Essentiale Forte 50 capsules Liver Detox Cleanse Regeneration Health Support - contains Soy Essential Phospholipids Non-GMO

Product Information

Declines in renal function, shown by increased serum creatinine and hypokalaemia, have not typically required discontinuation of treatment. Always take this medicine exactly as described in this leaflet or as directed by your doctor or pharmacist. If in doubt, ask your doctor or pharmacist. The active substance is soy phospholipids. Each capsule contains 300 mg of soybean phospholipids containing 76% 3-sn-phosphatidylcholine. Injection of Essentiale Forte should commence within 6 hours of dilution with 5% Dextrose Injection.

Since conventional Essentiale Forte first became available, there have been no reports of drug-related carcinogenicity, mutagenicity, teratogenicity or adverse effect on fertility. Abelcet has been shown not to be mutagenic by the in vivo mouse micronucleus assay, in vitro bacterial and lymphoma mutation assays, and an in vivo cytogenetic assay. It has been shown not to be teratogenic in mice and rabbits. Directions for Reconstitution, Filtration and Dilution Read This Entire Section Carefully Before Beginning Reconstitution Essentiale Forte must be reconstituted using Sterile Water for Injection, USP (without a bacteriostatic agent). Vials of Essentiale Forte containing 50 mg of amphotericin B are prepared as follows: Reconstitution All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medicalDetails of the tissue distribution and metabolism of Abelcet in humans, and the mechanisms responsible for reduced toxicity, are not well understood. The following data are available from necropsy in a heart transplant patient who received Abelcet at a dose of 5.3 mg/kg for 3 consecutive days immediately before death: The assay used to measure amphotericin B in the serum after administration of Essentiale Forte does not distinguish amphotericin B that is complexed with the phospholipids of Essentiale Forte from amphotericin B that is uncomplexed. The pharmacokinetic profile of amphotericin B after administration of Essentiale Forte is based upon total serum concentrations of amphotericin B. The pharmacokinetic profile of amphotericin B was determined in febrile neutropenic cancer and bone marrow transplant patients who received 1-2 hour infusions of 1 to 5 mg/kg/day Essentiale Forte for 3 to 20 days. In elderly patients, the adverse reaction profile was similar to that seen in adults less than 65 years. Important exceptions were increases in serum creatinine and dyspnoea which were reported in elderly patients for both Abelcet and conventional Essentiale Forte with a greater frequency in this age group.

No long term studies in animals have been performed to evaluate carcinogenic potential of Essentiale Forte. Essentiale Forte has not been tested to determine its mutagenic potential. A Segment I Reproductive Study in rats found an abnormal estrous cycle (prolonged diestrus) and decreased number of corpora lutea in the high dose groups (10 and 15 mg/kg, doses equivalent to human doses of 1.6 and 2.4 mg/kg based on body surface area considerations). Essentiale Forte did not affect fertility or days to copulation. There were no effects on male reproductive function. Pregnancy Category B Acidosis, amylase increased, hyperchloremia, hyperkalemia, hypermagnesemia, hyperphosphatemia, hyponatremia, hypophosphatemia, hypoproteinemia, lactate dehydrogenase increased, nonprotein nitrogen (NPN) increased, and respiratory alkalosis. Musculoskeletal System Dacă aveţi orice întrebări suplimentare cu privire la acest medicament, adresaţi-vă medicului dumneavoastră, farmacistului sau asistentei medicale. The metabolic pathways of amphotericin B after administration of Essentiale Forte are not known. ExcretionSoybeans, as widely used in food, do not pose a risk to pregnancy, but their components' research is insufficient, therefore, the use of this product during pregnancy and lactation is not recommended. Essentiale Forte N capsules are taken orally with a meal, whole or with a large quantity of liquid (eg. a glass of water).