Should one refrain from taking TTFD supplements in the evening. Are they known to interfere with sleep?

Dias D.A., Urban S., Roessner U. A historical overview of natural products in drug discovery. Metabolites. 2012;2:303–336. doi: 10.3390/metabo2020303. I researched online and believe God led me to several medical articles stating that Thiamine deficiency during the refeeding phase could cause renal tubular dysfunction resulting in electrolyte losses via the kidneys. So electrolyte values during the refeeding phase after fasting could be Refeeding Syndrome’s intracellular losses -OR- urinary losses from Thiamine Deficiency. Re Lipothiamine, would that still work at that dose and once daily considering the alcohol history? Additionally, I did read that there were some safety concerns or adverse effect possibilities for certain people taking it, especially if your GSH is low. Well, I later learned that it’s carbs that trigger me too, 2 years in. Since quitting carbs, I’ve regained an incredible amount of feeling in my body, though this leaves my food choices quite limited.Dr. Lonsdale–THANK YOU to you and Dr. Marrs, from all of us who have been searching for answers for months and years. What I really wonder is, what your current regimen is regarding supplements/vitamins, but it is up to you, if you wish to answer this or not. Neither physician is sure. In the case of my friend, he went from a strong suspicion to feeling it’s just a possibility after thinking it through. He didn’t examine me, it was a phone conversation. He now feels that it may just be b1 deficiency considering the alcohol use was roughly less than a year and I had stopped for 3 months before and was asymptomatic those 3 months , and just presented symptoms after 2 weeks of returning to moderate consumption.

If you are interested, here is a link to Isabella Wendtz’s blog where she talks about Thiamine and thyroid fatigue, and how she supplemented to help herself with it. https://thyroidpharmacist.com/articles/thiamine-and-thyroid-fatigue/ Many thanks for your speedy reply – it’s very much appreciated! We have corresponded before regarding Lupron and the truly appalling effects it has on the body. My mother’s cancer doctor mentioned that it sounded like I had a major b12 deficiency and that I should try supplements. I did and it worked for a time, giving me improvements, but there was still residual numbness. Which gradually got worse. I had a RBC mg test run at the same time and that showed a slight mg deficiency (1.92 with a ref range of 2.08 – 3.00 mmol/l). Again I struggle to supplement with mg as I can’t take it orally. I rely on epsom salt baths and in the past mg oil on my skin.

Palpitations, random bouts of fatigue, frequent urination(pale), tinnitus that randomly spikes worse than ever, horrible memory issues, anxiety and feeling of getting a seizure sometimes after a heavy meal, bad concentraion, anxiety, bad mood, , low motivatio, exercise intolerance, trouble keeping up my weight. I am about 180 cm, and keep losing weight till I reach about 59, and than it stalls. Currently consuming 100mg Lipothiamine. I do not yet see improvement with neuropathy, musculoskeletal pain, insomnia or anxiety with this, but I only added the Thiamine on June 18. As our son grew we worked to reduce the sugar in his diet, but were not sugar free. From 2012 to 2014 he was on this regimen of sugary drinks and foods, recommended by a scientist and the dysautonomia symptoms ramped up from that, I think. When I first came across all this info on thiamine I started supplementing and the worst of my mental confusion, nausea, loss of appetite went away within a few days. I stopped the B1 because of gut pain and the symptoms increased again, I then restarted the B1 and they decreased again. (Unfortunately I had been supplementing for a bit before performing the test but intermittently) I am now using the Authia cream since I struggle with oral supplementation. I have noticed that I feel really tired after applying the cream for most of the day. I seem to remember reading that this would also suggest deficiency as otherwise supplementing would have no effect.

My question today is about our 7-YEAR-OLD SON. He was given Cefdinir in April 2018 for a sinus infection and has had daily, near-constant stomach pain ever since. He also began to exhibit nervousness and fears we previously never saw–asking questions like what if we (his parents) died, being afraid to be away from us in the house, etc. These are more than the usual child-becomes-aware-of-the-world fears and were sudden, coinciding with the Cefdinir. He’s also regularly cold, despite his skin feeling warm. In the past few weeks, he’s becoming more and more irritable. We’ve been to the usual cast of otherwise wonderful, well-meaning providers–pediatrician, pediatric gastroenterologist, etc. He was prescribed Miralax and VSL. We discontinued the Miralax on 12/23/19 (after about 16 months of use) and switched to magnesium citrate gummies, and after VSL recently was discontinued, have switched to Visbiome. I used to eat a diet heavy in sugars and carbs and then noticed numbness forming in my fingers and toes. It took months to learn that it flares up whenever I consume any amount of sugar and even when I eat salt. I don’t drink alcohol at all. I was low carb for several years but in an effort to put on weight and stimulate my metabolism I started increasing carbs. Mostly potatoes since I cant eat grains at the moment and sugar. For a few weeks I was probably eating 60 – 80g sugar per day (previously none except occasional honey). Thank you for your reply and advice. This particular doctor is a top Nephrologist here in NY and he’s also been a close friend since I was in my teens so there were a few advantages talking to him on the subject. In terms of alcohol consumption, about a year ago, for the first time in my life, I start chronic drinking. I stopped for 3 months after the Papilledema diagnosis, but then about 3.5 weeks ago started again, this time consuming much less alcohol. Around 2 weeks ago is when I noticed the memory and balance issue. I have stopped drinking again. I’v not been taking Lipothiamine for a little over a month. I believe the main symptoms of “paradox” have resolved which were emotional volatility, extra physical anxiety and chest pains. I have now increased the dosage to 200mg lipothiamine per day split in the following manner: 100mg at breakfast, 50mg at lunch, 50mg at dinner.Should I still take your recommended dose of 100-200mg Lipothiamine in addition to Magnesium Taurate or would the dose now be different? You previously advised to raise the dose “gradually” until symptoms yield. Do you ahve a general schedule to increase? For example, I waited at 150mg for a week, then I raised to 200mg. The patients in the articles were repleted after a short period of days to weeks and had resolution of their electrolyte imbalances. I am concerned though because I have been in this condition for over 2 months now and if it is in fact Thiamine deficiency I worry that maybe there is permanent damage to my kidneys.