Judge Lord Sandison saw CCTV footage of Mr Brodie being forced onto the bonnet of the motor as Scales continued to drive. Because CRS management algorithms are based on CRS grade, different grading systems could result in patients receiving more aggressive or less aggressive treatment of the same CRS event depending on the criteria used at each institution, unless treating physicians use a CAR-T product–specific scale, which is impracticable. An important benefit of standardizing CAR-T therapy–associated CRS grading criteria will be standardization of CRS management algorithms. In the JULIET trial, tocilizumab was recommended for CRS with worsening symptoms, with respiratory distress requiring high-flow oxygen and/or mechanical ventilation, or with hypotension requiring moderate- to high-dose vasopressor intervention (ie, symptoms equivalent to Penn grades 3 and 4 CRS, respectively). Thus, only 14% of patients received tocilizumab in the JULIET trial. Conversely, the modified CRS treatment guidance cited in ZUMA-1 suggested considering tocilizumab treatment of CRS starting at Lee grade 2, resulting in 45% of enrolled patients receiving at least 1 tocilizumab dose (supplemental Data). 5, 7, 14 It is difficult to directly compare 2 separate, single-arm, phase 2 trials with distinct patient populations. Furthermore, some patients in the JULIET trial were treated as outpatients, and CRS according to Lee grade was determined retrospectively. By comparison, the ZUMA-1 trial protocol required 7 days of hospitalization and close patient monitoring, and it may have captured additional AE data not recorded in JULIET patients in the outpatient setting. Nevertheless, Figure 2 4, 5, 7, 22 highlights the evolution of tocilizumab use for CRS treatment; indeed, tocilizumab treatment of CRS at lower grades has become more prevalent in real-world practice and may lower the likelihood of subsequent evolution to grade 3 or 4 CRS events, 23 - 25 obscuring the assessment of CAR-T product–related risk.

Sometimes we wish to weigh bullets (competitive bench rest shooters and cast bullet shooters might want to sort bullets by weight). On the Lee scale, you can only weigh bullets that are 110 grains or less. I’m what I would call a serious reloader, and in the last 50 years, I might have weighed bullets maybe a half dozen times. I’m happy to lose the ability to weigh bullets in exhange for the increased sensitivity I’ll get when weighing powder charges with the Lee scale. Your mileage may vary. Symptoms are not life-threatening and require symptomatic treatment only (eg, fever, nausea, fatigue, headache, myalgias, malaise) Applied Nano and Thermal Science Lab, Department of Mechanical Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea The most common discordance between CRS event grades was a higher Penn scale grade than either Lee or ASTCT grades. For example, 1 patient was evaluated as having grade 4 CRS according to both the Penn and Lee scales but no CRS according to the ASTCT criteria. This patient was admitted to an ICU 5 days postinfusion for a 12-day length of stay, required supplemental oxygen, and had hypotension treated with fluid resuscitation. Furthermore, this patient received tocilizumab therapy because the event was attributed to CRS. However, due to the absence of high fever, the experts unanimously agreed that CRS per the ASTCT criteria was not present. Otherwise, differences in CRS grading were often redefined based on the presence of hypotension, levels of administered supplemental oxygen, or the presence or absence of unique organ toxicity such as acute kidney injury, which would be scored according to the Lee criteria but not by the Penn or ASTCT criteria. For example, a patient had grade 3 CRS per the Penn scale due to a fever lasting 4 days and was admitted to an ICU for 4 days. The patient was not intubated but required oxygen supplementation at a maximum rate of 2 L/min and fluid resuscitation for blood pressure support. This patient did not receive any anticytokine therapy or corticosteroids. However, it was noted that the patient had a grade 3 (according to Common Terminology Criteria for Adverse Events version 4.03) infection concurrent with CRS. When going through the available records during regrading, it was impossible to differentiate CRS from infection. To be on the conservative side, all experts regraded this CRS event as grade 2 according to both the Lee and ASTCT criteria. He admitted to driving at excessive speed at Mr Brodie, causing him to collide with the car, and driving over thetop of him.It has a clever knife edge system consisting of a blade of razor sharp steel - this makes the beam very sensitive, most other scales have knife edges at 60 degrees, the difference of something like a cold chisel and a razor blade. A previous study asked patients to compare how they would report their symptoms with a 7 day or one month timeframe, showing that some patients reported the time frame selected would have altered their answers. The primary reason given was that their cGVHD symptoms had changed for better or worse in the past month which is a legitimate reason for different answers, further justifying the change to a shorter recall period. We share live crime news and exclusive court stories as well as features and columns on historical cases, keeping our readers informed and updated across the country.

Oxygen requirement <40% * or hypotension responsive to fluids or low-dose pressors or grade 2 organ toxicity The story emerged after Scales, a prisoner of HMP Edinburgh, pleaded guilty to a charge of attempted murder. The Vernier type 10th adjuster is a real fiddle to use and is far from foolproof.....Easy to be a whole grain out for an inexperienced user. The accused continued driving, running over the complainer and dragging him along the ground before drivingaway from the locus.”

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Autologous, CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy has greatly improved outcomes for patients with relapsed/refractory (r/r) hematologic malignancies. Two currently commercially available CD19-directed CAR-T therapy products, tisagenlecleucel and axicabtagene ciloleucel, have shown durable responses and improved overall survival compared with historical controls. 1 These findings were reported in the JULIET (A Phase 2, Single Arm, Multicenter Trial to Determine the Efficacy and Safety of CTL019 in Adult Patients With Relapsed or Refractory DLBCL) trial, enrolling patients with r/r diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma (tFL), and the ZUMA-1 (Long-Term Safety and Activity of Axicabtagene Ciloleucel in Refractory Large B-Cell Lymphoma) trial, enrolling patients with r/r DLBCL, tFL, and primary mediastinal B-cell lymphoma. 2 - 5 A third CD19-directed CAR-T therapy, JCAR017 (lisocabtagene maraleucel), is currently under investigation in B-cell non-Hodgkin lymphomas (# {"type":"clinical-trial","attrs":{"text":"NCT02631044","term_id":"NCT02631044"}}NCT02631044). 6 Several unique and commonly observed adverse events (AEs) are associated with CAR-T therapy across hematologic malignancies and require specialized management; these AEs include cytokine release syndrome (CRS) and neurologic toxicity. 3, 5, 7 - 10 Any-grade CRS occurs in many patients receiving CAR-T therapies, 11 - 13 including tisagenlecleucel (58%) or axicabtagene ciloleucel (93%), although cross-trial comparisons are difficult to interpret due to diverse trial designs and the differences in CRS reporting scales used. 3, 5 Sixteen of 111 patients in the JULIET trial (14%) and 49 of 108 patients in the ZUMA-1 trial (45%) received tocilizumab for CRS management, per different CRS management algorithms. 5, 7, 14 - 16 Iran (relating to nuclear weapons) (trade sanctions (including an arms embargo) and transit control)

I have read a Victim Impact Statement and listened to what your counsel Mr McSporran has said on your behalf. Lee Scales, 28, drove a red Ford Fiesta at Spencer Brodie outside the Westside Plaza Shopping Centre in WesterHailes, Edinburgh, on April 14, 2022.This was so they could “sort out” their disagreement.The lawyer added: “It arose out of the most trivial nonsense. Understanding the structure of an RDF “Graph” of data can be more effort than tabular (Excel/CSV) or tree (XML/JSON) data. George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA, 30332, USA She added: “The accused accelerated towards the complainer at speed, hitting the complainer and causing himto fall onto the bonnet of the car.