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for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences (BNLMS), Peking University, Beijing, China Measurements were performed using a Prometheus NT.48 instrument (NanoTemper Inc., Germany). ShhN was diluted to 0.2 mg/mL in buffer contained 10 mM HEPES, pH 7.4, 150 mM NaCl, and 5% DMSO. Measurements were carried out using 70% power with standard Prometheus NT.48 capillaries. The heating was 1.0°C/min from 20 to 95°C. Results and Discussion Discovery of ShhN–Ptch PPI Inhibitors

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