Date standard updated: April 2022. FASP-S08: referral: timeliness to intervention (20-week screening scan) Description make sure laboratories have systems in place to comply with the FASP handbook guidance for the combined and quadruple screening tests In FASP-S02, the exclusion ‘women who are offered an appointment within the optimum time but choose to attend at a different time for personal reasons’ was moved to the subset of women left to follow up. This is because evidence shows this is masking inequalities in some services. The removal of this exclusion will have minimal impact on performance at an England level. FASP-S03: diagnosis/intervention: test turnaround time quantitative fluorescent-polymerase chain reaction (QF-PCR) Denominator: number of confirmed cytogenetic diagnoses of T18 and T13 following any result (higher or lower chance) from the combined test T21, T18, T13 combined test

FA4 was introduced in 2020 to 2021. New KPIs are not published in the first year of data collection. This time is used to improve the data quality and completeness, by revising the definition, adding clarity and / or setting thresholds as required. After this time, we will review the data with the aim of publishing it from the following year. 2. Infectious diseases in pregnancy screening 2.1 KPI ID1: HIV coverage Data to be collated quarterly, 2 quarters in arrears. Due to the potential lag time between early booking and ultrasound scanning, the complete cohort cannot be accounted for until 2 quarters later. provide a weekly failsafe process to make sure all screening results, including lower chance results, are communicated to women and the outcome of the discussion recorded All denominators above exclude samples referred for genetic testing where the only indication for testing is an increased NT. FASP recommends all women who accept first trimester screening must have all components of the screening test completed - NT and biochemistry. Performance thresholds All screening services who submitted data (137 out of 139) met the acceptable threshold of 90%, with 133 meeting the achievable threshold of 95% and 17 of them reporting performance of 100%.See the central glossary of terms, NHS population screening explained and NHS.UK for definition of terms. If you would like to see the meaning of an acronym, hover over it with your cursor and you will be able to see the full definition. Summary of changes from previous version of standards National performance of FA2 in Q1 2020 to 2021 was 99.3%, the highest ever level recorded for this key performance indicator (KPI0. FA2 is collected 6 months (2 quarters) in arrears. The national trend graph below shows that FA2 performance has remained above the achievable threshold of 95% since 1 April 2017. Please also read the general information relevant to all the NHS screening programme pathways. Down’s syndrome, Edwards’ syndrome and Patau’s syndrome screening If your firm carries out work that is subject to The Money Laundering, Terrorist Financing and Transfer of Funds (Information on the Payer) Regulations 2017 (the MLRs) you must make sure that you also apply for approval of any individuals listed on this form who are beneficial owners, officers and/or managers of your firm under the MLRs.

Denominator: number of samples for T21, T18, T13 screening received in the laboratory in the reporting period. Numerator: number of women referred locally and seen within 3 working days of the fetal anomaly scan FA4 was introduced in 2020 to 2021. New KPIs are not published in the first year of data collection. This time is used to improve the data quality and completeness by revising the definition, adding clarity or setting thresholds as required. After this time, we will review the data with the aim of publishing it from the following year. 2. Infectious diseases (IDs) in pregnancy screening 2.1 KPI ID1: HIV coverageThere is no intention to publish FA3 by individual maternity service. We are reviewing the data with the aim of publishing it national in the future.