The extent of absorption of cetirizine is not reduced with food, although the rate of absorption is decreased. The extent of bioavailability is similar when cetirizine is given as solutions, capsules or tablets. Diphenhydramine can pass into breast milk and may harm a nursing baby. Antihistamines may also slow breast milk production. Ask a doctor before using this medicine if you are breast-feeding. If you forget to take a dose, take the next dose when needed provided that you only take a maximum of 1 capsule in 24 hours. Do not take a double dose. Undesirable effects are described according to MedDRA System Organ Class and by estimated frequency based on the post-marketing experience. In a placebo-controlled study, cetirizine given at the high daily dose of 60 mg for seven days did not cause statistically significant prolongation of QT interval.

The steady - state peak plasma concentrations is approximately 300 ng/ml and is achieved within 1.0 ± 0.5 h. No accumulation is observed for cetirizine following daily doses of 10 mg for 10 days. The distribution of pharmacokinetic parameters such as peak plasma concentration (C max) and area under curve (AUC), is unimodal in human volunteers. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with cetirizine. Just because a side effect is stated here doesn't mean that all people taking this medicine will experience that or any side effect. Common side effects (affect between 1 in 10 and 1 in 100 people)Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially: Women who are pregnant. If you suffer with allergies during pregnancy you should get advice from your doctor on how to treat your symptoms, because locally acting medicines like nasal sprays are usually preferred. Cetirizine can be used if necessary, but only if the benefits outweigh any risks and only if it's prescribed by your doctor. Treatments Find every kind of best treatment near you, We British Chemist UK online pharmacy retailer and registered pharmacy with the MHRA and GPhC. Hepatically impaired patients: Patients with chronic liver diseases (hepatocellular, cholestatic, and biliary cirrhosis) given 10 or 20 mg of cetirizine as a single dose had a 50 % increase in half-life along with a 40 % decrease in clearance compared to healthy subjects. In a 35-day study in children aged 5 to 12, no tolerance to the antihistaminic effect (suppression of wheal and flare) of cetirizine was found. When a treatment with cetirizine is stopped after repeated administration, the skin recovers its normal reactivity to histamine within 3 days.

Patients on haemodialysis (creatinine clearance less than 7 ml/min) given a single oral 10 mg dose of cetirizine had a 3-fold increase in half-life and a 70 % decrease in clearance compared to normal. Cetirizine was poorly cleared by haemodialysis. Dosing adjustment is necessary in patients with moderate or severe renal impairment (see section 4.2). Since Benadryl is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose?Cetirizine does not undergo extensive first pass metabolism. About two third of the dose are excreted unchanged in urine. The terminal half-life is approximately 10 hours. Express Delivery (1-2 Working Days) ( Excluding Saturday Delivery) (Please be aware when you select Courier Next Day for northern parts of Scotland, DPD may take 2 days to deliver) Studies in healthy volunteers show that cetirizine, at doses of 5 and 10 mg strongly inhibits the wheal and flare reactions induced by very high concentrations of histamine into the skin, but the correlation with efficacy is not established. If you have ever had a reaction to this product or to any of its ingredients or the antihistamine Triprolidine.