If the symptoms worsen during the use of the medicinal product, or there is no bowel movement after three days, a doctor or pharmacist should be consulted. Overuse of laxatives can cause the colon to stop reacting to usual doses of laxatives so that larger and larger amounts of laxatives may be needed to produce bowel movements. Most data refer to extracts of senna pods containing 1.4 to 3.5% of anthranoids, corresponding to 0.9 to 2.3% of potential rhein, 0.05 to 0.15% of potential aloe-emodin and 0.001 to 0.006% of potential emodin or isolated active constituents, e.g. rhein or sennosides A and B. The acute toxicity of senna pods, specified extracts thereof, as well as of sennosides in rats and mice was low after oral treatment. If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. If you take too much

In a 90-day rat study, senna pods were administered at dose levels from 100 mg/kg up to 1,500 mg/kg. The tested drug contained 1.83 % sennosides A-D, 1.6 % potential rhein, 0.11 % potential aloe-emodin and 0.014 % potential emodin. In all groups epithelial hyperplasia of the large intestine of minor degree was found and was reversible within the 8-week recovery period. The hyperplastic lesions of the forestomach epithelium were reversible as well. Dose-dependent tubular basophilia and epithelial hypertrophy of the kidneys were seen at a dose of, or greater than 300 mg/kg per day without functional affection. These changes were also reversible. Storage of a brown tubular pigment led to a dark discoloration of the renal surface and still remained to a lesser degree after the recovery period. No alterations were seen in the colonic nervous plexus. A no-observable-effect-level (NOEL) could not be obtained in this study.A 104-week study on rats of both genders did not reveal any carcinogenic effects with the same senna pods preparation at oral dosages of up to 300 mg/kg. Prolonged use may precipitate the onset of an atonic, non-functioning colon. Prolonged excessive use may lead to fluid and electrolyte imbalance and hypokalaemia. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Symptoms and treatment of overdosage: The major symptoms of overdose or abuse of any stimulant laxative, including those containing senna, are griping pain and severe diarrhea, leading to excessive water loss (dehydration) and possible electrolyte imbalance (hypokalemia).

Do not take Senokot Max Strength tablets for more than one week. If they haven't been effective by this point you should see your doctor.Take senna for a few days only and no longer than a week. If you take it for longer, your body can start to rely on it, rather than your bowels doing the work on their own.

If other adverse professionals reactions not mentioned above occur, a doctor or a qualified healthcare practitioner should be consulted. Only give senna that you buy to a young person aged 12 to 17 years if a doctor or pharmacist recommends it. Dosage for senna tablets prescribed by a doctor The sugar moiety of the sennosides is removed by bacteria in the large intestine releasing the active anthrone fraction. This stimulates peristalsis via the submucosal and myenteric nerve plexuses. In cases of intestinal obstructions and stenosis, atony, appendicitis, inflammatory colon diseases (e.g Crohn's disease, ulcerative colitis), abdominal pain of unknown origin, severe dehydration state with water and electrolyte depletion.

It's Time to Get Poopin'.

SENOKOT ®•S can be found at your local pharmacy and in many popular and convenient stores across Canada. Samples may be available through your family physician. In addition a specified senna extract given orally for 2 years was not carcinogenic in male or female rats. The extract investigated contained approximately 40.8% of anthranoids from which 35% were sennosides, corresponding to about 25.2% of potential rhein, 2.3% of potential aloe-emodin and 0.007% of potential emodin and 142 ppm free aloe-emodin and 9 ppm free emodin.

ACTIVE INGREDIENTS: Each SENOKOT ® for Women tablet contains 8.6 mg standardized sennosides from natural senna.New medications or inadequate physical activity are both factors that contribute to constipation after surgery. Your physician may recommend a laxative if you are recovering from surgery and having problems with constipation. Treatment should be supported with generous amounts of fluid. Electrolytes, especially potassium, should be monitored. This is especially important in the elderly. In case of overdose: Call a Regional Poison Control Centre and/or your physician and/or your local emergency number immediately, or go to your local hospital emergency, even if you do not notice any signs or symptoms. Keep all medicines out of the reach of children. Long-term use of stimulant laxatives should be avoided, as use for more than a brief period of treatment may lead to impaired function of the intestine and dependence on laxatives. If laxatives are needed every day the cause of the constipation should be investigated. This product should only be used if a therapeutic effect cannot be achieved by a change of diet or the administration of bulk forming agents. SENOKOT ®•S should not be taken within two hours of another medicine as it may reduce the effectiveness of other medicine. Drugs that may interact with SENOKOT ®•S include: cardiac medications such as cardiac glycosides (drugs that increase the force of contraction of the heart) or antiarrhythmic medications (drugs that restore the normal rhythm of the heart); mineral oil; thiazide diuretics (drugs used to treat high blood pressure), corticosteroids, licorice root or other medications or health products which may aggravate electrolyte imbalance.