CoQ10 may reduce the effectiveness of warfarin (Jantoven), as well as interact with some blood pressure and cancer medications. In terms of achieving the systemic effects of CoQ10 supplementation, the shortest time period reported in the scientific literature is about two weeks, from research on exercise performance ( 11 ). Other research has used substantially longer interventions, up to six months in length or longer (some studies last several years). Shidal C, et al. (2019). Prospective study of plasma levels of coenzyme Q10 and lung cancer risk in a low-income population in the Southeastern United States.

Synergistic blend of powerful antioxidants to improve cholesterol levels and help boost the immune system Taking statins may reduce the amount of CoQ10 in a person’s blood. Studies have shown a significant reduction in plasma CoQ10 concentrations following treatment with statins. Coenzyme Q10 (CoQ10) is a naturally occurring chemical that carries out several vital roles, including promoting energy production and neutralizing harmful particles called free radicals. CoQ10 is naturally found in the body, with the highest levels in the heart, liver, kidney, and pancreas. It helps generate energy in cells by making the antioxidant adenosine triphosphate (ATP), which is involved in cell energy transfer, and serves as an antioxidant to protect cells against oxidative stress. CoQ10 plays a vital role in energy production and DNA replication and repair. It also acts as an antioxidant, neutralizing harmful free radicals.Additionally, some products offer a solubilized form of CoQ10, or a combination of CoQ10 and oils, to improve its absorption. Summary

Moreover, supplementing with CoQ10 may help reduce fatigue, which could also potentially improve exercise performance. Summary CoQ10 could also assist with restoring optimal levels of energy production, reducing oxidative damage, and improving heart function, all of which can aid the treatment of heart failure. Summary Standard daily doses of CoQ10 range from 60 milligrams (mg) to 500 mg. The highest recommended dose is 1,200 mg. However, clinical trials have used dosages as high as 3,000 mg per day. Coenzyme Q10 (CoQ10) is an antioxidant that your body produces naturally. Your cells use CoQ10 for growth and maintenance.Likewise, other research found that CoQ10 supplementation could boost ovary function and extend the longevity of high-quality eggs in women ( 10 ). CoQ10 supplements appear to be safe, and most people tolerate them even at high doses. However, CoQ10 supplements can cause the following side effects: Another study in people with diabetic neuropathy — a type of nerve damage that can occur in people with diabetes — found that taking 100 mg of CoQ10 daily for 12 weeks may have improved HbA1c levels and insulin resistance.

People can obtain CoQ10 by eating certain meats and grain proteins, but the quantity present in these foods is too small to increase CoQ10 levels in the body significantly. Mantle D & Dybring A. (2020). Bioavailability of Coenzyme Q 10: An overview of the absorption process and subsequent metabolism. In particular, research suggests that it may help improve heart health and blood sugar regulation, protect against certain types of cancer, and reduce the frequency of migraine.Many CoQ10 supplements contain 100 or 200 mg per serving, but for those who need a higher dose, we recommend Kirkland Signature’s 300 mg option. Sure, you could just take three servings of a 100 mg option to reach this dosage, but from a cost and convenience standpoint, this 300 mg option is worth it. There’s only one softgel per serving, so you won’t need to up your pill count to reach 300 mg of CoQ10. Plus, we appreciate they’re third-party tested by USP. Zeng, Z. Y., et al. (2018). Efficacy of CoQ10 as supplementation for migraine: A meta‐analysis [Abstract]. CoQ10 is an essential nutrient present in almost every cell of the human body. The following foods also contain CoQ10: Johansson, P., et al. (2015). Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. Results from a double blind, placebo-controlled prospective study [Abstract].

Florou P, Anagnostis P, Theocharis P, Chourdakis M, Goulis DG. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials. J Assist Reprod Genet. 2020;37(10):2377-2387. doi:10.1007/s10815-020-01906-3 Liang Y, Zhao D, Ji Q, et al. Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. EClinicalMedicine. 2022;52:101602. doi:10.1016/j.eclinm.2022.101602The bulk of scientific research studies use doses of 150 to 200 milligrams of coenzyme Q10, suggesting that the optimal dose for both cognitive and physical function lies within this range. This perspective motivated Transparent Labs to master a formula that delivers pure CoQ10 without fillers or allergens, consistently prepared across batches in their state-of-the-art facility. Qu H, Guo M, Chai H, et al. Effects of coenzyme q10 on statin‐induced myopathy: an updated meta‐analysis of randomized controlled trials. J Am Heart Assoc. 2018;7(19):e009835. doi:10.1161/JAHA.118.009835 Alahmar AT. The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med. 2019 Sep;46(3):112-118. doi:10.5653/cerm.2019.00136