A new study has shown that a special compound in pomegranate called urolithin can lead to powerful health benefits – including significant anti-aging support. Find out everything you need to know about Urolithin A and using pomegranate for anti-aging. What is Urolithin? No significant improvements were observed for either urolithin A group compared to placebo for peak power output, said the researchers.

We started with preclinical trials, using tiny little worms called C. elegans, and showed that these worms were living close to 40-45% longer after taking your Urolithin-A compared to placebo. We then took it into mice, and started learning more about the running endurance and muscle health potential benefits. FL: If you think about the mechanism of action here, what we've shown is Urolithin A acts on the mitochondria. Even more specifically, it acts on the mitophagy pathway. In short, mitophagy is a natural cleansing and renewal process whereby damaged and inefficient mitochondria are identified and cleared away. FL: Many researchers around the world are doing interesting studies with Urolithin A. And in the last 10 years alone, if you go to pubmed.org, you'll find over 100, preclinical studies, exploring the benefits of Urolithin A. the effect is nothing short of amazing.” That study describes it as “David against the Goliath of aging.”

Garcia-Villalba R, Vissenaekens H, Pitart J, Romo-Vaquero M, Espin JC, Grootaert C, et al. Gastrointestinal simulation model TWIN-SHIME shows differences between human urolithin-metabotypes in gut microbiota composition, pomegranate polyphenol metabolism, and transport along the intestinal tract. J Agric Food Chem. 2017;65:5480–93. Don’t run out to the supermarket and buy pomegranate right away. The fruit itself doesn’t contain the miracle molecule.

As you look at mitophagy and inducers of mitophagy, exercise is a one, another key one is caloric restriction. Inviting all health, fitness, beauty, and wellness experts from around the world to join Zotezo, the ultimate trust commerce platform, and empower millions to make the right decisions for their wellbeing. Share your knowledge, review the highest quality products, and provide valuable insights to our engaged audience. Together, let's create a healthier, happier world! Instead, as mentioned above, pomegranate contains a precursor to urolithin. When that precursor enters your body and encounters microbes in your intestine, it will get converted into urolithin A. Mitochondria are like batteries that power the cells in your body,” he said. “But over time, they break down. The process of mitophagy recognizes this failure and proactively tears down the mitochondria, reducing it to elemental components that a cell can reuse. But with aging, mitophagy becomes less efficient and your body accumulates this pool of failing mitochondria. It’s one way that muscles become less functional as we age [ 1].”A few interventional studies have investigated the presence of urolithin metabolites after intake of dietary fruits (strawberry and raspberry) and nuts (walnuts) in different study populations [ 11, 12]. Investigators have also examined the association between different urolithin plasma profiles and health benefits, such as lowering cardiovascular risk in overweight populations [ 2, 13, 14]. However, there are limited data in large and diverse age groups in healthy adult populations describing the frequency and extent of people’s natural ability to convert ET and EA into UA such as after drinking a glass of pomegranate juice (PJ) or eating the recommended quantities of nuts and berries. This is an important difference because the amount of urolithin A yo

Conduct third-party testing: This ensures that the product’s label accurately reflects its contents and that it meets quality and safety standards. Verdam FJ, Fuentes S, de Jonge C, Zoetendal EG, Erbil R, Greve JW, et al. Human intestinal microbiota composition is associated with local and systemic inflammation in. Obes Obes (Silver Spring). 2013;21:E607–15. Last but not least, Urolithin A’s antioxidant properties may extend to the skin, where it can help combat the signs of aging, such as wrinkles and fine lines. By protecting skin cells from damage, it contributes to a youthful, radiant complexion. The purpose of this first trial was a couple of things. First and foremost, was to establish safety. So that was the primary endpoint. But what was fascinating and remarkable is we also started looking at the impact of Urolithin A on mitochondrial function, and more specifically on gene expression.Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022–3. This is the first study to compare the levels of exposure to UA obtained via natural dietary exposure to precursors vs. direct dietary supplementation with UA, and to evaluate the prevalence of natural UA producers across a significant sample size of a hundred healthy adults in a major metropolitan area in USA. This study has led to a further understanding of the complexity of obtaining UA from the diet alone due to dietary differences and the diversity of the microbiome among the general population. Prior to this report, there have been several studies of much smaller scope performed in southern Europe that have explored the identities of the urolithin metabolites produced in individuals following dietary challenges of pomegranate, berries, and nuts rich in ET [ 1, 3, 13, 21]. These studies have led to the detailed chemical characterization of the family of urolithin metabolites produced following ellagitannin consumption as well as an appreciation of the natural ability to produce these different urolithins, which was observed to range from 30 to 60%. In the studied cohort, only 12% participants had circulating levels of UA at baseline and ~40% significantly converted the dietary precursors to UA after the PJ dietary challenge (Fig. 2). And while no significant improvements compared to placebo were observed for VO2max, total cycling distance, and results of the 6-minute walking test, statistically significant improvements were observed in the high dose group compared to baseline levels. Specifically, the researchers noted that the cycling distance increased by 15% when compared to levels at the start of the study, while walking distance increased by an average of 33.4 meters.

These potent beneficial effects were observed in different organisms, including C. elegans​, mammalian cells, rodents, and several human clinical trials.An oral supplement intended to stimulate a natural body process appears to promote muscle endurance and mitochondrial health in humans. New research, published in JAMA Network Open, suggests that the supplement, urolithin A, may help improve or prolong muscle activity in people who are aging or who have diseases that make exercise difficult. Subjects were randomized (1:1) to either PJ or a food product containing UA (500 mg). Prevalence of UA producers and non-producers were determined in the PJ group. Diet questionnaires and fecal samples were collected to compare differences between UA producers and non-producers along with plasma samples at different time points to assess levels of UA and its conjugates between the interventions. Results Since then, Nestlé Health Science has gone into partnership with Amazentis to develop off-the-shelf products containing Mitopure, Amazentis’ proprietary urolithin A, which are marketed under the Timeline brand and includes powder and soft-gel forms. Although rare, allergic reactions to Urolithin A supplements can occur. If you have a known allergy to pomegranates, berries, or any foods rich in ellagitannins, exercise caution when using Urolithin A supplements. Look for signs of an allergic reaction, such as itching, hives, swelling, or difficulty breathing, and discontinue use if any of these symptoms occur. 4. Dosage and Timing: