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A positive Hoffman sign indicates an upper motor neuron lesion and corticospinal pathway dysfunction likely due to cervical cord compression. What causes positive Hoffman’s? On the other hand, we found that the 3-min contraction at 10% MVC produced muscle fatigue, part of which had a peripheral component, as evidenced by the decrease in the resting twitch, and part of which was due to central mechanisms, as suggested by the disproportionate increase in participants’ perceived effort compared to the increase in EMG RMS. The present study investigated possible changes in sarcolemmal excitability during a 3-min contraction of the knee extensors sustained at 10% MVC. The main findings were: (1) Both maximal voluntary force and resting peak twitch force decreased after the low-force contraction; (2) Conduction velocity remained unchanged during the sustained contraction; (3) The amplitude of the M-wave first phase decreased for the first ~30s, and stabilized thereafter, whereas the second phase amplitude increased for the initial ~30s, before stabilizing; and (4) Both duration and area decreased steeply during the first ~30s, and then more gradually for the rest of the contraction. Muscle Fatigue Induced by the Prolonged Contraction: Central and Peripheral Mechanisms

Thesleff S (1959) Motor end-plate ‘desensitization’ by repetitive nerve stimuli. J Physiol 148:659–664 Unlike the amplitude parameters, Dur FIRST (plot d) and Dur SECOND (plot e) behaved in a similar manner during the contraction: both parameters decreased rapidly and significantly during the initial ~30s ( p<0.05), and subsequently continued decreasing more gradually for the remainder of the contraction. The time course of changes in Dur PP followed the same trend as that of Dur FIRST and Dur SECOND. Although not shown in Figure 4, the changes in Area FIRST and Area SECOND were in all aspects similar to those in Dur FIRST and Dur SECOND, respectively. Changes in the M-Wave Parameters During Recovery Rodriguez-Falces J, Duchateau J, Muraoka Y, Baudry S (2015b) M-wave potentiation after voluntary contractions of different durations and intensities in the tibialis anterior. J Appl Physiol (1985) 118(8):953–964. https://doi.org/10.1152/japplphysiol.01144.2014 McGill KC, Lateva ZC, Xiao S (2001) A model of the muscle action potential for describing the leading edge, terminal wave, and slow afterwave. IEEE Trans Biomed Eng 48(12):1357–1365. https://doi.org/10.1109/10.966595 Plaskett CJ, Cafarelli E (2001) Caffeine increases endurance and attenuates force sensation during submaximal isometric contractions. J Appl Physiol (1985) 91(4):1535–1544

What is an M wave in physiology?

Knight CA, Kamen G (2005) Superficial motor units are larger than deeper motor units in human vastus lateralis muscle. Muscle Nerve 31(4):475–480. https://doi.org/10.1002/mus.20265 Everts ME, Retterstol K, Clausen T (1988) Effects of adrenaline on excitation-induced stimulation of the sodium-potassium pump in rat skeletal muscle. Acta Physiol Scand 134(2):189–198. https://doi.org/10.1111/j.1748-1716.1988.tb08479.x

Rodriguez-Falces J, Place N (2015) Power spectral changes of the superimposed M wave during isometric voluntary contractions of increasing strength. Muscle Nerve 51(4):580–591. https://doi.org/10.1002/mus.24418 Place N, Yamada T, Bruton JD, Westerblad H (2010) Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres. Eur J Appl Physiol 110(1):1–15. https://doi.org/10.1007/s00421-010-1480-0Rodriguez-Falces J, Place N (2017a) New insights into the potentiation of the first and second phases of the M-wave after voluntary contractions in the quadriceps muscle. Muscle Nerve 55(1):35–45. https://doi.org/10.1002/mus.25186

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