After 6 months, chondroitin sulfate led to similar pain scores as celecoxib and significantly lower scores than the placebo. Thus, the authors concluded that chondroitin sulfate may be an effective pain remedy for those with knee osteoarthritis pain ( 10). The first phase of GAIT, published in 2006,found that the combination of glucosamine and chondroitin sulfatedidn’t offer significant relief to participants in general, but it did help a smallsubgroup ofthosewith moderate-to-severe knee pain.Infollow-upresults of the study released in 2010, these supplements improved pain and function, although no better than a placebo or the NSAID drug celecoxib. Holland & Barrett Extra Strength Glucosamine Chondroitin Complex Tablets contribute towards the maintenance of normal bone health and the normal formation of connective tissue. In many European countries, these supplements area prescribedtreatment for OA. In the U.S.,the recommendations on glucosamine and chondroitin are moremoderate,due tothe mixed results of studies.

Since the GAIT trial came out, a few large studies have shown more positive results, saysD’Adamo. “If you look at the totality of the evidence for glucosamine and chondroitin for osteoarthritis of the knee, it’s very strong.”With upward of 3.6% of the global population living with this debilitating condition, many people use or have tried using combined glucosamine and chondroitin supplements to alleviate osteoarthritis pain ( 2). Summary A 2017 double-blind, randomized study in 604 participants with knee osteoarthritis compared the effects of taking 800 mg/day of chondroitin sulfate, 200 mg/day of a popular NSAID known as celecoxib, and a placebo on osteoarthritis pain management ( 10). On the other hand, a 2018 analysis showed small improvements in knee osteoarthritis pain with regular use of glucosamine sulfate, though the authors suggested that higher-quality data is needed ( 7). Glucosamine and chondroitin supplements are controversial, since many experts don’t agree on their effectiveness.

Chondroitin is a naturally occurring substance formed of sugar chains. Chondroitin is believed to help the body maintain fluid and flexibility in the joints.It’s also worth noting that glucosamine supplements can be made from shellfish shells. If you are allergic to shellfish, you might want to look for synthetic glucosamine or choose an option derived from a different source. 15 Glucosamine dosage Glucosamine Sulphate (2KCl) ( Crustaceans), Chondroitin Sulphate, Bulking Agent (Microcrystalline Cellulose), Glazing Agents (Hydroxypropyl Methylcellulose, Glycerol), Vitamin C (L-Ascorbic Acid), Citrus Bioflavonoids Complex, Anti-Caking Agents (Magnesium Stearate, Silicon Dioxide), Manganese Sulphate. While MSM is found in many foods -- including meat, fish, certain fruit, vegetables, and grains -- it is destroyed when foods are processed. MSM supplements have become increasingly popular in recent years and many people feel they have had some pain relief since taking MSM. Although some studies have reported improvement in pain with MSM, more research needs to be done to support its use as an arthritis supplement. MSM is a naturally occurring compound and its effects on inflammation have been extensively studied.