moscatilin) has been patented as an agent inhibiting cervical cancer cell proliferation and inducing autophagic apoptosis in vitro in an effective concentration in the range of 25-200 mol/L (patent CN105943523). Among other diabetic complications, diabetes-induced cardiomyopathy (DCM) mediated by hyperglycemia can induce the adverse architectural remodeling of heart, and ultimately lead to heart failure and death. The ones, which are often explored, are cancer, neurodegenerative diseases and diabetes mellitus as they are widely associated to elderly. huoshanense reduced the levels of some cytokines associated with atopic dermatitis and had beneficial effects on symptoms.

cytotoxic, anti-proliferative, anti-metastatic, antitumor, anti-genotoxic, antimigratory or apoptotic properties in vitro or in vivo and suggest their potential anticancer effects. A253 cells were pre-treated with DP for 12hr before TNF-α addition, then NF-κB, phosphorylation of MAPKs, ROS generation, mitochondrial membrane potential and proapoptotic proteins were examined. Chrysotobibenzyl, crepidatin, chrysotoxine, moscatilin and nobilin B, isolated from Dendrobium species, were evaluated for their protective effects against 6-hydroxydopamine (6-OHDA)-induced toxicity in the human neuroblastoma cell line SH-SY5Y. This indicated that Dendrobium mixtures could improve autoimmune activity in diabetic rats, thereby enhancing the ability of the body to counter external pathogens and stimuli.The difference between these two hypoglycemic activities of DCP might result from different lavaging dosages, treatment time and extraction procedure of DCP.

huoshanense polysaccharide molecular weight decrease, using pectinase hydrolysis, improved its inhibitory action on nonenzymatic glycation of proteins. org), Dendrobium is the second largest orchid genus after Bulbophyllum, widely distributed throughout Asia, Europe and Australia. w. DOP-W3-b time- and dose-dependently stimulated the proliferation of bone marrow cells by the oral administration of 0.The prescriptions are mostly preventive or assisting diabetes treatments, reducing blood glucose, improving yin-deficiency, and accompanying patients with chemotherapy or radiotherapy. Moreover, aging can be examined from an immunological point of view, because it is generally accepted, that the immune system does not work as well as we grow older and becomes altered with age.

The majority of reported studies deal with in vitro evaluations of potential anticancer effects of crude Dendrobium extracts or isolated compounds. However, after 48hr, moscatilin became the most potent compound, as a result of the substantial increase of its activity during the period of 24-48hr.

investigated protective effects of DNLA on Aβ peptide segment 25-35 (Aβ 25-35)-induced neuron and synaptic loss in mice [ 61]. The Chinese consider Dendrobium as one of the fifty fundamental herbs used to treat all kinds of ailments and use Dendrobium tonic for longevity. The overall results proved that Dendronan ® significantly promoted the splenocyte proliferation (at 80 mg/kg BW), corrected the imbalance in spleen lymphocytes subsets ratio (CD3 ratio at 40 mg/kg BW), reversed the diminution of cytokine levels (TNF-α secretion at 80 mg/kg BW), and stimulated the formation of Ig and heamolysin (40 mg/kg BW) [ 100]. w. on diabetic mice for 7 days, while DCP was orally administered at the concentration of 50-200 mg/kg b. Polysaccharides are the main effective ingredients of Dendrobium species with the strongest immunomodulatory activities ( Table 4).