Health4All Vitamin K2 MK7 200mcg 90 Tablets (V) Natural Vegan MK7 from Natto Beans Fermentation. High Strength k2mk7 Tablets (not Capsules) K2 Vitamin Supplements. VIT K2 mk7

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Biological effects of fermentation derived MK-7 (90µg) and 3 doses of synthetic MK-7 (45, 90, and 180µg) were compared in a randomized double-blinded parallel study. Placebo, 45µg synthetic MK-7, 90µg synthetic MK-7, 180µg synthetic MK-7 or 90µg fermentation-derived MK-7 were administered daily to the subjects for 43days. Blood samples were collected for measurement of MK-7 as well as serum concentrations of cOC and ucOC. There was an increase in serum cOC concentration and a reduction in serum ucOC concentration after daily intake of the highest dose of synthetic MK-7 (180µg) for 6weeks. The fermentation-derived MK-7 group showed similar results. Therefore, it was concluded that the tested synthetic form of MK-7 is bioequivalent to fermentation-derived MK-7, exhibits vitamin K activity and can be well tolerated in healthy subjects ( Møller et al., 2017). The same is true of vitamin K. K vitamins are fat-soluble, meaning they dissolve in fats and oils. And they play important roles in blood clotting, bone health and heart health.

Coagulation factors ( II, VII, IX, X), as well as anticoagulation proteins ( C, S, Z). These Gla-proteins are synthesized in the liver and play an important role in blood homeostasis. One study found that people who took in at least 32 micrograms per day of vitamin K2 in their diet were 50% less likely to die from heart disease related to hardened arteries. People in that study didn’t consume any vitamin K1. a b c d Myneni VD, Mezey E (November 2017). "Regulation of bone remodeling by vitamin K2". Oral Diseases. 23 (8): 1021–1028. doi: 10.1111/odi.12624. PMC 5471136. PMID 27976475. Hadipour et al. ( Hadipour et al., 2020) studied the effects of vitamin K2 at concentrations ranging from 5 to 200μM in rat pheochromocytoma PC-12 cells to provide protection against toxicity caused by hydrogen peroxide and β-amyloid. Vitamin K2 reduced the cytotoxicity caused by hydrogen peroxide and β-amyloid. In Alzheimer’s disease, β-amyloid led to neuronal death by direct toxicity and by promotion of apoptosis; whereas vitamin K2 prevented neuronal death resulting from β-amyloid in PC-12 cells. The cells that were pre-treated with vitamin K2 exhibited remarkably less apoptosis when the cells were exposed to either hydrogen peroxide or β-amyloid. Further, vitamin K2 also decreased the levels of reactive oxygen species (ROS) in PC-12 cells that were exposed to hydrogen peroxide and β-amyloid. The levels of glutathione, an antioxidant, also increased when cells were pre-treated with 20 and 50μM of vitamin K2. Hence, vitamin K2 pre-treatment reduced apoptosis signaling proteins (β-amyloid, caspase 3, etc.), attenuated levels of ROS, and increased levels of glutathione. In addition, it was reported that PC-12 cells when treated with hydrogen peroxide and β-amyloid increased phospho-p38 MAP kinase, PARP cleavage and Bax/Bcl-2 ratio; while pre-treatment with vitamin K2 resulted in decreased phosphorylation of p38 MAPK, PARP cleavage and mRNA level of Bax/Bcl-2. Inactivation of p38 MAPK pathway was identified as a mechanism for potential protective role of vitamin K2 in AD. Hence, the study confirms the protective role of vitamin K2 mediated by its antioxidant and anti-apoptotic properties ( Hadipour et al., 2020). SN conceived of the manuscript. DM and SN edited the manuscript. NJ, SA, PS, PG, AP, VB, YG, SP, and SJ wrote the manuscript and prepared the tables and figures under the supervision of SN. All authors read and approved the manuscript. FundingIn Japan and other parts of Asia, one kind of vitamin K2 (MK-4), is used as a treatment for osteoporosis. Improves heart health A randomized controlled trial was conducted by Sakak et al. ( Rahimi Sakak et al., 2021) on 68 patients with type 2 diabetes on oral glucose-lowering therapy. Patients were either administered 360μg of MK-7 or placebo daily for 12weeks. No significant difference in the atherogenic status between the MK-7 or placebo group was observed. Hence, it was concluded that 360μg of MK-7 supplementation for 12weeks cannot improve the insulin resistant (IR)-related indexes of cardiovascular risk ( Rahimi Sakak et al., 2021). Also, a randomized, double-blind placebo-controlled trial was performed to assess whether the supplementation of menaquinone-7 decreases vascular calcification in patients having type 2 diabetes and cardiovascular disease (CVD). Sixty-eight patients were randomly administered either with 360μg daily of MK-7 or placebo for 6months. Blood samples of the patients administered with MK-7 showed increased active calcification compared with placebo when measured with 18sodium fluoride positron emission tomography ( 18F-Na PET) activity; however, no effect was found in calcification mass on conventional computed tomography (CT) ( Zwakenberg et al., 2019). Vitamin K2 is mainly found in certain animal and fermented foods, which most people don’t eat much of.

Some early studies are showing that vitamin K2 supplements may reduce fractures and improve bone quality in people with osteoporosis.Hawkins D, Evans J (May 2005). "Minimising the risk of heparin-induced osteoporosis during pregnancy". Expert Opinion on Drug Safety. 4 (3): 583–90. doi: 10.1517/14740338.4.3.583. PMID 15934862. S2CID 32013673. Osteocalcin. This non-collagenous protein is secreted by osteoblasts and plays an essential role in the formation of mineral in bone. Gut bacteria in your large intestine also produce vitamin K2. Some evidence suggests that broad-spectrum antibiotics contribute to K2 deficiency ( 22). Vitamin K is absorbed along with dietary fat from the small intestine and transported by chylomicrons in the circulation. [11] Most of vitamin K 1 is carried by triacylglycerol-rich lipoproteins (TRL) and rapidly cleared by the liver; only a small amount is released into the circulation and carried by LDL and HDL. MK-4 is carried by the same lipoproteins (TRL, LDL, and HDL) and cleared fast as well. The long-chain menaquinones are absorbed in the same way as vitamin K 1 and MK-4, but are efficiently redistributed by the liver in predominantly LDL (VLDL). Since LDL has a long half life in the circulation, these menaquinones can circulate for extended times resulting in higher bioavailability for extra-hepatic tissues as compared to vitamin K 1 and MK-4. Accumulation of vitamin K in extra-hepatic tissues has direct relevance to vitamin K functions not related to hemostasis. [12] Dietary intake in humans [ edit ] Apart from animal livers, the richest dietary source of menaquinones are fermented foods (from bacteria, not molds or yeasts); sources include cheeses consumed in Western diets (e.g., containing MK-8 and MK-9) and fermented soybean products (e.g., in traditional nattō consumed in Japan, containing MK-7). [ citation needed] (Here and following it is noteworthy that most food assays measure only fully unsaturated menaquinones. [ citation needed])