Due to the widespread use of MK-7-containing supplements, the pharmacokinetics following single intake of MK-7 from various formulations was assessed in four parallel studies. In humans, anaerobes like Escherichia coli present in large intestine synthesizes long chain derivatives of menaquinones (MK-7 to MK-11). High Dephosphorylated-Uncarboxylated MGP in Hemodialysis Patients: Risk Factors and Response to Vitamin K2, A Pre-post Intervention Clinical Trial.

This implies a strong beneficial effect of K2-7 circulating levels in reducing the risk of fractures globally. Further, we discuss the current status of clinical trials on K2-7 that shed light on dosing strategies for maximum health benefits. Various factors affect the production of vitamin K2-7 in SSF such as the microbial strain used, raw material or substrate along with its pre-treatment, temperature and time for which the fermentation is run. Source of claims: Commission Regulation (EU) No 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children’s development and health. gov/ct2/show/ {"type":"clinical-trial","attrs":{"text":"NCT03305536","term_id":"NCT03305536"}}NCT03305536 (Accessed October 7, 2021).

VitaMK7® is a natural vitamin K2 in the form of MK-7 with a very high level of purity: it contains >99% menaquinone-7 (MK-7) all-trans, the only active form of vitamin K2 that does not contain any impurities of various origins. Safety and Efficacy of Vitamin K Antagonists versus Rivaroxaban in Hemodialysis Patients with Atrial Fibrillation: a Multicenter Randomized Controlled Trial.

Vitamin K2-7, also known as menaquinone-7 (MK-7) is a form of vitamin K that has health-beneficial effects in osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer’s disease, diabetes and peripheral neuropathy. Vitamin K2 helps in carboxylation of glutamate (Glu) residues present on VKDPs to γ-carboxyglutamate (Gla) which results in their activation. The newly synthesized osteocalcin is inactive and it requires vitamin K2-7 for converting itself into active form by carboxylation, and later bind to calcium ( Hauschka et al. Osteocalcin signaling pathway regulated glucose metabolism which led to an increase in insulin1 (Ins1) and insulin2 (Ins2) gene expression ( Hussein et al. In addition, it was reported that PC-12 cells when treated with hydrogen peroxide and β-amyloid increased phospho-p38 MAP kinase, PARP cleavage and Bax/Bcl-2 ratio; while pre-treatment with vitamin K2 resulted in decreased phosphorylation of p38 MAPK, PARP cleavage and mRNA level of Bax/Bcl-2.PIVKA-II Serves as a Potential Biomarker that Complements AFP for the Diagnosis of Hepatocellular Carcinoma.