It should be noted that taking CoQ10 close to bedtime may cause insomnia in some people, so it’s best to take it in the morning or afternoon ( 41). Shoeibi A, et al. (2016). Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Supplementation therapy has been widely employed in the context of infertility as a mean to improve the success rate in achieving pregnancy both spontaneously and by means of ART. In this context, the evidence strongly suggests that oxidative stress plays a central role in idiopathic infertility [ 15, 16, 17], thus raising interest towards antioxidant therapy in this field. Derosa, G., et al. (2019). Coenzyme Q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: A double-blind, randomized, placebo-controlled study.

Giannubilo S, Orlando P, Silvestri S, et al. CoQ10 supplementation in patients undergoing IVF-ET: the relationship with follicular fluid content and oocyte maturity. Antioxidants. 2018;7(10):141. doi:10.3390/antiox7100141 Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011;3(3):466-467. doi:10.4103/0975-7406.84471However, the authors of a 2015 meta-analysis evaluated the efficacy of CoQ10 supplementation for treating statin-related muscle pain. The meta-analysis included six studies with a combined total of 302 patients. The authors found no evidence that CoQ10 significantly improves statin-related muscle pain. The heart contains some of the highest concentrations of CoQ10 in the body. The vast majority of people with heart disease also have low CoQ10 levels. Researchers now consider low CoQ10 levels to be an indicator of the severity and long term outcome of various heart diseases. El-Leithy ES, et al. (2018). Optimization of nutraceutical coenzyme Q10 nanoemulsion with improved skin permeability and anti-wrinkle efficiency. Our study was limited by the small number of control group participants due to consent, and we did not assess dietary CoQ10 intake, although a dietary assessment could be limited by the complexity of dietary intake and recall bias. We did not assess the pregnancy rate because the follow-up was limited by time and cost constraints. Another limitation is the selection of participants from a single area, so our findings may not be generalizable to all regions, and further large and multicenter studies are warranted. The third-party certifications we can trust are ConsumerLab.com, NSF, and USP. However, these certifications are difficult to obtain and/or expensive for manufacturers, so many companies choose not to get their products tested by one of these three organizations.

Research suggests that mitochondrial dysfunction can contribute to age-related neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. These diseases are associated with free radical damage. Zeng, Z. Y., et al. (2018). Efficacy of CoQ10 as supplementation for migraine: A meta‐analysis [Abstract]. When used alone or in combination with other nutrients, such as magnesium and riboflavin, CoQ10 has been shown to improve migraine symptoms. In a subsequent study, Alahmar et al. administered a 3-month course of 200 mg CoQ10 to 65 patients affected by idiopathic OA related infertility and 40 fertile subjects. The results showed an improvement in semen parameters and a reduction in OS markers and SDF in the former group [ 53]. Suzuki Y, Nagato S, Sakuraba K, Morio K, Sawaki K. Short-term ubiquinol-10 supplementation alleviates tissue damage in muscle and fatigue caused by strenuous exercise in male distance runners. Int J Vitam Nutr Res. 2021;91(3-4):261-270. doi:10.1024/0300-9831/a000627Oxidative damage is one of the main causes of both male and female infertility by negatively affecting sperm and egg quality ( 29, 30). Oxidative stress can interfere with regular cell functioning and may contribute to many health conditions. Therefore, it is not surprising that some chronic diseases have also been associated with low levels of CoQ10.

Though still controversial, some preliminary evidence suggests that CoQ10 may help prevent or treat the adverse effects, such as muscle pains and liver problems, of taking statin-type cholesterol drugs. Sometimes products tested by these three companies are more expensive to try to offset the cost they pay for certification. It is a health supplement that helps to boost heart health and has the essential nutrients that work as a shield to protect your body from free radical damage Though your body makes CoQ10, several factors can deplete its levels. For example, the rate of its production significantly declines with age, which is associated with the onset of age-related conditions like heart disease and cognitive decline ( 5).

Conclusions

A subsequent study with 20 patients with idiopathic asthenozoospermia evaluated the antioxidant capacity of a combination of CoQ10 (200 mg) and aspartic acid (2660 mg). After a 3-month treatment period, there was a significant improvement in sperm kinetics, but not in sperm count or in the number of atypical sperm cells. Levels of nitric oxide and peroxynitrite in seminal plasma decreased, whereas SOD activity increased. Moreover, the percentage of damaged DNA (assessed by comet assay) decreased significantly [ 40].