Yadav et al. ( Reference Yadav and Verma 123 ) have shown that garlic in low doses is safe in frogs. They suggested that garlic extract has some beneficial effects on heart rate, rhythm and force of contraction, but very high doses may exert non-desirable effects as well. The comparative toxic effects of oral and intraperitoneal administration of garlic extracts on lung and liver tissue of rats have also been studied. Administration of a low dose of garlic (50 mg/kg per d) to rats either orally or intraperitoneally had little effect on lung and liver tissues as compared with control animals ( Reference Alnaqeeb, Thomson and Bordia 116 ). In contrast, administration of a high dose of garlic (500 mg/kg per d) resulted in profound changes in lung and liver tissues of rats. Moreover, intraperitoneal administration of a high dose of garlic was more damaging to lung and liver tissues of rats than oral administration. Therefore, these reports highlight some of the adverse and toxic effects of high doses of garlic in animals. In support to this, it has been shown that higher concentrations of garlic extract are clastogenic in mice ( Reference Das, Roychoudhury and Sharma 124 ), which was appreciably reduced at lower concentrations. Female and male rats were given 300 and 600 mg/kg per d of a garlic aqueous extract for 21 d and the results showed that garlic extract causes toxic effects affecting weight growth, biological parameters and histological structures in rats ( Reference Fehri, Aiache and Korbi 117 ). Banerjee et al. ( Reference Banerjee, Maulik and Manchanda 118 ) also studied the effects of chronic fresh garlic homogenate in three different doses (250, 500 and 1000 mg/kg per d) for 30 d on various endogenous antioxidant enzymes and lipid peroxidation in two major organs, the liver and kidney. It was observed that in comparison with saline-treated rats, the 250mg/kg per d dose significantly reduced the lipid peroxidation levels and increased SOD activity significantly. But higher doses of garlic (500 and 1000 mg/kg per d) significantly reduced endogenous antioxidants (catalase and SOD) without altering lipid peroxidation levels. A 1000 mg/kg per d dose of garlic caused marked histopathological and ultrastructural changes in both liver and kidneys. Thus, garlic in low doses has the potential to enhance antioxidant status, although at higher doses a reversal of these effects is observed. Garlic has the potential ability with a high dose to induce morphological changes in the liver and kidneys, indicating the need to identify a safe dose range for garlic. Prolonged feeding of high levels of raw garlic in rats has resulted in anaemia, weight loss and failure to grow due to the lysis of erythrocytes ( Reference Augusti 38 ). Raw garlic juice at a dose of 5 ml/kg has resulted in the death of rats due to stomach injury ( Reference Nakagawa, Masamoto and Sumiyoshi 125 ). Surviving rats exhibited swelling of the liver, hypertrophy of the spleen and adrenal glands and the decrease of erythrocyte count with various morphological changes after 3 and 8 d. Chen et al. ( Reference Chen, Hong and So 126 ) have also reported that treatment of rats with fresh garlic homogenate for 7 d caused a significant decrease in liver catalase activity in doses of 2 and 4 g/kg per d. Garlic oil fed to rats at a dose of 100 mg/kg per d in fasting conditions has also been found to be lethal. The cause of death appears to be acute pulmonary oedema with severe congestion ( Reference Joseph, Rao and Sundaresh 127 ). Garlic oil and DADS (200 mg/kg) significantly reduced the body-weight gain of rats ( Reference Sheen, Chen and Kung 128 ). One possible explanation for all the above-mentioned toxicity reports is that the sulfoxides present in garlic extract undergo exchange reactions with –SH groups of enzymes and other proteins in the body at physiological pH and temperature, so inhibiting their activity ( Reference Banerjee and Maulik 129 ). Most fermentation takes place in a warm, humidity-controlled environment where garlic is left for several weeks. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Lissiman E, Bhasale AL, Cohen M. Garlic for the common cold. Cochrane Database Syst Rev. 2014;2014(11):CD006206. doi:10.1002/14651858.CD006206.pub4 Sripanidkulchai B. (2020). Benefits of aged garlic extract on Alzheimer’s disease: Possible mechanisms of action.

Shanmugam KR, Shanmugam B, Subbaiah GV, Ravi S, Reddy KS. Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances in Drug Discovery. Curr Pharm Des. 2021;27(6):763-774. doi:10.2174/1381612826666200928160357 Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review. J Nutr. 2016;146(2):389S-396S. doi:10.3945/jn.114.202192 K. Song et al., Journal of Nutrition: "The Influence of Heating on the Anticancer Properties of Garlic."Garlic pearls capsules have improved my cardiovascular health significantly. My cholesterol levels have also decreased since I started taking them regularly.' - Rajesh Sharma, Engineer, 45 Finally, we also provide mixed-ingredient products, such as Bional Garlic, Olive Leaf & Hawthorn 80 Capsules. Asian countries like Japan, Thailand and South Korea have been using it for centuries – with each country having their own take on the fermentation process.

