Dolz-Marco R, Litts KM, Tan ACS, Freund KB, Curcio CA. The evolution of outer retinal tubulation, a neurodegeneration and gliosis prominent in macular diseases. Ophthalmology. 2017; 124(9):1353-1367 We know Toad of Toad Hall loved driving, but in real life, toads and cars don't always get along. Toads are slow to cross roads, so these signs warn you to approach carefully to help protect vulnerable species.

The earliest known use of the symbols < and > is found in Artis Analyticae Praxis ad Aequationes Algebraicas Resolvendas ( The Analytical Arts Applied to Solving Algebraic Equations) by Thomas Harriot, published posthumously in 1631. [1] The text states " Signum majoritatis ut a>b significet a majorem quam b (The sign of majority a > b indicates that a is greater than b)" and " Signum minoritatis ut a < b significet a minorem quam b (The sign of minority a < b indicates that a is less than b)."Pilotto E, Benetti E, Convento E, Guidolin F, Longhin E, Parrozzani R, et al. Microperimetry, fundus autofluorescence, and retinal layer changes in progressing geographic atrophy. Canadian Journal of Ophthalmology. 2013; 48(5):386-393

Treatment involves physical therapy to help restore range of motion; over-the-counter, nonsteroidal anti-inflammatory drugs to ease pain; and sometimes cortisone injections to the shoulder joint. Surgery may be needed in some cases. Liu G-H, Lin B, Sun X-Q, He Z-F, Li J-R, Zhou R, et al. Focal choroidal excavation: A preliminary interpretation based on clinic and review. International Journal of Ophthalmology. 2015; 8(3):513-521

You can report a road spillage (e.g. dropped cargo, oil, mud, or sand) to the local council authority or Highways England. Vujosevic S, Bini S, Midena G, Berton M, Pilotto E, Midena E. Hyperreflective intraretinal spots in diabetics without and with nonproliferative diabetic retinopathy: An in vivo study using spectral domain OCT. Journal Diabetes Research. 2013; 2013:1-5 Many conditions can have pain in both shoulders as a symptom. The following details may help you better understand your symptoms and if and when you need to see a physician. Most common causes ER is an important prognostic biomarker in breast cancer. ER-positive tumours have a better prognosis than ER-negative tumours. Overall survival, disease free survival, recurrence/relapse-free survival, 5-year survival, time to treatment failure and time to recurrence have all been shown to be positively associated with ER expression. 4

Matsumoto H, Kishi S, Sato T, Mukai R. Fundus autofluorescence of elongated photoreceptor outer segments in central serous chorioretinopathy. American Journal of Ophthalmology. 2011; 151(4):617-623.e1 x = math.random ( 1 , 9 ) y = 5 if x >= y then print ( "x(" .. x .. ") is more or equal to y(" .. y .. ")" ) else print ( "x(" .. x .. ") is less than y(" .. y .. ")" ) end Bolz M, Schmidt-Erfurth U, Deak G, Mylonas G, Kriechbaum K, Scholda C. Optical coherence tomographic hyperreflective foci. Ophthalmology. 2009; 116(5):914-920 ERα is considered one of the most powerful predictive biomarkers in both primary and advanced breast cancer management, because of the substantial benefit that endocrine therapy provides for ER-positive tumours. ER expression allows for the selection of patients for endocrine therapy with selective oestrogen receptor modulators (SERMs) ( tamoxifen and toremifene) or aromatase inhibitors (AI) (non-steroidal: letrozole and anastrozole, steroidal: exemestane). The European Society for Medical Oncology (ESMO) clinical practice guidelines recommend tamoxifen as the standard endocrine therapy for pre-menopausal patients and AI and tamoxifen are both considered valid options for post-menopausal patients. 6 Summary of Operators". Oracle Corporation. Archived from the original on 16 April 2020 . Retrieved 5 February 2020.Ogino K, Murakami T, Tsujikawa A, Miyamoto K, Sakamoto A, Ota M, et al. Characteristics of optical coherence tomographic hyperreflective foci in retinal vein occlusion. Retina. 2012; 32(1):77-85 The GP may prescribe medicine for your ear infection, depending on what's caused it. Infections inside the ear Tissue handling: time from tissue acquisition to fixation should be standardised and as short as possible. Storage of slides for more than 6 weeks before analysis is not recommended. Duration of tissue fixation: breast tissue specimens must be fixed in 10% neutral buffered formalin for no less than 6 hours and for not more than 72 hours before processing. Shoulder arthritis cannot be cured, but symptoms can be managed to improve quality of life and ease pain and discomfort.

Internal quality control and validation: a comprehensive quality control programme for ER IHC analyses should include all aspects of the test to help ensure an appropriate and expected number of ER-positive breast cancers in the patient population served by the laboratory.There is no standard test for fibromyalgia. The diagnosis is usually made when the above symptoms go on for three months or more with no apparent cause. CDF is a rare form of macular pathology that can be precisely diagnosed only with OCT.It is characterized by large cystic spaces, or in some cases, giant single cyst in the fovea. It can occur with or without thinned septa between cystic spaces. Usually, it affects patients with diabetic maculopathy, uveitis, RVO, AMD, associated with Streptococcus constellatus endocarditis, and CSR [ 3, 86]. The hyperreflective OCT appearance of these lesions, followed by cystic change and permanent visual loss, suggests that they might represent retinal infarctions. Their predilection for the fovea may reflect the high metabolic demand at this area of the retina and the narrow-bore capillaries of the perifoveal vasculature.