Hurley, LL, et al. (2013). Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF. Historically, it’s mainly been used in Ayurvedic medicine, primarily in South Asia, for many conditions, including breathing problems, rheumatism, serious discomfort and fatigue. Chopra, A., Lavin, P., Patwardhan, B., and Chitre, D. A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees. J Clin Rheumatol. 2004;10(5):236-245. View abstract. One of the main drivers of this process is brain-derived neurotrophic factor (BDNF). This is a gene that’s involved in making a protein responsible for promoting the life of neurons.

Hu, Y., Du, Q., and Tang, Q. [Determination of chemical constituents of the volatile oil from Curcuma longa by gas chromatography-mass spectrometry]. Se.Pu. 1998;16(6):528-529. View abstract. Koosirirat, C., Linpisarn, S., Changsom, D., Chawansuntati, K., and Wipasa, J. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int Immunopharmacol. 2010;10(7):815-818. View abstract. Adhvaryu, M. R., Reddy, N., and Vakharia, B. C. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 8-14-2008;14(30):4753-4762. View abstract. Curcumin is also fat soluble, which means it breaks down and dissolves in fat or oil. That’s why it may be a good idea to take curcumin supplements with a meal that’s high in fat. Summary Zhang L, et al. (2006). Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients.

Agrawal, D. K., Saikia, D., Tiwari, R., Ojha, S., Shanker, K., Kumar, J. K., Gupta, A. K., Tandon, S., Negi, A. S., and Khanuja, S. P. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008;74(15):1828-1831. View abstract. Fan, C., Wo, X., Qian, Y., Yin, J., and Gao, L. Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol. 4-21-2006;105(1-2):251-254. View abstract. Ji, M., Choi, J., Lee, J., and Lee, Y. Induction of apoptosis by ar-turmerone on various cell lines. Int.J Mol.Med. 2004;14(2):253-256. View abstract.

Warfarin is used to slow blood clotting. Taking turmeric while taking warfarin might increase the effects of warfarin and increase the risk of bleeding and bruising.CUR had no significant effect on kidney function test in the present study. Consistently, serum levels of urea and creatinine not differed significantly comparing the pre- and post-turmeric supplementation in two clinical trials among patients with type 2 diabetic nephropathy [ 68] and chronic kidney disease [ 69]. Baliga, M. S., Jagetia, G. C., Rao, S. K., and Babu, K. Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. Nahrung 2003;47(4):261-264. View abstract. Mizoguchi Y, et al. (2020). Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study.