Conrad A, Hansmann C, Engels I, Daschner FD, Frank U. Extract of Pelargonium sidoides (EPs 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro. Phytomedicine. 2007;14(Suppl 6):46–51. However, due to the potential effect of Kaloba on coagulation parameters, this product may enhance the effect of coagulation-inhibiting drugs such as warfarin and should not be taken concomitantly with these drugs. (see section 4.3). 4.6 Pregnancy and lactation

Tablet core: Maltodextrin, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, precipitated silica, magnesium stearate.While most patients taking tablets did not notice a particular taste, half of the participants taking the liquid noticed a particular taste which was described as “ bitter –sour”, “ unusual fruity”, “ like it was a root extract… very organic … a nice change”, “ mildly strange”, “ something like Bach’s flowers rescue remedy”, “ evil and gross”. Patients were asked whether they thought they had taken the real trial medicine or the placebo. About a third of patients thought they might have had the real medicine (because of the unusual taste, because they felt better, or had an adverse effect). About a third of patients thought they might have had the placebo (because they did not feel any improvement in their symptoms). Seven patients had no idea and could not tell either way. Three patients had not understood that they could be given a placebo. “ I am a bit worried about this dummy business. Are you saying you are giving some people pills that you know don’t work?”. Overall blinding appeared to be successful in the 29 patients included in the qualitative study – only 50% of those on active liquid, and fewer than 50% in the other groups, correctly guessed their allocation, no more than would be expected by chance. Almost all based their guess on whether or not they felt they had improved, rather than on the appearance or taste of the medicine. Pelargonium sidoides DC (Geraniaceae) root extract, EPs®7630 or “Kaloba®”, is a widely used herbal remedy for respiratory infections, with some evidence of effectiveness for acute bronchitis. However, it is not yet widely recommended by medical professionals in the UK. There is a need to undertake appropriately designed randomised trials to test its use as an alternative to antibiotics. The aim was to assess the feasibility of conducting a double-blind randomised controlled trial of Pelargonium sidoides root extract for treatment of acute bronchitis in UK primary care, investigating intervention compliance, patient preference for dosage form and acceptability of patient diaries. Study design

film-coated tablet contains 20 mg of extract (as dry extract) from the roots of Pelargonium sidoides DC (1 : 8 – 10) (EPs® 7630) Extraction solvent 11% ethanol (w/w). Kaloba is of pharmaceutical quality and has been manufactured to European Good Manufacturing Practice (GMP) GuidelinesWillcox M, Donovan E, Hu X-Y, Elboray S, Jerrard N, Roberts N, et al. Views regarding use of complementary therapies for acute respiratory infections: systematic review of qualitative studies. Complementary Therapies in Medicine. 2020;50:102382. This medicinal product does not require any special storage conditions. 6.5 Nature and contents of container