More human research and clinical trials are required before N. sativa and B. bulbocastanum can be heralded as cures. N. sativa in particular may pan out as a panacea for certain conditions. Test-tube studies have found some impressive results regarding the potential anti-cancer effects of kalonji and thymoquinone, its active compound. Heiss, Andreas (December 2005). "The oldest evidence of Nigella damascena L. (Ranunculaceae) and its possible introduction to central Europe". Vegetation History and Archaeobotany. 14 (4): 562–570. CiteSeerX 10.1.1.156.85. doi: 10.1007/s00334-005-0060-4. JSTOR 23419312. S2CID 18895456.

el Dakhakhny, M., Mady, N., Lembert, N., and Ammon, H. P. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med 2002;68(5):465-466. View abstract.

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Aljabre, S. H., Randhawa, M. A., Alakloby, O. M., and Alzahrani, A. J. Thymoquinone inhibits germination of dermatophyte arthrospores. Saudi Med J 2009;30(3):443-445. View abstract. In the United States, the Food and Drug Administration classifies Nigella sativa as Generally Recognized as Safe (GRAS) for use as a spice, natural seasoning, or flavouring. [12] History [ edit ]

Additionally, while some animal studies have found that kalonji can be safely consumed during pregnancy, one animal study found that the oil could slow down uterine contractions when used in large amounts. Overexpression of NF-κB in kidney tissue; ↓apoptotic cells; subdued lipid peroxidation; ↓SOD, GPx, and CAT activities in kidney tissue Hosseinzadeh, H., Parvardeh, S., Nassiri-Asl, M., and Mansouri, M. T. Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monit. 2005;11(4):BR106-BR110. View abstract.Serum creatinine, BUN and ↑BBM enzyme activities in kidney cortical and medullary homogenates and BBMV; carbohydrate metabolism enzyme activities, and in the enzymatic and non-enzymatic antioxidant parameters toward normalcy