Devil's Claw Gel 98% Extra Strong, 500 ml, Made in Italy for Massage to Joints and Muscles, Natural Formula and Dermatologically Tested on Sensitive Skin - Dulàc Pharma

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This review reported five RCTs dating from 1980 into the use of devil’s claw for osteoarthritis of the hip or the knee.

Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., and Tenborg, M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern.Med.Rev. 2006;11:128-150. View abstract.

Diaz-Silveira GL, Deutsch J, Little DP. DNA Barcode Authentication of Devil's Claw Herbal Dietary Supplements. Plants (Basel) 2021;10(10):2005. View abstract. Teut, M. and Warning, A. [Bone metastases in breast carcinoma]. Forsch Komplement.Med (2006.) 2006;13(1):46-48. View abstract. Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72. View abstract. Occhiuto, F., Circosta, C., Ragusa, S., Ficarra, P., and Costa, De Pasquale. A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. J Ethnopharmacol. 1985;13:201-208. View abstract. Some products contain devil’s claw, but typical dosage used in studies consists of 750mg three times a day. Does devil’s claw really work?

Chrubasik S and Eisenberg E. Treatment of rheumatic pain with Kampo medicine in Europe. The Pain Clinic 1999;11(3):171.Eichler, O. and Koch, C. [Antiphlogistic, analgesic and spasmolytic effect of harpagoside, a glycoside from the root of Harpagophytum procumbens DC]. Arzneimittelforschung. 1970;20:107-109. View abstract. Brien, S., Lewith, G. T., and McGregor, G. Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 2006;12(10):981-993. View abstract.

In particular, devil’s claw contains iridoid glycosides, a class of compounds which has demonstrated anti-inflammatory effects ( 2). Stomach acid reducers: Devil’s claw may decrease the effects of stomach acid reducers, such as Pepcid, Prilosec and Prevacid. Occhiuto, F., Circosta, C., Ragusa, S., Ficarra, P., and Costa, De Pasquale. A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. J Ethnopharmacol. 1985;13(2):201-208. View abstract.Devil’s claw is often available as an ingredient within a product aimed at reducing muscle pain or arthritis-related symptoms. Some brands also provide devil’s claw on its own, 600mg of devil’s claw extract. You can find it in healthfood stores or online. How long does devil’s claw take to work? Though devil’s claw has not been studied extensively in humans, preliminary evidence suggests that it may be an alternative treatment for inflammatory conditions. Summary Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. View abstract. Baghdikian, B., Guiraud-Dauriac, H., Ollivier, E., N'Guyen, A., Dumenil, G., and Balansard, G. Formation of nitrogen-containing metabolites from the main iridoids of Harpagophytum procumbens and H. zeyheri by human intestinal bacteria. Planta Med 1999;65(2):164-166. View abstract.

Tunmann P and Bauersfeld HJ. Über weitere Inhaltsstoffe der Wurzel von Harpagophytum procumbens DC. Arch Pharm (Weinheim) 1975;308:655-657. Kundu, J. K., Mossanda, K. S., Na, H. K., and Surh, Y. J. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Cancer Lett. 1-31-2005;218(1):21-31. View abstract. It is important to stay as active as possible and to keep up your daily activities. Resting for long periods can actually make the pain worse. Some common proton pump inhibitors include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium). Three studies (two of which were considered to be of high quality) compared devil’s claw with a placebo. Participants who were given devil’s claw had a significant improvement in osteoarthritis-related pain compared to those who were on a placebo.

How much devil’s claw is safe to take?

Inflammation is your body’s natural response to injury and infection. When you cut your finger, bang your knee or come down with the flu, your body responds by activating your immune system ( 6).