Garlic and its constituents protect tissue against oxidative damage and improve organ functions in various animal models ( Reference Park, Ki and Ko 36 ). In male Wistar rats, administration of garlic extract against nicotine hydrogen bitartrate for 21 d increased glutathione levels and decreased malondialdehyde levels in aorta, heart, kidney and urinary bladder tissues ( Reference Sener, Sehirli and Ipçi 37 ). Aqueous garlic administration protects the tissues against nicotine-induced oxidative damage and improves renal function and histological damage. Similarly, oral administration of garlic oil in carbon tetrachloride-intoxicated rats significantly decreases the tissue lipid profile, lipid peroxidation levels, alkaline phosphatase, serum transaminases and protects the liver from damage by carbon tetrachloride as effectively as vitamin E. These changes induced by garlic oil in these rats are comparable with that of vitamin E ( Reference Augusti 38 ). DAS, DADS and DATS are principal constituents of garlic. The effect of these sulfides on phase II drug-metabolising enzymes and on the rat model of acute liver injury induced by carbon tetrachloride has been studied. A highly purified form of each sulfide was administered to rats at a concentration of 10 or 100 μmol/kg body weight for 14 consecutive days. DATS (10 μmol/kg) and DADS (100 μmol/kg) significantly increased the activities of GST and quinone reductase, whereas DAS did not. In the rat model of carbon tetrachloride-induced acute liver injury, DATS (10 μmol/kg) significantly suppressed the increase in plasma lactate dehydrogenase and serum glutamate oxaloacetate transaminase activities. Therefore, hepatic phase II enzymes were induced strongly by the trisulfide and weakly by the disulfide, but not by DAS. DATS significantly reduced the liver injury caused by carbon tetrachloride. DATS may be one of the important factors in garlic oil that protects our body against the injury caused by radical molecules ( Reference Fukao, Hosono and Misawa 39 ). K. Reid et al., Integrated Blood Pressure Control, "Potential of garlic ( Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance." Other compounds that may play a role in garlic’s health benefits include diallyl disulfide and s-allyl cysteine. Doma K, Devantier-Thomas B, Gahreman D, Connor J. Selected root plant supplementation reduces indices of exercise-induced muscle damage: s systematic review and meta-analysis. Int J Vitam Nutr Res. 2020;1-21. doi:10.1024/0300-9831/a000689 Rouf F, et al. (2020). Antiviral potential of garlic ( Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data.Mondal A, Banerjee S, Bose S, et al. Garlic constituents for cancer prevention and therapy: from phytochemistry to novel formulations. Pharmacol Res. 2021;105837. doi:10.1016/j.phrs.2021.105837 Allicin is considered one of garlic’s most important active compounds, and it’s what gives garlic that distinctive taste and smell. 4Scientists think allicin is antibacterial and anti-fungal. 5

Medical research links garlic to a number of health benefits. However, some studies have suggested that raw garlic may be more effective than the cooked version, while garlic supplements are the most effective. Garlic tea retains the health benefits of raw garlic, as long as it is prepared properly: the key is boiling your crushed garlic no longer than 3 minutes. De Greef D, Barton EM, Sandberg EN, et al. Anticancer potential of garlic and its bioactive constituents: a systematic and comprehensive review. Semin Cancer Biol. 2021;73:219-264. doi:10.1016/j.semcancer.2020.11.020 Garlic, from the Allium family, is a close relative to onion, shallots, leeks, and chives, can be used for more than just seasoning food and making buttery, oven-toasted bread amazing. Ask your health care provider any questions you may have about how to use Garlic Pearls.There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it. Ried K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integr Blood Press Control. 2014;7:71-82. Published 2014 Dec 9. doi:10.2147/IBPC.S51434

Key ingredients

Hwang KA, et al. (2019). Effects of low temperature-aged garlic on exercise performance and fatigue in Mice. At present, there are no known toxic compounds in garlic and its extracts. Chronic administration of garlic powder (50 mg/d) resulted in inhibition of spermatogenesis in rats. Reduced concentration of sialic acid in the testes, epididymis and seminal vesicles together with decreased leydig cell function reflect anti-androgenic effects of garlic ( Reference Augusti and Mathew 113 ). A higher concentration of garlic powder (200 mg/ml) or allicin isolated from garlic caused considerable cell injuries in the portal hepatic zone in isolated perfused rat liver ( Reference Dixit and Joshi 114 ), which was not observed at a lower concentration.

Short-term garlic supplementation may have a protective role in hypertensive patients and on indices of oxidative stress. Garlic pearls at a dose of 250 mg/d for 2 months in hypertensive patients were found to decrease lipids and lipoprotein subfractions, plasma-oxidised LDL, plasma and urinary concentrations of 8-iso-PG F2α as a biomarker of oxidative stress and increase total antioxidant status. With 2 months of garlic pearl supplementation, there was also a significant decline in both systolic and diastolic blood pressures. It could be suggested that dietary supplementation of garlic may be beneficial in reducing blood pressure and oxidative stress in hypertensive individuals ( Reference Dhawan and Jain 46 ). Answer: No, you should not. It is recommended to take 1-2 capsules per serving or as directed by your doctor.Regulates Blood Sugar Levels: Garlic pearls may aid in regulating blood sugar levels, making them beneficial for individuals with diabetes or those at risk of developing the condition.