In paediatric patients suffering from renal impairment, the dose will have to be adjusted on an individual basis taking into account the renal clearance of the patient, his age and his body weight. The distribution of pharmacokinetic parameters such as peak plasma concentration (Cmax) and area under curve (AUC), is unimodal in human volunteers. Objective tests as demonstrated by other studies have demonstrated that usual daily activities are unaffected at the recommended daily dose in healthy young volunteers. Symptoms observed after an overdose of cetirizine are mainly associated with CNS effects or with effects that could suggest an anticholinergic effect.

Galpharm Hay Fever and Allergy Relief 14 Tablets | medino

In addition to its anti-H1 effect, cetirizine was shown to display anti-allergic activities: at a dose of 10 mg once or twice daily, it inhibits the late phase recruitment of eosinophils, in the skin and conjunctiva of atopic subjects submitted to allergen challenge. Due to the pharmacokinetic, pharmacodynamic and tolerance profile of cetirizine, no interactions are expected with this antihistamine.The contact can be with your skin, mouth, gullet (oesophagus), stomach, intestine or with the lining of your lungs. Patients with moderate to severe renal impairment: there are no data to document the efficacy/safety ratio in patients with renal impairment. The decrease in cetirizine clearance in these elderly volunteers appeared to be related to their decreased renal function.

Hayfever Tablets For Dogs | Piriton | Antihistamines Hayfever Tablets For Dogs | Piriton | Antihistamines

Giving you relief for up to 24 hours, Galpharm Hay fever and Allergy Relief tablets help to soothe common hay fever symptoms: such as itchy or watery eyes, sneezing and a runny nose.The Piriton that its active substance is chlorphenamine maleate is a very reliable medicine that is intended for people, although many veterinarians use it regularly. Like all medication, Galpharm Hay fever and Allergy Relief Cetirizine Hydrochloride tablets may cause mild side effects in some people, such as drowsiness. To use this dosing table, an estimate of the patient’s cre­atinine clearance (CLcr) in ml/min is needed. Patients with hepatic impairment and renal impairment: dose adjustment is recommended (see Patients with moderate to severe renal impairment above). In sensitive patients, concurrent use with alcohol or other CNS depressants may cause additional reductions in alertness and impairment of performance.