Eric Widmaier (Boston University), Hershel Raff (Medical College of Wisconsin), and Kevin Strang (University of Wisconsin) have taken on the challenge of maintaining the strengths and reputation of Vander's Human Physiology: The Mechanisms of Body Function. Moving beyond the listing of mere facts, it stresses the causal chains of events that constitute the mechanisms of body function. The fundamental purpose of this textbook is to present the principles and facts of human physiology in a format that is Vander's Human Physiology, thirteenth edition, carries on the tradition of clarity and accuracy, while refining and updating the content to meet the needs of today's instructors and students. The thirteenth edition features a streamlined, clinically oriented focus to the study of human body systems. It has also responded to reviewer requests for more clinical applications. Physiology Inquiries are maintained throughout the chapters. These critical-thinking questions associated with figures are just one more opportunity to add to the student's learning experience. Vander’s Human Physiology, twelfth edition, carries on the tradition of clarity and accuracy, while refining and updating the content to meet the needs of today’s instructors and students. The twelfth edition features a streamlined, clinically oriented focus to the study of human body systems. It has also responded to reviewer requests for more clinical applications. Chapter 19 was new for the eleventh edition, with three complete case studies. The twelfth edition will contain an additional new case study. Additional Physiology Inquiries have been added to many figures throughout the chapters. These critical-thinking questions are just one more opportunity to add to the student’s learning experience. Homeostasis: A Framework for Human Physiology Chemical Composition of the Body Cellular structure, proteins, and Metabolism Movement of Molecules Across Cell Membranes Control of Cells by Chemical Messengers Neuronal Signaling and the Structure of the Nervous System Sensory Physiology Consciousness, the Brain, and Behavior Muscle Control of Body Movement The Endocrine System Cardiovascular Physiology Respiratory Physiology The Kidneys and Regulation of Water and Inorganic Ions The Digestion and Absorption of Food Regulation of Organic Metabolism and Energy Balance Reproduction Defense Mechanisms of the Body Medical Physiology: Integration Using Clinical Cases.