If the type III test of the fixed effect of time by randomization was significant, then we used pairwise comparisons to determine the unique differences in effects over time by study arm between baseline and followup at 30 and 60 days for depression, anxiety, and quality of life variables. MTHFR 677CT + MTHFR 1298AC = a compound heterozygous variant which is one variant from two different parts of the gene – this seems to be the worst form of the variant. B-Complex refers to the eight B vitamins including, B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). If you experience any negative effects – severe anxiety, panic, headaches, migraines, insomnia, palpitations, rash and achy joints – please discontinue use of methyl-folate products and seek the help of a trained practitioner who can help you get to the root cause.

Figure 1 shows the mean values for the BDI and BAI over the course of the intervention for both study groups. While this product is not third-party tested by our most trusted organizations, they do in-house testing for heavy metals, solvents, pesticides, and ingredient testing. With Nordic Naturals B-Complex, you'll get a dose of all eight B vitamins, ranging from 83% to 10,417% of your daily needs. In addition, the nutrient bioavailability (the amount your body absorbs) from supplements varies by vitamin or mineral type and form, so higher amounts of certain nutrients may be included assuming your body won't absorb the entire dose. NOTE: If you find that your ‘folic acid’ or your B12 lab test levels are high this could be an indicator that you have a MTHFR gene variant.B vitamins are found in a wide variety of foods in different amounts, including leafy greens, salmon, legumes, eggs, milk, beef, and whole grains. Some people may even have genetic differences, polymorphisms that reduce their ability to methylate quite significantly. However, there are RDAs and ULs established for the individual B vitamins themselves, which can be found in the Dietary Supplement Fact Sheets provided by the National Institutes of Health. Supplementation may help prevent or correct related issues, including issues with red blood cell formation and psychiatric symptoms.

Vegans and vegetarians: Vegans should supplement with 250 micrograms of vitamin B12 per day, and vegetarians who eat eggs and dairy should supplement with this amount every few days.

This prenatal vitamin does not contain iron or omega-3s, which you may want to consider taking separately, depending on your diet and nutritional status.