Dropizol is not recommended during pregnancy unless the benefits clearly outweigh the risks to both mother and child. Opioid peptides modify the gastrointestinal (GI) function by interaction with opioid receptors on the enteric circuitries that control motility and secretion. Opioid receptors have been localized in the GI tract of humans, but their relative distribution varies with GI layer and GI region1. The product is a powder encapsulated. Delicol contains lactase, the enzyme that is responsible for breaking down lactose so it becomes more digestible. Lactose intolerance is a fairly common complaint encountered also in newborns and infants, many of them may be the main cause of infantile colic. Peak serum concentrations of morphine, the main alkaloid of the opium extract, are achieved within 2 to 4 hours after oral administration. Opium alkaloids (opioids and isoquinoline derivatives) induce constipation, euphoria, analgesia and sedation dependent on the dose and derivative.

Opium is excreted in human milk, where it reaches higher concentrations than in maternal plasma. A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Dropizol therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman. If Dropizol is used during breastfeeding, infants should be closely monitored for symptoms of respiratory depression and sedation. Amphetamine and analogues can reduce the sedative effect of opioids. Loxapine and periciazine can increase the sedative effect of opioids. Concomitant use of flibanserin and opioids may increase the risk of CNS depression. Opioids can increase the plasma concentrations of desmopressin and sertraline. The elimination half-life of morphine is approximately 2 hours. An elimination half-life of 2.4 to 6.7 hours has been reported for M3G. About 90 % of total morphine is excreted in 24 hours with traces in urine for 48 hours or more 9.Opium alkaloids are extensively metabolized to glucuronide conjugates (3-glucuronide (M3G) and 6-glucuronide (M6G)) that undergo an enterohepatic cycle. 6-glucuronide is a metabolite of morphine about 50 times more active than the parent substance.

These effects of are mediated by opioid receptors. The receptors are widely distributed in the central nervous system. Receptors are also present to a lesser extent, in vas deferens, knee joints, the gastrointestinal tract, and in the heart and the immune system.

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Use under medical supervision. From the first days of life until the end of 4 weeks of age: the contents of one capsule added to each serving of food. From 5 to 6 weeks of age: the contents of two capsules added to each serving of food. Over 16 weeks of age: add three capsules each serving of food. The capsule is not suitable for human consumption. Do not exceed recommended servings for consumption during the day. Morphine may precipitate coma in hepatic impairment – avoid or reduce dose. See Sections 4.3 and 4.4. The posology should be individualized to use the lowest effective dose for the shortest duration of time taking into account the patient's general condition, the patient's age, weight, and medical history (see sections 4.3 and 4.4).

Vì vậy, bổ sung enzyme lactase sẽ đem lại nhiều lợi ích trong việc cải thiện các tình trạng dưới đây: 1.1. Kém hoặc không dung nạp Lactose Treatment should be initiated and supervised by a specialist, i.e. oncologist or gastroenterologist.Delicol. Жените, които са бременни или планират да забременеят, трябва да се консултират предварително с лекаря си. Delicol – взаимодействия Should only be used with caution in patients in high-risk groups, such as patients with epilepsy and hepatic disease. There is limited amount of data from the use of opium in pregnant women. Studies in animals have shown reproductive toxicity (see section 5.3).