Crafted in the USA under stringent manufacturing processes, these capsules are free from yeast, soy, gluten, peanuts, eggs, preservatives, and binders, making them accessible to a wide range of dietary needs.

Luteolin is a plant-based supplement that has a wide range of potential health benefits. It is most commonly taken in pill form, but it can also be found in some teas and foods.Start with the recommended dosage: Follow the instructions provided by the manufacturer or your healthcare provider regarding the appropriate dosage. The dosage may vary depending on the concentration of luteolin in the supplement. Tan X, Yang Y, Xu J, Zhang P, Deng R, Mao Y, He J, Chen Y, Zhang Y, Ding J, et al. Luteolin exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 pathway in Intracerebral Hemorrhage. Front Pharmacol. 2019;10:1551. Zhao Y, Yang G, Ren D, Zhang X, Yin Q, Sun X. Luteolin suppresses growth and migration of human lung cancer cells. Mol Biol Rep. 2011;38(2):1115–9.

Han K, Meng W, Zhang JJ, Zhou Y, Wang YL, Su Y, Lin SC, Gan ZH, Sun YN, Min DL. Luteolin inhibited proliferation and induced apoptosis of prostate cancer cells through miR-301. Onco Targets Ther. 2016;9:3085–94. P53 signaling is closely related with the induction or suppression of autophagy thereby presenting a desirable approach towards the anticancer therapy. Functioning as a nuclear transcription factor and mediating the transactivation of proapoptotic, cell cycle arresting proautophagic genes, p53 is considered as a master regulator of autophagy depending on its subcellular localization. Yoo et al. [ 28] reported the anticancer effect of luteolin due to the induction of apoptosis and autophagy in colon cancer cells. In the presence of luteolin, the HCT116 cells showed heightened phosphorylation of p53 and p53 target gene expression eventually resulting in apoptosis and cell cycle arrest. Autophagy is induced by luteolin in p53 wild-type cells and not in mutant p53 cells. This evidence suggests that autophagy by luteolin is p53 dependent. Luteolin is also found to arrest cell cycle in G2/M phase in addition to the induction of apoptosis in human colon cancer cells xenografts. The flow cytometric analysis has validated the observation that luteolin promotes cell cycle arrest in G2/M phase and induces apoptosis in LoVo human colon cancer cells in time- and dose-dependent manner. Similar observation is obtained with western blot analysis which revealed that luteolin posed inhibitory effect on cell proliferation on LoVo cells by arresting cell cycle at G2/M phase transition and inactivated cyclin B1 and cell division cycle 2. These events are mediated by cytochrome c and deoxyadenosine triphosphate-mediated activation of apoptotic protease activating factor 1. Further in vivo analysis suggested a decrease in the body weight of colon tumor mice. Overall, these findings indicated chemopreventive and chemotherapeutic effect of luteolin against human colon cancer [ 24].Dong H, Yang X, He J, Cai S, Xiao K, Zhu L. Enhanced antioxidant activity, antibacterial activity and hypoglycemic effect of luteolin by complexation with manganese(ii) and its inhibition kinetics on xanthine oxidase. RSC Adv. 2017;7(84):53385–95. In the plants, the flavonoid often stays in the glycosylated form. However, when humans use them, the glycoside is hydrolyzed, which results in freeing the Luteolin, thus helping in the absorption process. What makes this flavonoid unique is that it is heat stable.

Kang KA, Piao MJ, Hyun YJ, Zhen AX, Cho SJ, Ahn MJ, Yi JM, Hyun JW. Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells. Exp Mol Med. 2019;51(4):1–14. Formulated with a commitment to purity and potency, these vegetarian capsules cater to those embracing a vegetarian lifestyle. Horbaach’s expertise ensures a professional-grade formula that meets stringent quality standards. Cao D, Zhu GY, Lu Y, Yang A, Chen D, Huang HJ, Peng SX, Chen LW, Li YW. Luteolin suppresses epithelial-mesenchymal transition and migration of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Biomed Pharmacother. 2020;129:110462. Similarly, the protein levels of p62 downregulated while that of LC3-II is upregulated following the luteolin treatment in p53 wild type HepG2 cells indicating the induction of autophagy. This evidence was further validated by analyzing the number of viable cells in the presence of luteolin and autophagy inhibitors 3-methyladenine and chloroquine where the number of viable cells considerably lowered. Luteolin-induced autophagy in cancer cells was further validated by Lee et al. [ 30]. The A172 and U-373MG cells treated with luteolin showed reduced viability in concentration- and dose-dependent manner. At a concentration above 100 µM, the nucleus of these cells undergoes fragmentation and characteristic morphological changes start to appear that confirm the onset of apoptosis. Notably, the fragmentation of apoptosis-related factors caspase-3, and poly(ADP-ribose) polymerase (PARP) was observed that further confirms the onset of apoptosis at 50 µM concentration.

The best foods with luteolin, according to a nutritional psychiatrist

Lee Y, Kwon YH. Regulation of apoptosis and autophagy by luteolin in human hepatocellular cancer Hep3B cells. Biochem Biophys Res Commun. 2019;517(4):617–22. Third-party laboratory testing guarantees the purity and quality of the product, reinforcing its reliability. Phytochemicals offer a resolute anticancer profile by providing novel pharmacophores and bioactive molecules that not only inhibit the development and progression of cancers by modulating the key regulatory pathways but ameliorate the chemo-sensitization of cancer cells. In addition to this, anticancer phytochemicals simultaneously target diverse, interconnected oncological pathways that further prevent the relapse and evade the resistance mechanisms in oncologic cells [ 2]. Of the diverse nature of anti-oncologic phytochemicals, the phenolics present a commendable profile with multifaceted modes of action towards cancer-associated pathways. Discover the potent blend of plant-based flavonoids in Horbaach’s Luteolin Complex, offering 50 mg each of Luteolin and Rutin in every capsule.