Health Technology Inquiry Service (HTIS). Use of AmniSure to assess possible premature rupture of fetal membranes in a pregnancy: Diagnostic accuracy, cost-effectiveness, and guidelines. Health Technology Assessment HTA. Ottawa, ON: Canadian Agency for Drugs and Technologies in Health (CADTH); March 15, 2010.

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Functional placental magnetic resonance imaging for evaluation of infection/inflammation in women with preterm premature ROM American College of Obstetricians and Gynecologists (ACOG). Practice Bulletin No. 217. Prelabor Rupture of Membranes. Obstet Gynecol. 2020;135(3):e80-e97. But if you’re less than 37 weeks pregnant and it’s determined to be PPROM, your healthcare professional may opt to stall delivery until your baby is better developed. They may also recommend giving you steroid injections to help your baby’s lungs mature.https://www.chop.edu/conditions-diseases/premature-rupture-membranes-prompreterm-premature-rupture-membranes-pprom An evidence review of methods to diagnose rupture of membranes by Caramore and Dresang (2011)concluded that, where diagnosis is essential and conventional testing proves equivocal, amniocentesis with injection of indigo carmine dye is the most definitive test. The authors stated that the most widely available of the newer biochemical assays, thePAMG-1 assay, appears to offer improved accuracy compared with conventional methods, but the clinical significance of a positive test, particularly in the setting of labor, is unclear.

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Lee SM, Lee J, Seong HS, et al. The clinical significance of a positive Amnisure test in women with term labor with intact membranes. J Matern Fetal Neonatal Med. 2009;22(4):305-310. Language services can be provided by calling the number on your member ID card. For additional language assistance:Because an examination of the amniotic fluid can only be performed at a relatively late stage of pregnancy, it is no longer possible to perform suction or curettage in the event of a positive examination. This means that an artificial miscarriage must be induced. Labor-promoting preparations are used in this case. For the pregnant woman, such a measure is extremely stressful both emotionally and physically and can be associated with serious psychological consequences. It is therefore often advisable to seek psychological or psychotherapeutic treatment. Performing Amniocentesis “On Your Own” With A Urine Test Strip