Serpell M. (2014). A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment. Everyone’s experience with CBD is likely to be unique, but for optimal results, CBD should be used consistently over a few weeks or months. The cannabidiol needs time to build up in your system, much like vitamin supplements, so effects are likely to become more enhanced over time. CBD sprays make it simple and easy to get your daily dose of CBD. How Do CBD Sprays Work? Patients on hormonal contraceptives should be advised to use an additional alternative, non-hormonal/reliable barrier method of birth control during Sativex therapy. One 2019 review also suggests that cannabinoids may help prevent other adverse effects associated with chemotherapy, including poor appetite and pain. That said, the evidence in this area is weak. Chronic pain

In vitro, Sativex was observed to be a reversible inhibitor of CYP3A4, 1A2, 2B6, 2C9 and 2C19 at concentrations far in excess of those likely to be achieved clinically. In vitro investigations also demonstrated that Sativex had the potential for time dependent inhibition of CYP3A4 at clinically relevant concentrations. The rate of the inactivation of the CYP3A4 enzyme is expected to be rapid. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. We have various strengths of our high quality CBD oils: 600mg, 1200mg, 2400mg and 4800mg. See below for more information. No psychoactive effects Treatment must be initiated and supervised by a physician with specialist expertise in treating this patient population.Available pharmacodynamics / toxicological data in animals have shown excretion of Sativex / metabolites in milk (for details see section 5.3). Although there is a theoretical risk that there may be an additive effect with muscle-relaxing agents such as baclofen and benzodiazepines, thereby increasing the risk of falls, this has not been seen in clinical trials with Sativex. However, patients should be warned of this possibility. People undergoing chemotherapy for cancer may experience nausea and vomiting. Doctors usually prescribe antiemetics to counteract these unpleasant side effects. However, there has been little research into the benefits of CBD for milder, more common forms of epilepsy. Addiction

Alterations in pulse rate and blood pressure have been observed following initial dose introduction so caution during initial dose titration is essential. Fainting episodes have been observed with use of Sativex. Use of Sativex is not recommended in patients with serious cardiovascular disease. However, following dosing in healthy volunteers with Sativex up to 18 sprays twice daily, there were no clinically relevant changes in QTc, PR or QRS interval duration, heart rate, or blood pressure.Millar, S. A., et al. (2018). A systematic review on the pharmacokinetics of cannabidiol in humans. hallucination (unspecified, auditory, visual), illusion, paranoia, suicidal ideation, delusional perception* any special action to learn your age, if we learn that you are under 18 years of age, we will not sell to you, maintain or use any personally identifiable information about you. If you believe your minor-child has provided personally