Elipta Rechargeable Battery Outdoor LED Table Lamp - Black or White (White)

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Administration of umeclidinium bromide may produce paradoxical bronchospasm that may be life-threatening. If paradoxical bronchospasm occurs treatment should be discontinued immediately and alternative therapy instituted if necessary. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. If you are not sure what your medicine contains talk to your doctor or pharmacist. ANORO ELLIPTA should not be used in children. It is not known if ANORO ELLIPTA is safe and effective in children.

Raised blood pressure is a possible side effect of Trelegy Ellipta. It’s not known how often this occurred in people taking the drug in studies. This side effect is caused by vilanterol, one of the three active drugs* in Trelegy Ellipta. To lower your risk of thrush, rinse your mouth with water and spit the water out (without swallowing) after each dose of Trelegy Ellipta. Yes, Trelegy Ellipta is used to help manage chronic obstructive pulmonary disease (COPD) symptoms in adults. (It’s also used to help manage asthma symptoms. This use is described below in “ Is Trelegy Ellipta used for asthma?”) ANORO ELLIPTA does not relieve sudden symptoms of COPD and you should not take extra doses of ANORO ELLIPTA to relieve these sudden symptoms. Always have a rescue inhaler with you to treat sudden symptoms. If you do not have a rescue inhaler, call your healthcare provider to have one prescribed for you. In two replicate 12 month studies in a total of 3,255 patients with COPD the incidence of bone fractures overall was low in all treatment groups, with a higher incidence in all Relvar Ellipta groups (2%) compared with the vilanterol 22 micrograms group (<1%). Although there were more fractures in the Relvar Ellipta groups compared with the vilanterol 22 micrograms group, fractures typically associated with corticosteroid use (e.g., spinal compression/thoracolumbar vertebral fractures, hip and acetabular fractures) occurred in <1% of the Relvar Ellipta and vilanterol treatment arms.When you take the inhaler out of its tray, it will be in the ‘closed’ position. Don’t open the inhaler until you are ready to inhale a dose of medicine . When the tray is opened, write the “Discard by” date on the inhaler label in the space provided. The “Discard by” date is 6 weeks from the date you open the tray. After this date the inhaler should no longer be used. The tray can be discarded after first opening. You may have questions about Trelegy Ellipta and your treatment plan. It’s important to discuss all your concerns with your doctor. In a randomised, double-blind, 52-week study (CTT116855, IMPACT) of 10,355 adult patients with symptomatic COPD and a history of 1 or more moderate or severe exacerbations within the prior 1 The bronchoprotective effect of fluticasone furoate/vilanterol 92/22 micrograms on the early and late asthmatic response to inhaled allergen was evaluated in a repeat dose, placebo-controlled four-way crossover study (HZA113126) in patients with mild asthma. Patients were randomized to receive fluticasone furoate/vilanterol 92/22 micrograms, FF 92 micrograms, vilanterol 22 micrograms or placebo once daily for 21 days followed by challenge with allergen 1 hour after the final dose. The allergen was house dust mite, cat dander, or birch pollen; the selection was based on individual screening tests. Serial FEV 1 measurements were compared with pre-allergen challenge values taken after saline inhalation (baseline). Overall, the greatest effects on the early asthmatic response were seen with fluticasone furoate/vilanterol 92/22 micrograms compared with FF 92 micrograms or vilanterol 22 micrograms alone. Both fluticasone furoate/vilanterol 92/22 micrograms and FF 92 micrograms virtually abolished the late asthmatic response compared with vilanterol alone. Fluticasone furoate/vilanterol 92/22 micrograms provided significantly greater protection against allergen-induced bronchial hyper-reactivity compared with monotherapies FF and vilanterol as assessed on Day 22 by methacholine challenge.

Before taking Trelegy Ellipta, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Trelegy Ellipta. Interactions with drugs or supplementsFor patients with moderate to severe hepatic impairment, the 92/22 micrograms dose should be used and patients should be monitored for systemic corticosteroid-related adverse reactions (see section 5.2). medicines that lower the amount of potassium in your blood, such as some diuretics (water tablets) or some medicines used to treat asthma (such as methylxanthine or steroids) Fluticasone furoate/vilanterol should be administered with caution in patients with pulmonary tuberculosis or in patients with chronic or untreated infections.

A randomised, double-blind, parallel group, 24 week study (201378) was conducted to demonstrate non-inferiority (using a margin of -100 mL for trough FEV 1) of fluticasone furoate/vilanterol 92/22 once daily to salmeterol/FP 50/250 twice daily in adults and adolescents whose asthma was well controlled following 4 weeks of treatment with open-label salmeterol/FP 50/250 twice daily (N=1504). Subjects randomised to once-daily FF/VI maintained lung function comparable with those randomised to twice-daily salmeterol/FP [difference in trough FEV 1 of +19 mL (95% CI: -11, 49)].Your doctor will recommend whether you should keep using Trelegy Ellipta if you have thrush. They might have you pause Trelegy Ellipta treatment until the thrush is treated. Raised blood pressure symptoms of using too much of a LABA medicine, including: chest pain; increased blood pressure; fast or irregular heartbeat; headache; tremor; nervousness. Your leaflet has a pictogram in this location showing a hand removing the tray lid from the tray and the desiccant being placed in a waste bin. There is insufficient information on the excretion of fluticasone furoate or vilanterol trifenatate and/or metabolites in human milk. However, other corticosteroids and beta 2-agonists are detected in human milk (see section 5.3). A risk to breastfed newborns/infants cannot be excluded. If you develop high blood pressure while using Trelegy Ellipta, your doctor may prescribe medications to manage this. Sudden trouble breathing

ANORO ELLIPTA is not for the treatment of asthma. It is not known if ANORO ELLIPTA is safe and effective in people with asthma.

If the inhaler cover is opened and closed without inhaling the medicine, the dose will be lost. The lost dose will be securely held inside the inhaler, but it will no longer be available to be inhaled. If your symptoms feel life threatening, call 911 (or your local emergency number) or get immediate medical help. Three phase III randomised, double-blind studies (HZA106827, HZA106829 and HZA106837) of different durations evaluated the safety and efficacy of fluticasone furoate/vilanterol in adult and adolescent patients with persistent asthma. All subjects were using an ICS (Inhaled corticosteroid) with or without LABA for at least 12 weeks prior to visit 1. In HZA106837 all patients had at least one exacerbation that required treatment with oral corticosteroids in the year prior to visit 1. HZA106827 was 12 weeks in duration and evaluated the efficacy of fluticasone furoate/vilanterol 92/22 micrograms [n=201] and FF 92 micrograms [n=205]) compared with placebo [n=203], all administered once daily. HZA106829 was 24 weeks in duration and evaluated the efficacy of fluticasone furoate/vilanterol 184/22 micrograms [n=197] and FF 184 micrograms [n=194]) both administered once daily compared with FP 500 micrograms twice daily [n=195]. Before you start treatment with Trelegy Ellipta, your doctor will evaluate your risk of side effects, including raised blood pressure. Talk with your doctor if you’re concerned about hair loss with any medications you take. Is Trelegy Ellipta similar to alternative drugs, such as Advair and Spiriva?