Himalaya SEPTILIN, Herbal Supplement -100 Tablets (2 Pack)

Product Information

reduce riscul contractării gripei și al altor viroze respiratorii, atât la adulți, cât și la copii, recomandându-se de la primele simptome ale bolii; Micronuclei (MN) are chromatin containing bodies, appearing as small satellite nucleus in the cell arising from acentric chromosomal fragments or from entire chromosome that is lagging at anaphase [56], [89], [81]. Presence of micronuclei in cells is an indicator of damage to the DNA. The in vivo micronucleus tests using haematopoietic bone marrow and peripheral blood cells are widely used methods for the assessment of genotoxicity of chemicals in exposed organisms. The rodent bone marrow micronucleus assay is the measure of both clastogenicity/aneugenicity of target chemical [59]. It has helped a lot to understand the dose response relationship for aneugens and clastogens [23]. Micronucleus is a biomarker, which is used widely in biomonitoring studies to determine the genetic risk due to the exposure to environmental chemicals [10]. Presence of micronuclei in the peripheral blood is found to be as an important biomarker, which shows the risk of cancer development [11], [25]. Hernandez et al. [36] investigated the applicability of MN data to derive cancer potency information. They explored relationship between dose response data from genotoxicity tests and carcinogenicity studies and they observed a positive correlation between these two. CP is a well-known anticancer, chemotherapeutic and immunosuppressive drug, which was used as a clastogenic agent in the present study. The results obtained in this study revealed the protective effects of the septilin against the genotoxicity of CP in mouse. Administration of CP alone induced significant micronuclei in both bone marrow and peripheral blood cells and also it reduced the P/N ratio in bone marrow cells. Although CP has potent therapeutic value it also shows wide spectrum of cytotoxicity against normal cells which is a hindrance for its usage. The cytotoxicity of drug is mainly due to its ability to damage DNA. CP is an alkylating agent and its alkyl group can bond with nucleic acids resulting in DNA strand breaks, micronuclei formation and ultimately by the cell death [37]. CP showed significant effects in all the parameters used. In the combined treatment groups, septilin significantly reduced MN induced by CP and it enhanced the P/N ratio significantly. In the peripheral blood also CP significantly reduced the mean percent of PCE, and also it reduced the frequency of MN in NCE induced by CP. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Am incercat la recomandare pediatru -Bronhovaxom - racea imediat dupa primele zile de administrare, Rybomunil,Lantigenb..insa nu am rezolvat mare lucru The sperm morphology assay, is one of the most widely used genetic toxicology assays, has potential in identifying chemicals that induce spermatogenic dysfunction and perhaps heritable mutations Wyrobek [107]. Furthermore, the development of sperm head abnormality has been used as a reliable short-term biological indicator in the evaluation of chemical genotoxicity [53], [29]. In the present findings, significant increase in the percentage of sperm head abnormalities, reduced relative testes weight and sperm count were observed in the CP treated group. Pretreatment of animals with septilin significantly decreased the percentage of abnormal sperms and there was an increase in the sperm count and relative testes weight, which demonstrate the protective effect of septilin on germinal cells.

Key ingredients

There are many reports on the protective effects of individual plants present in the septilin. Parvaiz et al. [68], Roshan et al. [76] and Saxena [80] reviewed the medicinal properties of Glycyrrhiza glabra including anticancer and antioxidant effects. There are several review articles on the pharmacological properties of Glycyrrhiza glabra and its bioactive compounds [16], [2], [5], [30], [43], [102], [34]. acute and chronic inflammation of the respiratory system, asthma, tuberculosis, dry and wet cough, asthmatic cough, chronic foggy, constant clearing, bronchitis, infections of the upper and lower respiratory tract, Each participant received two different treatments in different areas of their mouth. One area received the SRP treatment only, while the other area received a combination of SRP treatment and AVG injections into the gums. The researchers concluded that chewing green tea gum may help treat gum inflammation when used in combination with other gingivitis treatments. 4. Aloe vera gel Tripathi, P., et al. (2019). Antioxidant therapy (lycopene and green tea extract) in periodontal disease: A promising paradigm.

Thosar N. (2013). Antimicrobial efficacy of fiveessential oils against oral pathogens: An in vitro study. DOI: The main ingredients of Septilin (Tablets & Syrup) are Tinospora (Guduchi), Licorice ( Yashtimadhu or Mulethi) and Indian Bdellium (Guggulu). Septilin Syrup Composition INGREDIENT Although it is difficult to elucidate the exact mechanism of antigenotoxic effect of septilin, it could be possible to explain the reasons for these effects based on some of the related studies conducted by different investigators. Vilar et al. [106] studied the antimutagenecity protection of Ginkgo biloba extract against mitomycin C and CP in mouse bone marrow. According to them there are some common mechanism of action of plant extracts such as antioxidant activity, free radical scavenging and even the gene regulation which contributes its direct or indirect anti mutagenic effects. CP is an alkylating anticancer drug which is activated in vivo by passing through various metabolic steps producing reactive molecules. Scavenging of these reactive molecules is one of the important techniques in the armoury of antimutagenesis. This may be one reason for the protective effect of septilin. Similar hypothesis has been given by Hosseinimehr and Karami [37] while reporting the chemoprotective effects of captopril against CP induced genotoxicity. They reported the reduction of CP induced genotoxicity in bone marrow cells and they opine that this effect is due to the antioxidant activity of thiols in captopril. In our own study, we observed the antioxidant effects of septilin against CP, as revealed by significant enhancement of liver SOD and GSH in the combined treatment group (to be published elsewhere). Alija et al. [3] studied the cytotoxic and genotoxic effects of β- carotene and its cleavage products (CP) in rat hepatocytes. They opine that the genotoxic effects may be due to the prooxidant properties of CP or direct or indirect action on DNA. Delarmelina reported the antimutagenic activity of ipriflavone against DNA damage induced by CP in mice. Probable mechanisms proposed by them are desmutagenesis or bio antimutagenesis. Although in the present study it is difficult to elucidate the mechanisms, septilin is containing extracts of various plants which possess flavonoids thereby eliciting protective effects. There are several reports on such effects of plant extracts, bioactive constituents and natural compounds. Flavonoids are the phenolic compounds which are naturally found in fruits, vegetables and other plant parts. They have many favourable biological effects due to their antioxidant and free radical scavenging abilities. However, at higher doses they act as prooxidants. Prooxidants show cytotoxic and clastogenic properties [113]. Tourino et al. [99] reported the antioxidant/prooxidant effects of bioactive polyphenolics. According to them the most effective antioxidants are also the most cytotoxic and effective anti-proliferative agents, may be due to the dual antioxidant/prooxidant effect of polyphenols. Although, various doses of septilin showed significant genoprotective effect against CP, maximum effect was observed at middle dose (250mg/kg b.w.) and there was no increased effect at highest dose. There are several reports on the phytocomponents of individual plants extract present in septilin, which are known biological protective agents. Sharma and Agrawal [87] studied the antigenotoxic effects of Glycyrrhiza glabra root extract against CP induced chromosomal aberration in Swiss albino mice. According to them the protective effect is due to the reduced immunosuppressant effects of CP by Glycyrrhiza glabra and presence of the phytotherapeutic molecules such as flavonoids, tannins, saponins, triterpinoids in this plant. Parvaiz et al. [68] also reported the presence of these compounds in a review on this plant. Pendli et al. [69] carried out phytochemical analysis of extracts of various plant parts of Rubia cordifolia Promkum et al. [72] studied anticlastogenic effects of Moringa oleifera against mitimycin C (MMC) and 7, 12-dimethyl benz( a)anthracene, potent clastogens. They are of the view that the protective effect of this plant due to the presence of various nutrients and phytochemical compounds such as β-carotene, vitamins and various phenolics. Torres-Castillo et al. [98] reported the presence of polyphenols, alkaloids and saponins in Moringa oleifera. Tinospora Gulancha (Guduchi) is a potent antimicrobial that has immunomodulatory properties, which helps in increasing the level of antibodies. This helps in building up the body’s resistance to infections.

Septilin Dosage

Dosage: Do not exceed the recommended dosage of Septilin Tablet. Overdosing may lead to adverse reactions. Whether you are dealing with recurring colds or simply want to strengthen your immune system, these Septilin tablets are the perfect solution. With its unique blend of natural ingredients, this supplement helps improve your overall health and well-being. What sets Septilin tablet apart from other immune-boosting supplements is its all-natural formulation. It is carefully crafted with herbal ingredients that have been used in traditional medicine for centuries. This ensures that you are getting a safe and effective product with no harmful side effects. Moghaddam, A. A., et al. (2017). Clinical evaluation of effects of local application of aloe vera gel as an adjunct to scaling and root planning in patients with chronic periodontitis.

Below are some natural remedies that people can use alongside standard treatments for gum recession. 1. Oil pulling They together provide immunity, antioxidants, antimicrobial and anti-inflammatory properties. The dosage of septilin syrupEnhances respiratory health: Septilin Tablet helps in the treatment of respiratory tract infections such as bronchitis, asthma, and sinusitis. It also helps relieve symptoms such as cough, cold, and sore throat. Do you easily get infected by a sore throat or cold flu? Have consulted the best physician and taken the antibiotic to treat infection but still get infected easily. Actually, your immune system is not strong enough to protect you from external and internal threats. Don’t be stressed out as you can enhance your immune system naturally by consuming septilin (tablet & syrup) Ayurvedic medicine as it contains the blend of various herbs providing the benefits for a healthy life. Known manufacturer of septilin is Himalaya herbal healthcare. It provides the immunomodulatory action in the body and stimulates natural killer cells which target foreign infections. Composition of Septilin (Tablet & Syrup) Improves skin health: Septilin Tablet has antioxidant properties that help protect the skin from free radical damage. It also helps in the treatment of skin infections such as acne and eczema. Deore GD, et al. (2014). Herbalanti-inflammatory immunomodulators as host modulators in chronic periodontitispatients: A randomised, double-blind, placebo-controlled, clinical trial.