Contain different sound files/waves that mimics the effect produced by certain drugs on the nervous system. Desikan RS, Schork AJ, Wang Y et al (2015) Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation 131:2061–2069. doi: 10.1161/CIRCULATIONAHA.115.015489 Lee VM, Goedert M, Trojanowski JQ (2001) Neurodegenerative tauopathies. Annu Rev Neurosci. doi: 10.1146/annurev.neuro.24.1.1121 Department of Neurology, Technical University of Munich, Munich, Germany and German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USAThe first thing you'll notice when you run PPSSPP (developed by one of the authors of Dolphin, the most powerful Gamecube and Wii emulator out there) for the first time is the large number of setting options. You can activate Vsync, anisotropic filtering and texture scaling, among others.

Karch CM, Ezerskiy LA, Bertelsen S, Goate AM, ADGC (2016) Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717Bang J, Spina S, Miller BL (2015) Frontotemporal dementia. Lancet 386:1672–1682. doi: 10.1016/S0140-6736(15)00461-4 Hawrylycz M, Miller JA, Menon V et al (2015) Canonical genetic signatures of the adult human brain. Nat Neurosci 18:1832–1844. doi: 10.1038/nn.4171 A full-fledged portal application for PSP with features such as games, chat applications, as well as some new ones. Vandrovcova J, Anaya F, Kay V et al (2010) Disentangling the role of the tau gene locus in sporadic tauopathies. Curr Alzheimer Res 7:726–734 PPSSPP is an excellent way to enjoy a good chunk of the PSP catalog using your Android device. Best of all, not only can you comfortably play all the games mentioned, but you can play them with better graphic quality than in their original versions. Reviewed by Andrés López Translated by Uptodown Localization Team Requirements (Latest version)

Trabzuni D, Wray S, Vandrovcova J et al (2012) MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Hum Mol Genet 21:4094–4103. doi: 10.1093/hmg/dds238Braak H, Del Tredici K (2015) The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease. Brain 138:2814–2833. doi: 10.1093/brain/awv236 Lipfert J, Ödemis V, Wagner DC, Boltze J, Engele J (2013) CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia. Neuropathol Appl Neurobiol 39:667–680. doi: 10.1111/nan.12015 And if the plethora of configuration options were not enough, PPSSPP also comes with every conceivable option for configuring the controls. You will not need to use Joy2Key or anything like that, because the emulator comes with its own intuitive tool that takes care of everything. Yokoyama JS, Wang Y, Schork AJ et al (2016) Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurol 94158:1–7. doi: 10.1001/jamaneurol.2016.0150

PPSSPP is an emulator for Sony´s first handheld console, the PSP (PlayStation Portable), that is capable of playing the majority games on your laptop or desktop computer, including the increase in resolution that this brings with it. Ferrari R, Hernandez DG, Nalls MA et al (2014) Frontotemporal dementia and its subtypes: a genome-wide association study. Lancet Neurol 13:686–699. doi: 10.1016/S1474-4422(14)70065-1 Desikan RS, Schork AJ, Wang Y et al (2015) Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus. Mol Psychiatry 1–8:1588. doi: 10.1038/mp.2015.6 A muisc application that gives you the chance to jam away using both drums and guitar for hours on end. A music player that supports a variety of formats, such as OGG Vorbis, Amiga SC68, MP3, WAV, and FLAC.

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia