Abuse and misuse of loperamide, the active ingredient in this medicine, have been reported. Do not take this product for anything other than its intended use (see section ‘What this medicine is for’) and never take more than the recommended amount (see section ‘How to take this medicine’). If you have IBS, which has previously been diagnosed by a doctor, but you notice any of the following new symptoms: The concomitant administration of Loperamide (16mg single dose) and ketoconazole, an inhibitor of CYP3A4 and P-glycoprotein, resulted in a 5-fold increase in Loperamide plasma concentrations. This increase was not associated with increased pharmacodynamic effects as measured by pupillometry. If you are allergic to loperamide or to any of the ingredientsin this medicine (see “What is in this medicine”)

Travellers’ diarrhoea can often be prevented by practising good hygiene and food safety practices, such as washing hands frequently with soap and water, avoiding tap water, ice, and raw or undercooked foods, and choosing bottled water and food that has been cooked thoroughly.IF YOU TAKE TOO MUCH: If you take more capsules than you should, tell your doctor or pharmacist. 4. POSSIBLE SIDE EFFECTS For reasons of hygiene and safety, personal grooming products, cosmetics or items of intimate clothing cannot be returned. headaches – make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe. If you miss a dose of loperamide, do not worry. Just take a dose after you next go to the toilet and have a runny poo. Two capsules (4mg) to be taken initially, followed by 1 capsule (2mg) after ever loose stool (motion), or as previously advised by your doctor. The maximum daily dose should not exceed 6 capsules (12mg).

Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs such as ibuprofen and aspirin can irritate the lining of the stomach and intestines, leading to diarrhoea.Please note that these capsules relieve the symptoms of diarrhoea only and should not be used as a substitute for rehydration treatment. 2. BEFORE YOU TAKE THE MEDICINEDo not take this medicine if: Dehydration may be a complication of diarrhoea, as large amounts of fluid are lost in the stools. This medicine acts only to make the stools more solid and less frequent and does not replace lost fluids. Therefore it is important to drink more fluid than usual. Concomitant treatment with oral desmopressin resulted in a 3-fold increase of desmopressin plasma concentrations, presumably due to slower gastrointestinal motility. This medicine only treats the symptoms of diarrhoea and should not be taken for long periods of time.