Determine nicotinamide mononucleotide (NMN) is not excluded from the definition of a dietary supplement under 21 U.S.C. §321(ff)(3)(B);

Caution: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your health care provider before using this product.Adding even more to our credibility, the Uthever Scientific Quality Standard Setting Team is under the direction of a former (USP) scientist who ensures that Uthever® NMN Pro capsules are in strict accordance with USP quality standards. NMN Pro Powder allows NMN to be absorbed directly into the blood vessels in the mouth and under the tongue, which increases the product's bioavailability. In this way, NMN avoids digestion in the gastrointestinal tract and can be more rapidly delivered into the bloodstream. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442- Because we are on the front line, we knew the spike in the number of retail suppliers and products wasn't logical. We wanted to protect ourselves and others from what was going on. Our first step was to shore up the integrity of our supply chain and formalise our relationship with Effepharm, manufacturers of Uthever, the only soon-to-be GRAS NMN.

Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K., & Nakagawa, T. (2021). Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Frontiers in Nutrition, 9. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation The proprietary blend in NAD+ Platinum contains TMG, quercetin, and resveratrol. Considering the fact that Gold contains 50mg of TMG, the 60mg dose within this proprietary blend either reduces the amount of TMG to make room for the other ingredients or provides pretty low doses of those added ingredients (even for a sublingual liquid). Don’t be fooled by copycats. Our Uthever® NMN Pro capsules stand out as a brand you can trust with high-quality products containing purity and potency.Reducing obesity:You’re more likely to gain weight as you get older and as your metabolism slows. Because obese people have lower levels of NAD+, replenishing it with NMN supplements may help reverse this and support a healthy body weight. Maintaining a healthy weight can also help reduce your risk of obesity-related illnesses. Supports Healthy Cognition: Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7) One promising ingredient in NAD+ Gold is trimethylglycine (TMG). This ingredient is known as a methyl donor, meaning that it can provide the carbon and hydrogen necessary for methylation. NAD activity and methylation are interdependent processes that the presence of TMG can improve. 18 NAD+ Gold contains 50mg each of NMN and TMG. Be Aware of Fake NMN: Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product. Supplement Facts Suggested Use: Take 1 scoop daily with food continuing fat or fish oil or under the tongue or dissolved in water, preferably in the morning or as directed by your healthcare practitioner.

The basis of the MIB626 drug patent is that it's a novel improvement over naturally occurring NMN, and if it's different and better than NMN then it's not NMN. The drug application should only cover that specific, highly-improved crystal polymorph form of NMN, not all NMN. Currently, we're working with the largest supplement industry groups to ask the government to reconsider their decision. Although I'm sure it will likely take a long time, I hope that eventually NMN is classified as a supplement and MIB626 as a drug. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192From our perspective, taking NMN bulk powder has very little to no side effects as well as no safety concerns. A: We don’t know much about the investigational drug version of NMN. Natural NMN found in food is unstable and occurs in such small quantities that it would be impossible to sell an extract made of natural, unrefined NMN. We know that all supplement and drug forms of NMN are manufactured, refined, stabilized, etc… but we don’t know the differences. NMN and trans-resveratrol work synergistically, which is why longevity experts recommend taking them together for the greatest effectiveness. This dynamic duo has been likened to the operation of a car, with NMN as the fuel and trans-resveratrol as the accelerator pedal. NMN is a natural metabolite of vitamin B3 and a precursor to NAD+ which supports myriad functions essential to health and healthy aging. NAD+ levels decline in human tissue by at least 50 percent between the ages of 40 and 60. Taking NMN boosts natural NAD+ production, and provides the body with energy for gene repair and stimulation. During a meeting on Friday, Dan Fabricant, the head of the Natural Products Association (the NPA) explained that although everyone hopes the citizen's petition leads to an FDA policy reversal on NMN, the filing is meaningful regardless of the FDA's response because it will ultimately allow the trade organizations the right to sue the FDA. Now that the citizen's petition has been filed the FDA has 180 days to respond. Often, they don't respond to citizen's petitions, but in both the case of a denial of the petition or a non-response the NPA and ANH gain the legal right to sue.

Age is the number one risk factor for many illnesses. Researchers are making progress in understanding and treating each of these ailments, in their understanding of the aging process itself, and in how people can help slow the aging process for better overall health. TMG is a methyl donor that complements NMN supplementation by helping replenish the body's methyl pool. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.04.060 NMN supplements haven’t consistently shown any adverse effects in the research. 8 That includes analysis using doses higher than those commonly available. So you can expect to feel only positives as you take NMN. It’s worth noting that there’s no exact way to calculate the absorption rate of one delivery method over another for every possible substance. Even the molecular differences among NMN brands are enough to make a 1:1 comparison meaningless.

Helps combat aging, improves heart health and promotes muscle strength

Li, D., Tian, Y. J., Guo, J., Sun, W. P., Lun, Y. Z., Guo, M., Luo, N., Cao, Y., Cao, J. M., Gong, X. J., & Zhou, S. S. (2013). Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats. The British Journal of Nutrition, 110(12), 2156–2164. Many studies have been performed using NMN bulk supplements to see how much a human could consume before experiencing any side effects. One clinical trial in Japan showed that up to 500mg is safe and capable of providing the most benefit. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985 Supplement Facts