Mathoulin-Pelissier S, Bellera C, Gregoire F, Yang-Ting L, Malfilatre A. Deployment of a centralized randomization service by internet in the trans European network Alea for clinical trials services (TenAlea) project. Bull Cancer. 2008;95:s73–s4. First bite syndrome doesn’t mean you have any additional health risks. However, it can certainly have a negative impact on your quality of life. Who does first bite syndrome affect? Child anthropometrics are measured at all t’s. Infants’ body weight is measured by asking mothers to first stand on a calibrated electronic personal scale (KERN MPC/SECA robusta 813) themselves, and then again while holding their infant. The difference between these two weights produces the child’s weight. As of t 24, children are invited to stand on the scales themselves. Weight is measured in 0.1 kg. Infants’ length is measured by lying them down on a small mat with an indication of centimeters printed on top of it. As of t 24 child length is measured using a stadiometer (SECA 213, Chino, USA/Garant).

Stoopler ET, Elmuradi S. Idiopathic First Bite Syndrome. Journal of Oral and Maxillofacial Surgery 2016; 74: 872-874.Skinner JD, Carruth BR, Bounds W, Ziegler P, Reidy K. Do food-related experiences in the first 2 years of life predict dietary variety in school-aged children? J Nutr Educ Behav. 2002;34(6):310–5.

For optimum results feed four times daily the amount your fish will consume within 1 minute. Care should be taken to avoid feeding larger quantities of food less often. Coulthard H, Harris G, Fogel A. Exposure to vegetable variety in infants weaned at different ages. Appetite. 2014;78:1–6. Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med. 2002;346(11):802–10.Boak R, Virgo-Milton M, Hoare A, de Silva A, Gibbs L, Gold L, et al. Choosing foods for infants: a qualitative study of the factors that influence mothers. Child Care Health Dev. 2016;42(3):359–69. Research shows that pain relievers, including NSAIDs (nonsteroidal anti-inflammatory drugs), aren’t effective in the treatment of first bite syndrome. Lifestyle changes Bartholomew Eldregde LKB, Markham CM, Ruiter RA, Kok G, Parcel GS. Planning helath promotion programs: an intervention mapping approach. San Francisco: John Wiley & Sons; 2016.

Fildes A, Lopes C, Moreira P, Moschonis G, Oliveira A, Mavrogianni C, et al. An exploratory trial of parental advice for increasing vegetable acceptance in infancy. Br J Nutr. 2015;114:328–36. Baby’s First Bites will be the first trial explicitly testing the separate and combined effects of promoting the what and how of complementary feeding. By comparing three prolonged, intensive interventions, we will be able to draw firm conclusions on what is most important to focus on when promoting vegetable acceptance and children’s self-regulation of energy intake in early childhood; what food to offer, how to offer this food, or a combination of the two. Moreover, this will be the first trial to include an intervention specifically manipulating sensitive feeding practices without manipulating any other variables, evaluating its effects using both self-report and observational measures. This allows conclusions on whether this parenting practice will indeed promote healthier food preferences in children and will foster children’s ability to self-regulate their energy intake, as is often suggested in the literature. At t 12, t 18, t 24, and t 36 vegetable intake is measured by asking mothers to fill out web-based 24-h recalls on three randomly assigned, non-consecutive days using the online program, Compl-eat, developed by Wageningen University and Research. Compl-eat is based on the multiple pass method [ 85] to increase accuracy of dietary recalls and uses the Dutch food composition table [ 86] to calculate energy and nutrient intake. The program was adapted to assess the diets of infants and young children for this study (e.g., inclusion of smaller portion sizes, and special baby foods). The recall days are scheduled in advance. The parent is provided with a paper food diary to be filled out throughout the day if the child is not in the parents care, but for instance with a babysitter or at a day-care center, making it possible for the parent to enter the data in Compl-eat afterwards. In addition, the parent is asked to weigh all vegetables consumed by the child on a digital scale. Instructions on how to fill out Compl-eat are given during the home visits of t 12, t 18, t 24, and t 36; invitations to fill out the recalls are sent after the home visits.Barends C, De Vries JHM, Mojet J, De Graaf C. Effects of starting weaning exclusively with vegetables on vegetable intake at the age of 12 and 23 months. Appetite. 2014;81:193–9.