In the category of computational resources, ProbeMiner serves as a source for objective, quantitative, data-driven probe assessment. These two databases can be viewed as complementary to each other. Searching for a stolen statue of Kali, Grover finds himself battling an apparent resurgence of the Cult of Thugs. Includes two scenes with Cameron outside Probe Control, and the only on-screen appearance of the Probe Control briefing narrator, played by Vernon Weddle, whose voice is heard in other episodes and the pilot movie. Early in the series the Probe Control set was placed in a darkened isolated space, alluding to a large-scale operations center. By the middle of the season, the control room was scaled down and relocated to a well-lit but smaller "bunker" room. According to the show's credits, the computer equipment was provided by Control Data Corporation. Match Game / Bob Keeshan / Gumby / The Flip Wilson Show / Glen Campbell Goodtime Hour / The Bobby Darin Show / The Richard Pryor Show / George Burns / Celebrity Commercials

Z. Feng, D. Kallifidas and S. F. Brady, Proc. Natl. Acad. Sci. U. S. A., 2011, 108, 12629–12634 CrossRef CAS PubMed. Our tool will automatically select the “Custom Ports” when you access it. You must manually enter each port number you’d like to scan. The show was created by Leslie Stevens, and produced by Stevens, Robert H. Justman, John Strong [2] and Anthony Spinner. [3] The high concept was described as "science fiction in today's world" and the episodes featured many high-tech elements which are now considered common in current science fiction shows. The apparent suicide of an alleged embezzler, whose widow hires Probe to investigate, leads Bianco to infiltrate a most unusual travel agency: a front for a criminal counterpart to the Witness Protection Program. Diana Muldaur and Sebastian Cabot are prominent guest stars. Pan-assay interference (PAINS) properties to avoid include covalent reactivity, redox activity, and colloidal aggregation.J. D. Rudolf, X. Yan and B. Shen, J. Ind. Microbiol. Biotechnol., 2016, 43, 261–276 CrossRef CAS PubMed. D. Hoffmeister, K. Ichinose, S. Domann, B. Faust, A. Trefzer, G. Drage, A. Kirschning, C. Fischer, E. Kunzel, D. W. Bearden, J. Rohr and A. Bechthold, Chem. Biol., 2000, 7, 821–831 CrossRef CAS PubMed. The brilliant but mentally unstable inventor of a device capable of remotely overloading and destroying any active electrical or electronic circuit is attempting to destroy Probe Control.

Physicochemical properties include stability, solubility, membrane permeability, and a characterized, reproducible structure…. Fig. 2 HPLC analysis of HaiO2-catalyzed reactions. (i) authentic 2, (ii) authentic 3, (iii) authentic 4, (iv) HaiO2 incubated with 3 and NADPH, (v) boiled HaiO2 incubated with 3 and NADPH, (vi) HaiO2 incubated with 2 and NADPH, and (vii) boiled HaiO2 incubated with 2 and NADPH.

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This usage of chemical probes, while consistent with recent drug discovery terminology, should not be confused with probes used in genomics research—DNA or RNA sequences labeled with fluorescent or radioactive tags that can be used to search for their complementary sequences in a sample genome. Probe agents report to V.C.R. Cameron ( Burgess Meredith), the director of the investigations, who runs Probe Control, a center reminiscent of the NASA Mission Control Center. "Cam" is the leader of the expert team who monitors and provides the agent with intelligence.

M. Hatsu, T. Sasaki, H. Watabe, S. Miyadoh, M. Nagasawa, T. Shomura, M. Sezaki, S. Inouye and S. Kondo, J. Antibiot., 1992, 45, 320–324 CrossRef CAS PubMed.G. G. Zhanel, K. Homenuik, K. Nichol, A. Noreddin, L. Vercaigne, J. Embil, A. Gin, J. A. Karlowsky and D. J. Hoban, Drugs, 2004, 64, 63–88 CrossRef CAS PubMed. Introduction Tetracyclines are a class of bacterial aromatic polyketides featuring linearly fused tetracyclic structures and an oxidized 2-naphthacenecarboxamide framework. 1 Tetracyclines target the 30S prokaryotic ribosomal subunit, thus preventing the interaction of aminoacyl-tRNA with the ribosome resulting in the inhibition of translation. 2 This family of antibiotics has been widely used clinically as broad-spectrum antibiotics against Gram-positive and Gram-negative pathogens. 3 As a result, the widespread use of tetracyclines has been hindered by the emergence of resistance. 3–5 Aiming to combat resistant strains, first-generation natural tetracycline antibiotics (chlorotetracycline and oxytetracycline) have been synthetically evolved into second and third-generation tetracyclines. 6,7 Notably, tigecycline, a third-generation tetracycline obtained after glycine modification of the C9 position of the tetracyclic core, can effectively escape from efflux pumps and the ribosome resistance protection mechanism and has become a last line of defence against multi-drug resistant bacteria. 8 Grover is assigned to investigate the disappearance of an exiled revolutionary from a third-world country: kidnapped, assassinated, or planning a coup? And how do a retired general and his chauffeur fit in? Grover, assisted by gossip columnist Kate Dawes (Barbara Feldon), is sent to verify the continued existence of a reclusive billionaire industrialist. Grover's given names is established, along with the reason he goes by initials.