Instances of abnormal hepatic function with elevated hepatic enzymes accompanied by elevated bilirubin have been reported. Mostly this resolves upon discontinuation of the treatment with cetirizine dihydrochloride. Cetirizine does not undergo extensive first pass metabolism. About two third of the dose are excreted unchanged in urine. The terminal half-life is approximately 10 hours. Patients intending to drive, engaging in potentially hazardous activities or operating machinery should not exceed the recommended dose and should take their response to the medicinal product into account. At therapeutic doses, no clinically significant interactions have been demonstrated with alcohol (for a blood alcohol level of 0.5g/L). Nevertheless, precaution is recommended if alcohol is taken concomitantly. Undesirable effects are described according to MedDRA System Organ Class and by estimated frequency based on post-marketing experience.

Galpharm One-a-day Allergy And Hayfever Relief 10mg Tablets Galpharm One-a-day Allergy And Hayfever Relief 10mg Tablets

The Piriton that its active substance is chlorphenamine maleate is a very reliable medicine that is intended for people, although many veterinarians use it regularly. Do not exceed the stated dose when taking Galpharm Hay fever and Allergy Relief Cetirizine Hydrochloride. If symptoms persist whilst taking this medication, consult your doctor.

Side Effects

These tablets should always be kept out of sight and reach of children. Will taking Galpharm Cetirizine and Hydrochloride tablets make you drowsy?

Hayfever Tablets For Dogs | Piriton | Antihistamines Hayfever Tablets For Dogs | Piriton | Antihistamines

Hepatically impaired patients: Patients with chronic liver diseases (hepatocellular, cholestatic, and biliary cirrhosis) given 10 or 20 mg of cetirizine as a single dose had a 50 % increase in half-life along with a 40 % decrease in clearance compared to healthy subjects. In addition to the adverse reactions reported during clinical studies and listed above, the following undesirable effects have been reported in post-marketing experience. The steady – state peak plasma concentrations is approximately 300 ng/ml and is achieved within 1.0 ± 0.5 h. No accumulation is observed for cetirizine following daily doses of 10 mg for 10 days. Objective measurements of driving ability, sleep latency and assembly line performance have not demonstrated any clinically relevant effects at the recommended dose of 10mg.History of hypersensitivity to any of the constituents of the formulation, to hydroxyzine or to any piperazine derivatives. Very common (>1/10); common (>1/100 to <1/10); uncommon (>1/1,000 to 1/100); rare (> 1/10,000 to 1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data)

Galpharm One-a-Day STORING THE MEDICINE Allergy and Hayfever Galpharm One-a-Day STORING THE MEDICINE Allergy and Hayfever

Patients with hepatic impairment: no dose adjustment is needed in patients with solely hepatic impairment. Studies in healthy volunteers show that cetirizine, at doses of 5 and 10 mg strongly inhibits the wheal and flare reactions induced by very high concentrations of histamine into the skin, but the correlation with efficacy is not established. Although statistically more common than under placebo, somnolence was mild to moderate in the majority of cases. Objective tests as demonstrated by other studies have demonstrated that usual daily activities are unaffected at the recommended daily dose in healthy young volunteers. Galpharm antihistamine tablets provide relief from the symptoms of hay fever and other airborne allergies. Galpharm Hay fever and Allergy Relief tablets can also be taken for skin allergies such as rash, itching, and urticaria (hives). The active ingredient in Galpharm antihistamine is Cetirizine, which is known as a non-drowsy antihistamine. It's much less likely to make you feel sleepy than some other antihistamines. In addition to its anti-H1 effect, cetirizine was shown to display anti-allergic activities: at a dose of 10 mg once or twice daily, it inhibits the late phase recruitment of eosinophils, in the skin and conjunctiva of atopic subjects submitted to allergen challenge.Cetirizine is excreted in human milk at concentrations representing 25% to 90% of those measured in plasma, depending on sampling time after administration. Therefore, caution should be exercised when prescribing cetirizine to lactating women. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take cetirizine film-coated tablet. Caution should be taken in patients with predisposition factors of urinary retention (e.g. spinal cord lesion, prostatic hyperplasia) as cetirizine may increase the risk of urinary retention.