Storage & organisation Furniture Textiles Kitchenware & tableware Kitchens Lighting Decoration Rugs, mats & flooring Beds & mattresses Baby & children Smart home Bathroom products Laundry & cleaning Plants & plant pots Home electronics Home improvement Outdoor living Food & beverages Christmas Shop Shop by room PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysosome-associated membrane glycoprotein 1 poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins [11] Polylactosamine attachments which protect the glyocoprotein from degradation by lysosomal proteases [10]

To help you improve the lighting in your home, we have everything from ceiling to floor lamps, as well as all of the in-betweens. A lamp here, a lamp there Mane SM, Marzella L, Bainton DF, Holt VK, Cha Y, Hildreth JE, August JT (Jan 1989). "Purification and characterization of human lysosomal membrane glycoproteins". Archives of Biochemistry and Biophysics. 268 (1): 360–78. doi: 10.1016/0003-9861(89)90597-3. PMID 2912382. Fukuda M, Viitala J, Matteson J, Carlsson SR (Dec 1988). "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences". The Journal of Biological Chemistry. 263 (35): 18920–8. doi: 10.1016/S0021-9258(18)37370-8. PMID 3198605. Furuta K, Yang XL, Chen JS, Hamilton SR, August JT (May 1999). "Differential expression of the lysosome-associated membrane proteins in normal human tissues". Archives of Biochemistry and Biophysics. 365 (1): 75–82. doi: 10.1006/abbi.1999.1147. PMID 10222041.Rohrer J, Schweizer A, Russell D, Kornfeld S (Feb 1996). "The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane". The Journal of Cell Biology. 132 (4): 565–76. doi: 10.1083/jcb.132.4.565. PMC 2199866. PMID 8647888. a b Künzli BM, Berberat PO, Zhu ZW, Martignoni M, Kleeff J, Tempia-Caliera AA, Fukuda M, Zimmermann A, Friess H, Büchler MW (Jan 2002). "Influences of the lysosomal associated membrane proteins (Lamp-1, Lamp-2) and Mac-2 binding protein (Mac-2-BP) on the prognosis of pancreatic carcinoma". Cancer. 94 (1): 228–239. doi: 10.1002/cncr.10162. PMID 11815981. S2CID 12702437. A properly lit room should have between five to seven light sources. And ideally, they should be a mix of different types of lights, positioned throughout the room at varied heights and. By combining floor lamps, table lamps and wall lamps, it'll be easier for you to create perfect lighting and help your room come to life. Use height when deciding on indoor lighting Raposo G, Moore M, Innes D, Leijendekker R, Leigh-Brown A, Benaroch P, Geuze H (Oct 2002). "Human macrophages accumulate HIV-1 particles in MHC II compartments". Traffic. 3 (10): 718–29. doi: 10.1034/j.1600-0854.2002.31004.x. PMID 12230470. S2CID 7055266. Consider whether the lamp needs to be plugged in at all times or if it can be placed after being charged. Lamps that don’t require a power connection provide more flexibility in placement throughout the room and are often best for ambiance instead of utilitarian lighting.

a b c d e f Eskelinen EL (2006). "Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy". Molecular Aspects of Medicine. 27 (5–6): 495–502. doi: 10.1016/j.mam.2006.08.005. PMID 16973206.Höning S, Sandoval IV, von Figura K (Aug 1998). "A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3". The EMBO Journal. 17 (5): 1304–14. doi: 10.1093/emboj/17.5.1304. PMC 1170479. PMID 9482728. Lee N, Wang WC, Fukuda M (Nov 1990). "Granulocytic differentiation of HL-60 cells is associated with increase of poly-N-acetyllactosamine in Asn-linked oligosaccharides attached to human lysosomal membrane glycoproteins". The Journal of Biological Chemistry. 265 (33): 20476–87. doi: 10.1016/S0021-9258(17)30529-X. PMID 2243101. Zhang H, Li XJ, Martin DB, Aebersold R (Jun 2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nature Biotechnology. 21 (6): 660–6. doi: 10.1038/nbt827. PMID 12754519. S2CID 581283. Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Sawada R, Jardine KA, Fukuda M (Apr 1993). "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes". The Journal of Biological Chemistry. 268 (12): 9014–22. doi: 10.1016/S0021-9258(18)52972-0. PMID 8517882. Kima, P. E.; Burleigh, B.; Andrews, N. W. (Dec 2000). "Surface-targeted lysosomal membrane glycoprotein-1 (Lamp-1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi". Cellular Microbiology. 2 (6): 477–486. doi: 10.1046/j.1462-5822.2000.00071.x. ISSN 1462-5814. PMID 11207602. S2CID 19192092.Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. PMID 12144129.

LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, [6] and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. [6] [11] The expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. [11] The two are therefore thought to share similar functions in vivo. [6] However, this makes the determining the precise function of LAMP1 difficult, because while the LAMP1 deficient phenotype is little different than the wild type due to LAMP2 up regulation, [6] [11] the LAMP1/ LAMP2 double deficient phenotype leads to embryonic lethality. [11] Significant quantities of polylactosaminoglycan and sialic acid to traverse the trans- Golgi cisternae. [10] You want to make sure your lighting is positioned at varying heights. If not, your lamps might create an unflattering circle that directs all light towards the middle of the room. This can make the room feel smaller. Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. [11] Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. [12] Cell surface expression of LAMP1 can serve as a ligand for selectins [13] [14] and help mediate cell- cell adhesion. [15] Accordingly, cell surface expression of LAMP1 is seen in cells with migratory or invasive functions, such as cytotoxic T cells, platelets and macrophages. [16] Cell surface expression of LAMP1 and LAMP2 is also often seen in cancer cells, [16] [17] particularly cancers with high metastatic potential, such as colon carcinoma and melanoma, [16] and has been shown to correlate with their metastatic potential. [11] Role in cancer [ edit ] Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS (Sep 1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science. 269 (5232): 1872–5. Bibcode: 1995Sci...269.1872O. doi: 10.1126/science.7569928. PMID 7569928.Viitala J, Carlsson SR, Siebert PD, Fukuda M (Jun 1988). "Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000". Proceedings of the National Academy of Sciences of the United States of America. 85 (11): 3743–7. Bibcode: 1988PNAS...85.3743V. doi: 10.1073/pnas.85.11.3743. PMC 280294. PMID 3131762. a b c Jensen SS, Aaberg-Jessen C, Christensen KG, Kristensen B (2013). "Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas". International Journal of Clinical and Experimental Pathology. 6 (7): 1294–1305. PMC 3693194. PMID 23826410.