Ribeiro M, Alvarenga L, Cardozo LFMF, et al. From the distinctive smell to therapeutic effects: Garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease. Clinical Nutrition. 2021;40(7):4807-4819. doi:10.1016/j.clnu.2021.03.005 How is allicin extracted from garlic? Purified allicin is actually not sold commercially because it is not very stable. What are the side effects of allicin? Garlic supplements are generally safe and well-tolerated, but some side effects are still possible. Allicin stimulates lymphocytes by affecting p21 ras: Thioallylation that means the binding of an allyl sulfenic acid to the thiol of cysteine 118 leads to an activation of p21 ras and subsequently to stimulation of ERK1/2 phosphorylation. These processes are crucial for the activation of lymphocytes.

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Food Supplements are intended to supplement the diet and should not be substituted for a varied diet or healthy lifestyle. Several different types of garlic supplements are now available. Levels of organosulfur compounds that these supplements provide depends on how they were produced.Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review. J Nutr. 2016;146(2):389S-396S. doi:10.3945/jn.114.202192 Catanzaro E, Canistro D, Pellicioni V, Vivarelli F, Fimognari C. Anticancer potential of allicin: A review. Pharmacol Res. 2022;177:106118. doi:10.1016/j.phrs.2022.106118 It’s believed that the way garlic is prepared, and how allicin and other compounds are extracted, may explain this. S-allylcysteine on the other hand is bioavailable and has the ability to lower cholesterol, since it acts as an antioxidant and anti-inflammatory agent. Choo S, Chin VK, Wong EH, et al. Review: antimicrobial properties of allicin used alone or in combination with other medications. Folia Microbiol (Praha). 2020;65(3):451-465. doi:10.1007/s12223-020-00786-5

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I’m not going to leave you hanging! Yes, there actually is an allicin supplement that I can feel confident recommending. It is called Allimed in the United States and it is the one I used for treating SIBO. There are two main classes of organosulfur compounds found in whole garlic cloves: L-cysteine sulfoxides and γ-glutamyl-L-cysteine peptides.A 2014 study published in the journal Molecules states, “allicin can inhibit the proliferation of both bacteria and fungi, or kill cells outright, including antibiotic-resistant strains like methicillin-resistant Staphylococcus aureus (MRSA).” Effect of allicin on elongation of primary root growth: To investigate the effects of allicin on A. thaliana seedlings (accession Col-0), seeds were sown onto sterile filter paper which had been placed on Murashige & Skoog (MS) medium beforehand. After stratification (4 °C, 48 h), the Petri plates were cultivated at an angle approx. 20° from vertical to ensure unidirectional gravitropic root growth. For allicin exposure, the filter papers were transferred onto allicin-containing medium and 48 h after further cultivation, pictures were taken and the root lengths were measured using the software ImageJ [ 114]. The “boxplot” was prepared with the program PAST [ 115]; every dot represents the measurement of one root. The two halves of one box represent the 25 and 75 percent quartile, while the horizontal line in the middle shows the median. n = total number of measurements for the given treatment. Plate diffusion test. Antibacterial activity against E. coli DH5α demonstrated on seeded agar plates by different antibiotics is indicated by clear zones where growth inhibition has occurred. Freshly grown E. coli cells (OD 600 = 0.2, 300 µL) were embedded in 20 mL warm agar in a Petri dish (diameter 9 cm). Afterwards, holes (diameter 0.6 cm) were punched out and filled with 40 µL of antibiotic solution at the mM concentrations indicated. Pictures were taken after 24 h of incubation in the presence of the antibiotics. ( A) kanamycin; ( B) allicin; and ( C) ampicillin. Aged garlic extract is the only water-based garlic supplement, which makes it more bioavailable than most other forms. Aged garlic is also a popular form of garlic to use for supplementation since it does not have a strong garlic scent. While dosage recommendations vary depending on someone’s health, the most commonly used doses (such as for supporting cardiovascular health) range from of 600 to 1,200 milligrams per day of garlic powder, usually divided into multiple doses. This should equate to about 3.6 to 5.4 mg/day of potential allicin.

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There is a link between the functioning of the immune system and cancer. In an early study (1960), explants of mouse-tumours were incubated in allicin before implantation into healthy mice. In contrast to the control group (where the explants were not allicin-treated), mice with tumour explants incubated in allicin showed no further growth of the explant [ 102]. Haghi A, Azimi H, Rahimi R. A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer. J Gastrointest Cancer. 2017;48(4):314-320. doi:10.1007/s12029-017-9997-7 Isolation and testing of the organosulfur compounds from garlic for antimicrobial activity was carried out in the 1940s [ 9]. Neither DADS, directly formed by the decomposition of allicin, nor the diallylpolysulfanes showed any remarkable antimicrobial activity, unless used in very high concentrations. Koch and Lawson [ 5] determined the minimal concentration of organosulfur compounds found in crushed garlic needed to inhibit the growth of Escherichia coli and Staphylococcus aureus. According to their results, approximately 35× more DADS (6.15 mM) was needed to inhibit the growth of these two bacteria compared to allicin (0.17 mM).Experts consider the minimum effective dose for raw garlic to be a single clove, eaten with meals two or three times a day.