Yeah. And what’s great about the formula is that it’s the levels shown in the clinical trial, which we’ll have the links to those below, that is the same level that’s placed inside the formula. Now we’re not just here to talk about the new formula that you put together, Gut Food. You’ve been using probiotics as part of your protocols that you’ve written in your book for a really long time. And one of the great things is that there’s a lot of really great companies, a lot of we call them the Doctors’ Brands. Metagenics, Designs for Health, Thorn, Clair Labs. I’m leaving out a few. Pure Encapsulations. They have been some of the most incredible brands and many others in that ecosystem that have really touted the benefits and educated many practitioners like yourself about how different strains of probiotics could be used to deal with patients who are struggling with various sorts of things.

Based on the data provided, there are no nutritional safety concerns with the food use of LactoSpore®. 7.Toxicological AssessmentWhat makes LactoSpore® extra special is that it can resist warmer temperatures. This means you can store them at room temperature, and drink a warm drink soon after taking them (which isn’t the case with most probiotics).

Is so key. So Mark, when it comes to shopping for probiotics, what are some of the things that people can be looking for when choosing the right probiotic? The beautiful thing about our understanding about the relationship between the microbiome and our belly fat and our metabolism is that it’s mediated through changes in the microbiome that drive inflammation. We talked about it earlier, the metabolic endotoxemia, the basic toxins in your gut that leak across and start to trigger immune responses. And the immune responses then generate a cascade of responses that increases certain cytokines like interleukin six. So if you have a bad gut, if you have a leaky gut, if you’re eating the wrong foods, you’re going to get high interleukin six, which is going to create more insulin resistance, create more weight gain, create more belly fat, and a vicious cycle. Estimated daily intake (EDI) of 36.4 x 10 9 CFU based on the consumption of 18.2 servings of food per day from USDA data (as reported in GRAS GRN 601) was provided. This EDI is very conservative as it assumes that nearly all food products consumed will contain LactoSpore®, and it is a reasonable approximation to Canadian daily serving intakes based on the available Canadian Community Health Survey data. 4.Chemical Assessment

No, absolutely. There’s ton of great companies that are doing stuff in the space. And I think through education and digging in a little bit and asking the companies how they approach it, that’s a big part of the process. Talk a little bit more about LactoSpore, which is the probiotic that you put in your formula.

So while fermented foods are good, they’re good in the right person, because if your gut’s not sorted, and I call it the weeding, seeding, and feeding program, if you haven’t done the weeding and you got a lot of bad bugs in there, you start eating fermented foods, you’re going to have a problem. So if you have yeast overgrowth, if you have small intestinal bacterial overgrowth, if you have histamine intolerance, you should be very careful. So if you don’t react well to fermented foods, it doesn’t mean fermented foods are bad for you. It means there’s something wrong with your gut, find it and fix it. An in vitro study provided suggested that B. coagulans strain MTCC 5856 may survive the upper gastrointestinal tract. It produces lactic acid, a metabolite that has been shown to support gut health by lowering the luminal pH and inhibiting the growth of bacterial pathogens. B. coagulans MTCC 5856 fermentation of fibre in vitro also results in the production of short-chain fatty acids (SCFAs) such as acetic, propionic and butyric acid that play a role in gut health through various mechanisms including providing an energy source for colonocytes. As with any dietary supplement, it is always advisable to consult with a healthcare professional before making changes to your routine. With proper guidance and commitment to your gut health, Lactospore can play a vital role in optimizing your digestive wellness and enhancing your overall quality of life. A balanced gut microbiome plays a crucial role in maintaining a robust immune system. Lactospore's ability to promote a healthy gut environment indirectly boosts the immune system, helping to ward off infections and maintain overall health (5). 2. Mental Health and Cognitive FunctionThe effect of Bacillus coagulansMTCC 5856 (LactoSpore ®) on castor oil induced diarrhoea and gastrointestinal (GI) motility using well established in vivo studies found LactoSpore ® exerted dose dependent anti- diarrhea activity and reduced the faecal output (33%). It also inhibited the gastrointestinal motility. The results suggested thatLactoSpore ® possess significant anti-diarrheal activity and therefore could be a potential agent in the management of diarrhea. LactoSpore® is unique in that it maintains functionality throughout manufacturing, preparation and storage, and is prepared to survive your stomach acids and digestive enzymes once in your body. As a result, you get a convenient probiotic supplement that’s stable at room temperature, doesn’t require refrigeration, and provides 600 million spores in a single, convenient tablet. The Purpose Dutta P, Mitra U, Dutta S, et al. Randomised controlled clinical trial of Lactobacillus sporogenes (Bacillus coagulans), used as a probiotic in clinical practice, on acute watery diarrhea in children. Trop Med Int Health 2011;16(5):555-61. View abstract. Several human studies suggested that probiotic strains have shown to improve the clinical symptoms such as cognitive performance beneficial effects on anxiety, depression and emotional arousal ( 13, 15, 40, 41). Moreover, these studies were conducted in healthy subjects and its clinical relevance to disease remains unclear. This is the first study to report the clinical safety and efficacy of B. coagulans MTCC 5856 for the management of MDD in IBS patients. However, a recent placebo-controlled trial concluded that the probiotic Bifidobacterium longum NCC3001 reduces depression but not anxiety scores and increases quality of life in patients with IBS ( 42). This study provides the additional evidence that probiotics may ameliorate the symptoms of depression in patients with IBS. Vaclav V, Jana V. Physiological effects of a combination of cinnulin with probiotics. Am J Immunol. 2013;9:10

