Cold Sore Treatment - 2g Cream - 5% w/w (2 x Lipsore Cream)

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Advise patients to apply the cream to the lesion as near as possible to the start of infection. Treat recurrent episodes during the prodromal period or when lesions first appear. Aciclovir is an antiviral cream used to treat herpes simplex. Herpes simplex virus or HSV for short is a highly contagious virus that once contracted, usually before the age of 10, lies inactive within the body. HSV can then become active from time to time, usually if you are run down. HSV is very common it is believed that 7 in 10 people carry the virus but for some people it might remain inactive.

Talk to your doctor or pharmacist before using Lipsore cream ifyou are pregnant, trying to become pregnant or are breast-feeding. Use of the cream should be considered only when the potential benefit outweighs the possibility of unknown risks however the systemic exposure to aciclovir from topical application of aciclovir cream is very low.Start using the cream at the first sign of infection (for instance, when you first feel your skin tingling) and continue to use it for five days. This is often sufficient time for the sore to heal but you can continue to use the cream for a further five days if needed. Remember to wash and dry your hands before and after using aciclovir, to prevent spreading any infection. Paediatric Formulary Committee. BNF for Children 2015-2016. London: BMJ Group, Pharmaceutical Press, and RCPCH Publications; 2015. Largely reversible adverse effects on spermatogenesis in association with overall toxicity in rats and dogs have been reported only at doses greatly in excess of those employed therapeutically. Two generation studies in mice did not reveal any effect of orally administered aciclovir on fertility. Here, we look at some common questions about cold sore creams. Do cold sore creams work for canker sores?

Use the cream for up to 5 days. If the infection has not healed after this time, you can continue to use it for a further 5 days. Dose adjustment of IV for patients with acute or chronic renal impairment, based on Creatinine Clearance, Cr Cl (mL/min/1.73 m2): In a non-standard test in rats, foetal abnormalities were observed, but only following such high subcutaneous doses that maternal toxicity was produced. The clinical relevance of these findings is uncertain. Summary of Product Characteristics: Zovirax Cold Sore cream. GlaxoSmithKline Consumer Healthcare. Revised March 2014. In internationally accepted standard tests the systemic administration of Aciclovir did not produce embryotoxic or teratogenic effects in rabbits, rats or mice.A post-marketing aciclovir pregnancy registry has documented pregnancy outcomes in women exposed to any formulation of aciclovir. The birth defects described amongst aciclovir exposed subjects have not shown any uniqueness or consistent pattern to suggest a common cause. Karlsmark, T., et al. (2008). Randomized clinical study comparing compeed cold sore patch to acyclovir cream 5% in the treatment of herpes simplex labialis [Abstract]. Two metabolites could be identified in the urine of patients with normal renal function after single dosing with 14C-Aciclovir: 9-carboxymethoxymethylguanine (2-14% of an administered dose) and 8-hydroxy-9-(2-hydroxyethoxymethyl)guanine(<0.2% of a dose). Subjects with normal renal function eliminate 62-91% of an aciclovir dose unchanged and 9-14% as 9-carboxymethoxymethylguanine via the kidneys. Not recommended for use by patients who know they are immunocompromised e.g. by HIV infection, bone marrow transplant or cancer treatment, except on the advice of a doctor. Such individuals should be encouraged to consult a physician concerning the treatment of an infection.