Balaban, R.S.; Nemoto, S.; Finkel, T. Mitochondria, oxidants, and aging. Cell 2005, 120, 483–495. [ Google Scholar] [ CrossRef] Vasavada, N.; Agarwal, R. Role of oxidative stress in diabetic nephropathy. Chronic Kidney Dis. 2005, 12, 146–154. [ Google Scholar] [ CrossRef] [ PubMed]

Nendoroid DIO - 株式会社グッドスマイルカンパニー Nendoroid DIO - 株式会社グッドスマイルカンパニー

A step-by-step calculation of days inventory outstanding is an easy approach that offers accurate figures and detailed analysis. Roghani-Dehkordi, F.; Roghani, M.; Baluchnejadmojarad, T. Diosgenin mitigates streptozotocin diabetes-induced vascular dysfunction of the rat aorta: The involved mechanisms. J. Cardiovasc. Pharmacol. 2015, 66, 584–592. [ Google Scholar] [ CrossRef] [ PubMed] DIO is calculated using average figures of inventory, cost of goods sold (or cost of sales), and the number of days in the accounting period. Usually, an annual figure of 365 days and average figures for the same annual accounting period are used in the DIO calculations. Zhong, Y.J.; Liu, J.Y.; Sun, D.J.; Guo, T.M.; Yao, Y.P.; Xia, X.D.; Shi, C.; Peng, X.L. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control. Food Funct. 2022, 13, 3660–3673. [ Google Scholar] [ CrossRef] Yuan, D.; Liu, X.M.; Fang, Z.; Du, L.L.; Chang, J.; Lin, S.H. Protective effect of resveratrol on kidney in rats with diabetic nephropathy and its effect on endoplasmic reticulum stress. Eur. Rev. Med. Pharmacol. Sci. 2018, 22, 1485–1493. [ Google Scholar] [ PubMed]Douglas, R.G.; Reed, J.C. Mitochondria and apoptosis. Science 1998, 281, 1309–1312. [ Google Scholar] [ CrossRef] Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495–516. [ Google Scholar] [ CrossRef]

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A company can use periodic lengths such as 90 days for quarterly calculations as well. However, care must be taken to include relevant inventory, COGS, and cost of sales figures for the same accounting period. Li, C.Y.; Deng, C.W.; Pan, G.Z.; Wang, X.; Zhang, K.; Dong, Z.; Zhao, G.C.; Tan, M.Q.; Hu, X.S.; Shi, S.M.; et al. Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer. J. Exp. Clin. Canc. Res. 2020, 41, 306. [ Google Scholar] [ CrossRef] [ PubMed]Ji, H.Y.; Zhang, K.; Pan, G.Z.; Li, C.H.; Li, C.Y.; Hu, X.; Yang, L.Q.; Cui, H.J. Deoxyelephantopin induces apoptosis and enhances chemosensitivity of colon cancer via miR-205/Bcl2 axis. Int. J. Mol. Sci. 2022, 23, 5051. [ Google Scholar] [ CrossRef] Alicic, R.Z.; Rooney, M.T.; Tuttle, K.R. Diabetic kidney disease: Challenges, progress, and possibilities. Clin. J. Am. Soc. Nephrol. 2017, 12, 2032–2045. [ Google Scholar] [ CrossRef] The formula for days inventory outstanding is as follows: Days Inventory Outstanding = (Average inventory / Cost of sales) x Number of days in period

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Zhong, Y.J.; Jin, C.N.; Han, J.H.; Zhu, J.C.; Liu, Q.; Sun, D.J.; Xia, X.D.; Peng, X.L. Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca 2+ homeostasis. Cell Biol. Toxicol. 2021, 37, 795–809. [ Google Scholar] [ CrossRef] [ PubMed] Hernandez, L.F.; Eguchi, N.; Whaley, D.; Alexander, M.; Tantisattamo, E.; Ichii, H. Anti-oxidative therapy in diabetic nephropathy. Front. Biosci. 2022, 14, 14. [ Google Scholar] [ CrossRef]

Yang, K.; Bai, Y.; Yu, N.; Lu, B.; Han, G.; Yin, C.; Pang, Z. Huidouba improved podocyte injury by down-regulating Nox4 expression in rats with diabetic nephropathy. Front. Pharmacol. 2020, 11, 587995. [ Google Scholar] [ CrossRef] [ PubMed] Geiszt, M.; Kopp, J.B.; Varnai, P.; Leto, T.L. Identification of Renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. USA 2000, 97, 8010–8014. [ Google Scholar] [ CrossRef] [ PubMed]