Kimmel, M., Keller, D., Farmer, S., & Warrino, D. E. (2010). A controlled clinical trial to evaluate the effect of GanedenBC30 on immunological markers. Methods and Findings in Experimental and Clinical Pharmacology, 32(2), 129-132. Once Lactospore reaches the intestines, it germinates and produces lactic acid, which lowers the pH of the intestinal environment. This inhibitory action prevents the growth of harmful bacteria, such as Escherichia coli, Salmonella, and Clostridium, promoting a balanced gut microbiome and reducing the risk of gastrointestinal infections (2). B. Enhancement of Gut Barrier Function That’s amazing just from a probiotic, right? So there are a lot of ones on the market out there. This one’s shelf stable, so you don’t have to refrigerate it, which is a big deal to be able to travel with it. And two, it’s one that is a very unique form called Bacillus coagulans that has all these benefits. Not all probiotics are the same and not all have these benefits, but this one is really well studied and actually has these incredible benefits.

Gupta RS, Patel S, Saini N, Chen S. Robust demarcation of 17 distinct Bacillus species clades, proposed as novel Bacillaceae genera, by phylogenomics and comparative genomic analyses: description of Robertmurraya kyonggiensis sp. nov. and proposal for an emended genus Bacillus limiting it only to the members of the Subtilis and Cereus clades of species. Int J Syst Evol Microbiol. 2020;70(11):5753-5798. View abstract. Test results were provided for the presence of microbial contaminants in the final spore preparation, specifically Staphylococcus aureus, Salmonella spp., Pseudomonas aeruginosa, coliforms, Escherichia coli, enterobacteriaceae, yeast and mold. All testing was conducted according to USP or FDA-BAM methods. Certificates of analysis for nine production lots demonstrated compliance with these specifications. No safety concerns were found regarding the food use of LactoSpore® from a microbiological perspective. 6.Nutritional Assessment Yeah. So I mean without them, they tastes pretty bad. Without sugar, it tastes pretty bad. So I’m kind of not a huge fan. I think for the right person, it can be fine. And if your gut’s pretty healthy, it can be fine. But if you are struggling with weight, if you have blood sugar issues or a lot of overgrowth or yeast problems, it can be problematic. Taxonomically, this bacterial strain belongs to the species B. coagulans classified as a Risk Group 1 microorganism by the Public Health Agency of Canada. Risk Group 1 microorganisms are not associated with human disease. Therefore, B. coagulans as a species is considered a non-pathogenic microorganism.