A glucose disposal agent is a nutritional supplement that helps reduce blood sugar levels. It does not contain insulin and can be used by people with Type 2 diabetes who do not produce enough insulin or cannot use the insulin they produce effectively. Glucose disposal agents do not replace diet and exercise in managing your diabetes, but they may help you achieve better results when combined with good self-management practices. The Ingredients Necessary For A (Good) Glucose Disposal Agent and Their Synergistic Effect On Insulin Sensitivity Please do not misinterpret this information. This does not mean that putting cinnamon on your post-workout oatmeal will reduce muscle growth – you would probably need a ridiculously large amount over long periods of time. However, it could mean that taking concentrated cinnamon extract pills post-workout might not be the best of ideas. Chromium As described above, AMPK is an inhibitor of mTOR, which is the master regulator of protein synthesis. The authors measured the phosphorylation (activation) of basal AMPK in the metformin group compared to placebo. Specifically, they measured the ratio of phosphorylated-AMPK:total-AMPK, which was 21.3% in the metformin group and 1.6% in placebo. However, the between-group differences did not reach significance. A downstream target of AMPK (Phospho-ACC) was found to be significantly higher in the metformin group compared to the placebo group (42.2% vs. 6.2%, p=0.035).

Important: Do not take this as medical advice. It is not intended to replace anything said by your physician. If you have been prescribed metformin, speak to your physician and follow what they say. LipoSan Ultra® Chitosan - Chitosan attaches to fats and oils and helps your body eliminate the fats and oils as waste before your body can absorb the fat. LIPOSAN ULTRA product features patented technology that increases the density of regular chitosan and makes it work faster than regular chitosan to remove fats and oils from your system. Maddux, B., See, W., Lawrence, J., Goldfine, A., Goldfine, I., & Evans, J. (2001). Protection against oxidative stress-induced insulin resistance in rat l6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes, 50(2), 404-10.In healthy people: blood glucose levels are tightly regulated by functional pancreatic beta-cells that are able to secrete adequate amounts of insulin when needed. When blood glucose goes up, insulin is secreted and glucose is shuttled to adequate tissues – this process does not need external aid in healthy individuals. In people with diabetes, on the other hand, external aid (drugs, supplements, etc.) are needed to shuttle the blood glucose to tissues since insulin is not being secreted to do its job. Shuttling Glucose Into Muscle Our formula can be used for pre and post-workout for nutrient shuttling. This can lead to turning your carbs into enhancing muscle

Cinnamomum cassia (also known as Chinese cinnamon) is cultivated widely in Southeast asia and has been used for centuries in Traditional Chinese Medicine to treat diabetes, chronic inflammation, and immune deficiency [ 7]. The bark of cinnamon is a rich source of medicinal compounds, notably cinnamaldehyde and eugenol. These antioxidants have ubiquitous actions throughout the body but are especially beneficial for supporting healthy blood glucose levels after consuming a carbohydrate-rich meal [ 8]. Coughlan, K. A., Valentine, R. J., Ruderman, N. B., & Saha, A. K. (2014). AMPK activation: a therapeutic target for type 2 diabetes?. Diabetes, metabolic syndrome and obesity : targets and therapy, 7, 241-53. doi:10.2147/DMSO.S43731 Alpha Lipoic Acid did not show benefits after 4 years of supplementation in 460 diabetics. Its proposed to aid through antioxidant effects, however, a high-quality diet can provide the necessary antioxidant effects.Banaba Leaf Extract - Banaba (known as the “Pride of India”) is commonly included in GDAs because it is touted as an insulin agonist, which means that it has the ability to bind to insulin receptors and exert actions in the body similar to those exerted by the real hormone. Perhaps the most common ingredient in GDAs, berberine is a chemical that is extracted from natural sources such as barberry, goldenseal, goldthread, Oregon grape, Phellodendron, and tree turmeric. Berberine is put into GDA products since it has been found to have beneficial effects on glucose metabolism for diabetics but this does not translate to healthy individuals with normal glucose metabolism. Further, much of the literature has been done on mice and cannot be directly applied to humans. Let’s review the literature on berberine, just so you will see what I mean.

A review by Havel ( 27) investigated the role of chromium in insulin resistance and noted that various studies have demonstrated chromium’s ability to enhance the metabolic action of insulin and lower some of the risk factors for cardiovascular disease, particularly in overweight individuals. The author also noted that chromium picolinate, specifically, has been shown to reduce insulin resistance, improve blood glucose control, and to help reduce the risk of cardiovascular disease and type 2 diabetes. I also have them take another 4 capsules of SLIN when they wake up in the middle of the night to use the rest room. This accomplishes two things:Zhao, P., Wang, J., Ma, H., Xiao, Y., He, L., Tong, C., . . . Li, J. (2009). A newly synthetic chromium complex—chromium ( d-phenylalanine) 3 activates amp-activated protein kinase and stimulates glucose transport. Biochemical Pharmacology, 77(6), 1002-1010

The key ingredients of Time 4 GDA have been shown scientifically to provide a number of benefits for health and performance. Cinnamon Bark Extract - works as a glucose disposal agent (GDA) by slowing down the rate at which glucose actually enters our bodies. This means that you have a two-fold effect of lowering spikes in blood sugar as well as improving glucose utilization within the cell itself.Glucose disposal agents (GDAs) are substances that aid the uptake of glucose from the blood stream into the muscle tissue where it can be used immediately to fuel activity, or can be stored in the muscles and liver as Glycogen to provide energy when needed later. Glucose Disposal Agents (GDAs) increase muscle cells sensitivity to Insulin therefore reducing the need for high levels in the blood and helping to ensure that the carbohydrate we consume is used as fuel for activity, rather than stored as body fat, and so potentially enhancing performance, recovery, and body composition. Cinnamon: The research on glucose tolerance is inconclusive. At best, it may be beneficial in people with Type 2 Diabetes. If it does have an effect, it’s likely that its through AMPK activation, which would have inhibitory effects on muscle protein synthesis. Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81