2011, 2, 1307–1313. [ Google Scholar] [ CrossRef][ Green Version] Bumblauskiené, L.; Jakstas, V.; Janulis, V.; Mazdzieriené, R.; Ragazinskiené, O. Preliminary analysis on essential oil composition of Perilla L. cultivated in Lithuania. Acta Pol. Pharm. 2009, 66, 409–413. [ Google Scholar] [ PubMed] Pastushenko, I.; Blanpain, C. EMT Transition States during Tumor Progression and Metastasis. Trends Cell Biol. 2019, 29, 212–226. [ Google Scholar] [ CrossRef][ Green Version] Several animal studies have found that walnuts could help improve brain health as a result of their omega-3 content.

Liu, H.; Wang, F.; Liu, X.; Xie, Y.; Xia, H.; Wang, S.; Sun, G. Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients. Lipids Health Dis. 2022, 21, 20. [ Google Scholar] [ CrossRef] If you choose to start perilla indoors, to give it a head start on the grow season, start the seeds approximately two months prior to transplant. Part of the anti-cancer effect of perilla extract is due to RA through two separate mechanisms: inhibition of the inflammatory response and scavenging of reactive oxygen radicals. The stomach is important for chemical breakdown of food and in delivering its content to the small intestine. Along the journey, changes are high that something can go wrong. This can range from stomach ulceration, to chronic inflammatory disease of the intestine, such as that associated with Crohn’s disease. Perilla seed oil can reduce the severity of discomfort associated with these conditions, helping to reinforce the integrity of these mucosal cell linings. 8. Protects The Kidneys

This can make it challenging for vegans, vegetarians, or even those who simply dislike fish to meet their omega-3 fatty acid needs. Zhang, Y.; Liu, S.; Feng, Q.; Huang, X.; Wang, X.; Peng, Y.; Zhao, Z.; Liu, Z. Perilaldehyde activates AMP-activated protein kinase to suppress the growth of gastric cancer via induction of autophagy. J. Cell. Biochem. 2019, 120, 1716–1725. [ Google Scholar] [ CrossRef] [ PubMed] The best way to get rid of whiteflies is to spray your plant with insecticide or apply neem oil. You can also try placing bug control spikes on the ground around your plant to get rid of them. Jochems, F.; Thijssen, B.; De Conti, G.; Jansen, R.; Pogacar, Z.; Groot, K.; Wang, L.; Schepers, A.; Wang, C.; Jin, H.; et al. The Cancer SENESCopedia: A delineation of cancer cell senescence. Cell Rep. 2021, 36, 109441. [ Google Scholar] [ CrossRef] Perilla oil is very rich in omega-3 fatty acids, with ALA making up an estimated 64% of this seed oil ( 31).

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Lee, Y.H.; Kim, B.; Kim, S.; Kim, M.-S.; Kim, H.; Hwang, S.-R.; Kim, K.; Lee, J.H. Characterization of metabolite profiles from the leaves of green perilla ( Perilla frutescens) by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry and screening for their antioxidant properties. J. Food Drug Anal. 2017, 25, 776–788. [ Google Scholar] [ CrossRef] Ahmed, H.M.; Tavaszi-Sarosi, S. Identification and quantification of essential oil content and composition, total polyphenols and antioxidant capacity of Perilla frutescens (L.) Britt. Food Chem. 2019, 275, 730–738. [ Google Scholar] [ CrossRef] PSO and Ros A scavenge TNF-α induced ROS levels, resulting in reduced expression of MnSOD, FOXO1, NF-κB, and JNK signaling pathways. Li, J.J.; Li, Z.; Gu, L.J.; Choi, K.J.; Kim, D.S.; Kim, H.K.; Sung, C.K. The promotion of hair regrowth by topical application of a Perilla frutescens extract through increased cell viability and antagonism of testosterone and dihydrotestosterone. J. Nat. Med. 2018, 72, 96–105. [ Google Scholar] [ CrossRef] Uemura, T.; Yashiro, T.; Oda, R.; Shioya, N.; Nakajima, T.; Hachisu, M.; Kobayashi, S.; Nishiyama, C.; Arimura, G.I. Intestinal Anti-Inflammatory Activity of Perillaldehyde. J. Agric. Food Chem. 2018, 66, 3443–3448. [ Google Scholar] [ CrossRef]PAH activates AMPK by increasing Thr172 phosphorylation and activity; PAH increases the expression of beclin-1, LC3-II, caspase-3, and p53. Okuno, M.; Tanaka, T.; Komaki, C.; Nagase, S.; Shiratori, Y.; Muto, Y.; Kajiwara, K.; Maki, T.; Moriwaki, H. Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats. Nutr. Cancer 1998, 30, 186–193. [ Google Scholar] [ CrossRef] Kangwan, N.; Pratchayasakul, W.; Kongkaew, A.; Pintha, K.; Chattipakorn, N.; Chattipakorn, S.C. Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and Metabolic Disturbance in Obese-Insulin-Resistant Rats. Nutrients 2021, 13, 3141. [ Google Scholar] [ CrossRef] [ PubMed] Perilla can have a similar effect as other types of mint which is why most pests and diseases leave it alone. However, there are a few issues you could possibly run into when raising perilla. Osakabe, N.; Yasuda, A.; Natsume, M.; Sanbongi, C.; Kato, Y.; Osawa, T.; Yoshikawa, T. Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice. Free Radic. Biol. Med. 2002, 33, 798–806. [ Google Scholar] [ CrossRef]