Joined in 2023 
82 
63 About this deal
Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. (2023-Jan-26) Because many of our customers are trying to conceive, or plan to in the future, we want to ensure that we offer the most effective solution. Combining Preconception with Myoplus Milewska EM, Czyzyk A, Meczekalski B, Genazzani AD. Inositol and human reproduction. From cellular metabolism to clinical use. Gynecol Endocrinol. 2016;32(9):690–5.
Fertility - Papaleo E, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis L Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial Fertil Steril. (2009 May) Based on consumer taking 4 tablets of the preconception formula per day (providing 2,000mg myo-inositol) and 2 tablets of MyoPlus per day (providing 2,000mg myo-inositol) What’s inside (and why) Inositols have long been debated as a potential alternative for metformin in treating PCOS. Therefore, the present systematic review aimed to evaluate the efficacy and safety of inositols in treating PCOS. Methods
Mashayekh-Amiri S, Mohammad-Alizadeh-Charandabi S, Abdolalipour S, Mirghafourvand M Myo-inositol supplementation for prevention of gestational diabetes mellitus in overweight and obese pregnant women: a systematic review and meta-analysis. Diabetol Metab Syndr. (2022-Jul-06) Two independent review authors selected the articles via the EndNote X9 (Clarivate Analytics, Philadelphia, PA, USA) reference manager program. Publications were screened based on title, and abstract first, and then the full text based on the eligibility criteria. A third independent review author resolved disagreements during the selection process. Data collection process and data items Papaleo E, Unfer V et al. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecol Endocrinol. 2007 Dec;23(12):700-3. Epub 2007 Oct 10. Inositol shows promise for the management of polycystic ovary syndrome (PCOS), [13] [14] [15] a condition characterized by high androgen levels, infertility, and abnormalities in glucose metabolism in women. However, given the small number of studies, the small sample sizes of these studies, and the general low quality of the evidence, further research is needed before firm conclusions can be made. Costantino D, Minozzi G, Minozzi F, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: A double-blind trial. Eur Rev Med Pharmacol Sci. 2009;13(2):105–10.
A number of recent studies have found myo-inositol to be an effective support in PCOS, in part due to its ability to improve insulin sensitivity, restore hormonal balance, improve menstrual regularity, reduce hyperandrogenism and influence ovarian function. Research has also demonstrated fertility-improving effects of myo-inositol among women with PCOS; and since the syndrome is the leading cause of female infertility, these results are particularly encouraging. 13-22 The limitations of this analysis were the small number of studies with small sample size, and the heterogeneous populations. Furthermore, the follow-up time differed among the studies. In addition, studies investigated different dosages of inositols in inositol monotherapy compared to inositol combinations. The generalization of pregnancy rate results was problematic since only one study analyzed women who wanted pregnancy. In addition, graphs of AUC-insulin and glucose were missing. Therefore, interpreting these results was complicated to judge the effect of inositols and metformin on early and late insulin responses. Lastly, the presence of moderate and high risk of bias in some domains was another limitation. Implications for practice and research
Pundir J, Psaroudakis D, Savnur P, Bhide P, Sabatini L, Teede H, et al. Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. BJOG. 2018;125(3):299–308. The continuous results were presented by calculating mean differences (MD) with 95% confidence intervals (CIs) for continuous variables from the changes between the baseline and after treatment value. Because of missing correlation of before and after values, a 0 correlation was assumed to calculate the SD of change. In the case of missing SD and presence of p-value, the recommendation of Cochrane handbook was followed [ 24] To pool MDs, the random-effects model was applied with inverse variance method, and Restricted maximum-likelihood method was used to estimate variance measure τ 2 [ 25]. In the case of dichotomous categorical outcomes, pooled risk ratios (RRs) were calculated with 95% CIs using the random-effects model with the Mantel–Haenszel method, and to obtain τ 2 the Paule-Mandel estimator was used [ 26]. Provides a wide spectrum of 16 vitamins and minerals plus 2000mg Myo-inositol to support your overall health as well as your fertility journey, when taken alongside a healthy, balanced diet. Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):555-61.
19. Papaleo E, Unfer V, et al. Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil Steril. 2009 May;91(5):1750-4.
Fulghesu AM, Romualdi D, Di Florio C, Sanna S, Tagliaferri V, Gambineri A, et al. Is there a dose-response relationship of metformin treatment in patients with polycystic ovary syndrome? Results from a multicentric study. Hum Reprod. 2012;27(10):3057–66. Myo-inositol is one supplement in particular which has received widespread attention for the potential role it has to play in supporting women with PCOS. And much research to date indicates that this novel supplement has the potential to provide support for many of these key areas. Insulin resistance, a problem with your body’s ability to respond to insulin, is considered one of the key factors associated with conditions like metabolic syndrome ( 8).Pourghasem S, Bazarganipour F, Taghavi SA, Kutenaee MA. The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole. Arch Gynecol Obstet. 2019;299(4):1193–9.
Berridge MJ The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease. Physiol Rev. (2016-Oct)
Commonly asked questions about Inositol Plus:
Zarezadeh M, Dehghani A, Faghfouri AH, Radkhah N, Naemi Kermanshahi M, Hamedi Kalajahi F, Mohammadzadeh Honarvar N, Ghoreishi Z, Ostadrahimi A, Ebrahimi Mamaghani M Inositol supplementation and body mass index: A systematic review and meta-analysis of randomized clinical trials. Obes Sci Pract. (2022-Jun)
Related:
Great Deal 
New Comment