Shyam Saran, former foreign secretary, Government of India, and former special envoy for the Prime Minister for nuclear issues and climate change I roll my eyes, “Morning Gabe.” Tactfulness wasn’t his strong suit, but at least I could rely on him to tell me the truth. My mother.” She swallowed, fighting to get the words out. “She was the daughter of a preacher and she made it clear to me that a good girl doesn’t like sex. Sex is something that was to be endured and not sought out. So I wanted to be a good girl, and even though I had boyfriends, I couldn’t let my mother’s words go after hearing them for so long. But...” Her eyes slid down his body. She was afraid to continue.

Once more she felt the jolt of hurt at his words, but kept her features impassive, not wanting to give him the satisfaction of seeing her upset, her mouth clenched tightly shut, her mind struggling to accept what was going on. For the first time she realised that deep down she felt that he would not really force her into his bed - that he was only trying to humiliate her. The man she knew six years ago was fair and held in high esteem by the other contractors and employees. Did he not realise he had humiliated her enough? India is on the wrong side of history,’ declared President Bill Clinton post New Delhi’s nuclear tests in 1998 and came down with an array of sanctions. Cut to the present, India is no longer the enemy for the US. In an age dominated not just by China’s rise but by its undoubted political and economic muscle power, India has become the fashionable new ally in Washington. The phone call that came from April as she entered her apartment later that night was far from unexpected.Wide-eyed she could only stare up at him as he repeated more determinedly, his fingers digging slightly deeper pulling her from her reverie, “Do you find me attractive Tia?” She knew she should pull herself from him, tell him that she found him disgusting and to demand he leave, but there was something about his words, an honesty which she had never before experienced, her eyes closing softly, a moan leaving her mouth “Of course I find you attractive...What woman wouldn’t, but...I am just not comfortable with...” If the research request is approved, the company first conducts phase 1 clinical trials to determine that the drug is safe in small doses in healthy volunteers. If the drug proves to be safe for humans, the company launches phase 2 clinical trials to gather information on dosage, side effects and efficacy for particular conditions. These are typically smaller-scale randomised controlled trials where people are selected at random to take the drug or an alternative treatment or placebo.

Even after NICE has recommended the use of a new drug, and NHS England has completed any subsequent negotiations on prices, there may still be a delay before clinicians start to prescribe a drug as part of routine practice. Clinicians need to learn about a new drug, to incorporate new clinical guidelines in their practice or, in some cases, need additional training to become confident in prescribing it safely. She saw the hardness once more return to his features, his fingers gripping her tighter. “You are exactly who I think you are Sara. Did it give you pleasure to fire me all those years ago, when I told you I was innocent - to accuse me of being a thief? Did it make you feel good? Because now it is my turn and believe me, I am going to enjoy this” With that he hauled her hard up against himself, his mouth taking hers in a punishing kiss, her whimper lost as she tried in vain to push him away, his arms moving around her waist, holding her tightly to him.

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Sleep, sweetheart. If you want to help me, then sleep.” Far easier than she thought with the feel of Paul around her, she did. Only allowing herself a moment for a steady breath, Laura pushed the door open. Wow, Kelly had not been exaggerating when she said he was gorgeous. He was tall, dark, and handsome. He was tall and broad, just over six foot, with dark brown hair with a slight wave to it, and a complexion the color of honey went well with eyes the color of melting chocolate. A straight nose above a sensual mouth and cheekbones prominent below a broad forehead screamed male model. He was a fantasy come to life. I groan as I hear my alarm go off. I feel a migraine splitting my head apart as I reach around for my phone. Where did I put it? I feel around for it until I feel it on the floor next to the bed. The last thing I see is the empty eyes of my mate before I lose consciousness. The last coherent thought I have is knowing that I’m alone. The very first time she meets him she knows he’s what she wants, what she needs. It will be mutually beneficial for the both of them. Hot, satisfying sex on tap for the both of them. That’s all she wants, all she’s looking for, right? Falling in love isn’t on the agenda, for either of them.

Kimberly White got a job in one of the biggest company in Germany after she ran away from her stepfather and stepbrother who made life miserable for her. Companies can typically set high prices for a patented new drug on release, particularly if there are no alternative treatments for the condition. If other companies launch effective new treatments while a drug is in patent, the incumbent may then be forced to reduce prices if it wants to continue selling its drug in large volumes. However, it is only when the patent expires that companies can start manufacturing and selling generic versions of the drug (a medicine with the same active pharmaceutical ingredient as the originator drug) or a biosimilar version for more complex drugs (a medicine that doesn’t have any clinically meaningful differences from the originator drug). When generics or biosimilars enter the market, prices go down and the originator’s profits typically drop rapidly. No. If you can’t come then neither can I. You are too sore. This is the price I have to pay for not taking care of you.” Seema Sirohi has used her thirty-year experience in Washington, and deep knowledge of India and the US to write an accurate, accessible and timely account of the relationship. Mindful of pitfalls, past and future, this is not purely an optimistic tome, though it does show the good that diplomacy and political will can achieve. Friends with Benefits is well worth reading to make sense of an increasingly important relationship in a constantly changing and troubled world.’ Cut to the present, and the geopolitical arena is dramatically different. The US no longer sees India as an adversary but as an indispensable partner. China’s determined rise has significantly changed Washington’s strategic calculus. Today the US is busy trying to retain its pre-eminent position in the world by creating new friendships and alliances.

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There are, in addition, a few special arrangements that might allow patients to receive an expensive drug on the NHS even if NICE has not approved it. One is for the pharmaceutical company to reach an agreement with a funding body such as NHS England to provide a drug at a discount, or to reach another type of commercial arrangement, before the drug has completed NICE’s appraisal process successfully. These arrangements have become increasingly important as the NHS, companies and regulators have been encouraged to speed up the approval for new drugs. In some cases, the arrangements have allowed firms to collect additional evidence on the drug’s effectiveness to present to NICE during the technology appraisal process. In some of these schemes, these arrangements allow the pharmaceutical company to gather stronger evidence of the cost-effectiveness of the drug so that it can secure NICE approval at a later stage.

Since its establishment, NICE has recognised the case for considering a broader range of ethical perspectives in its decision-making. As it explains in its note on decision-making principles, ‘NICE believes that overall population needs are paramount in determining the fair allocation of resources. But it also recognises that in some circumstances, in the interests of fairness, the needs of particular groups may override those of the broader population.’ Once a research institute or pharmaceutical company discovers a new drug, there is still a long way to go before it can be sold to health services or the population. First, the drug needs to go through a battery of laboratory and animal tests to make an initial assessment of its safety. After these tests, the organisation must then apply to the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom (UK) for permission to conduct clinical trials on humans. Clinical trials are carried out in three ‘phases’. Flinching, she bit her tongue and then exhaled. “When I moved in with Jeff, he said it was because it made sense. It was supposed to be for us to save for the wedding. It was the smart thing to do. Three years later and a week before a wedding ceremony that was going to be done downstairs in the freaking basement just so he could shut me up, I found him in bed with someone else. I found out then he only asked me to marry him because he knew I wouldn’t have sex with him until he made a commitment.Now that is a good best friend.” Paul snuggled her closer, and she was thankful for the dark, because she couldn’t hide how much she felt for him in that moment.