In addition, we warn of the presence of any one of over 100 ingredients that can potentially itch, irritate and even cause dandruff themselves. A significant number (~90%) of these chemicals have never been tested for their effect on human health. Many of these chemicals are known to have adverse effects on our skin and one of these adverse effects is dandruff. Adult: 200 mg once daily; may increase to 400 mg once daily if clinical response is insufficient. Continue treatment until symptoms have cleared and cultures have become negative.

Hypersensitivity to ketoconazole or any of the other ingredients of the preparation. 4.4 Special warning and precautions for use If not, please let us know in the comments below which shampoos you’d like us to take a look at! How we chose the winners Dandrazol 2% shampoo contains the active ingredient ketoconazole, which is a type of medicine called an antifungal. It is used to treat skin infections with fungi and yeasts.

Dosage

Ketoconazole does not appear to be appreciably absorbed systemically following topical application of a 2% shampoo to skin. Ketoconazole was notdetected in plasma of patients receiving topical application of 2% shampoo 4-10 times weekly for 6 months, or in patients using 2% shampoo 2-3 timesweekly for an average of 16 months. Following a single topical application,substantial amounts of the drug were detected in hair 12 hours afterapplication; however only 5% of the applied ketoconazole was detected in hairkeratin. Following repeated (twice weekly for 2 months) application, 20% ofthe applied dose was detected in hair keratin. 5.3. Preclinical safety data

Van Cutsem, J. (1983). The antifungal activity of ketoconazole. The American journal of medicine, 74(1), 9-15. Apply a generous amount of shampoo to wet hair and massage it into the scalp. Leave the shampoo for three to five minutes and then rinse the shampoo. Regenepure DR shampoo is suitable for everyday use. Because of the 1% Ketoconazole, your hair can feel dry when you use the shampoo every day. You can then choose to reduce the frequency (3-4 times per week) and to not wash your hair on the other days. Use a condtioner if desired, preferably Regenepure biotin conditioner. Ketoconazole is one of the few active ingredients to be listed as an official anti-dandruff treatment both in the UK and the USA. Excessive use of alcohol or products containing alcohol together with ketoconazole or levoketoconazole may potentiate the risk of liver injury.Yet despite it being so effective, only 4% of the shampoos reviewed contain the ingredient. Making it the rarest, along with selenium sulfide, established anti-dandruff active ingredients. In rare cases, ketoconazole shampoo can result in hair loss, so talk to your doctor right away if you notice this side effect. Signs of allergic reaction Massage the shampoo into the hair like normal shampoo, but leave it on for three to five minutes before rinsing. In vitro studies using ketoconazole in a microbial system (i.e., Ames test) have not shown the drug to be mutagenic. In addition, there was no evidence ofmutagenicity in any stage of germ cell development in a dominant lethalmutation test in mice who received single oral doses of ketoconazole as highas 80 mg/kg. There was no evidence of carcinogenicity in a long-term feedingstudy in mice and rats. Hepatotoxicity featured prominently in high dosetoxicology studies in animals and occurs in about 1 in 10,000 patients. 6 PHARMACEUTICAL PARTICULARS 6.1 List of excipients

This medicine is not absorbed into the bloodstream from the skin and can be safely used during breastfeeding. Treatment of: Use Dandrazol 2% shampoo twice weekly for 2-4 weeks. Prophylaxis of: Use Dandrazol 2% shampoo once every 1-2 weeks. Ketoconazole can have negative side effects that you should be aware of before using it. One of the most common side effects is skin irritation, which can take the form of pimple-like bumps where it’s used. In some individuals, it may also cause either oiliness or dryness of the hair or scalp, abnormal hair texture, or discoloration. It can cause permed hair to lose its curl as well. Prevention and treatment of infections in which the yeast Pityrosporum is likely to be involved, such as dandruff, seborrhoeic dermatitis and pityriasisversicolor. 4.2 Posology and method of administration EMC. (2015). Pinewood Healthcare: Ketoconazole 2% w/w Shampoo. [Accessed: 28/2/17] www.medicines.org.ukChild: ≥2 yr 3.3-6.6 mg/kg once daily. Treatment duration: 1-2 wk for candidiasis; at least 4 wk in recalcitrant dermatophyte infections and up to 6 mth for other systemic mycoses. Ketoconazole shampoos are also available without a brand name, ie as the generic medicine. Further reading Ketoconazole shampoo can also treat tinea capitis and tinea versicolor. Tinea capitis is a superficial, ringworm-like fungus infection that affects the scalp. Tinea versicolor is a skin infection that’s caused by an overgrowth of a type of yeast that naturally lives on your skin. Hair loss

Dandrazol 2% shampoo should be used to wash the affected areas as below. Leave the shampoo on for three to five minutes before rinsing. Take care to avoid getting the shampoo in the eyes. If it does enter the eyes, rinse immediately with plenty of water. Prophylaxis of: As patches of pityriasis versicolor become more apparent on exposure to the sun, Dandrazol 2% Shampoo may be used once daily for a maximum of 3 daysin a single treatment course before exposure to sunshine. 4.3 Contraindications Personally, I think it’s about time the US followed suit… Common brand names of ketoconazole shampoos

Volume of Distribution

There are no adequate and well-controlled studies in pregnant or lactating women. Data on a limited number of exposed pregnancies indicate no adverse effects of topical ketoconazole on pregnancy or on the health of the foetus/newborn child. Animal studies have shown reproductive toxicity at doses that are not relevant to the topical administration of ketoconazole No effects on the breastfed newborn/infant are anticipated. See Pharmacokinetic properties, section 5.2.