Other Ingredients: Vegetable capsule (natural vegetable cellulose, water), vegetable stearic acid, magnesium stearate, microcrystalline cellulose, silicon dioxide. H. Dresler, et al., “Effect of PectaSol-C Modified Citrus Pectin (P-MCP) Treatment (tx) on PSA Dynamics in Non-Metastatic Biochemically Relapsed Prostate Cancer (BRPC) Patients (pts): Results of a Prospective Phase II Study,” Eur. Urol Suppl. 17(14): e2849 (2018). MCP can enhance the anti-cancer action of natural compounds. In a 2012 study (1) a compound including MCP, extracts from medicinal mushrooms, herbs such as astragalus, curcumin and Scutellaria plus I3C/DIM and quercitin, was shown to cut the progression of Triple negative breast cancer to the lungs by two thirds. One randomized clinical trial with 125 participants who had mild to moderate high LDL (low-density lipoprotein) cholesterol found that use of guar gum plus pectin helped to normalize cholesterol levels.

The most well-established pathogenic role of Gal-3 is in the development and migration of cancer. Gal-3 is over-expressed on the surface of cancer cells, acting as the primary adhesion molecule that allows cancers to proliferate, metastasize and evade the immune system. Several studies have indicated that pectin induces apoptosis in human colon cancer cells ( Table 1). The suppression of HT-29 colon cancer cell proliferation and cell cycle progression was explored by using potato (rhamnogalacturonan) pectin [ 28]. They found potato rhamnogalacturonan I domain-rich pectin (p-RG-I) reduced HT-29 cell growth and caused G2/M cell cycle arrest characterized by decreased CCNB1 and cyclin-dependent kinase 1 ( CDK1) expression. Real-time quantitative reverse transcription PCR (qRT-PCR) was used to detect mRNA levels of cell cycle arrest protein [ 28], and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test and flow cytometry to assess proliferation and cell cycle distribution. They found p-RG-I to have a dose-dependent effect on cell growth inhibition based on the MTT test. Cell proliferation was decreased to 90%, 79%, 67%, and 55% of control after 72 h of treatment with p-RG-I at concentrations of 0.6, 1, 25, 2, and 5 mg/mL, respectively [ 29]. Another study found ultrasonic modified sweet potato pectin (SSPP) induced apoptosis-like cell death in colon cancer (HT-29) cell lines in a dose-dependent manner in vitro. Moreover, the anticancer activity of 400 W SSPP was much higher than that of 1 or 3 mg/mL of heat-fragmented CP in BCaP-37 and HT-29 cell lines, which has been shown to induce over 50% cell death in HepG2 and A549 cell lines [ 30]. Moreover, both 0.5 mg/mL 200 W and 400 W SSPP induced a significant percentage of apoptotic cells [ 31], increasing caspase 3 (CASP3) activity, the last step of apoptosis, and phosphatidylserine (PS) release, indicative of intermediate apoptotic phases [ 32]. We recommend taking other supplements and medications spaced apart from PectaSol. One of PectaSol’s most impressive features is its proven ability to enhance the effects of other compounds and therapies, from herbs and botanicals, to conventional oncology agents. But the loss of important minerals may not occur with use of modified citrus pectin, as evidenced by a recent study on urinary excretion of toxic elements in healthy individuals. Knopp RH, Superko HR, Davidson M, Insull W, Dujovne CA, Kwiterovich PO, et al. Long-term blood cholesterol-lowering effects of a dietary fiber supplement. Am J Prev Med. 1999 Jul;17(1):18–23. DOI: 10.1016/s0749-3797(99)00039-2. PMID: 10429748.

Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, et al. The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Altern Ther Health Med. 2008 Aug;14(4):34–8. PMID: 18616067. Studies on the effect of pectin in myeloma therapy are ongoing. Alkali-soluble pectin reduces immunoglobulin E (IgE) production in human myeloma cell line U266 in a study examining the effects of water- (WP), hexametaphosphate- (HXP), acid- (HP), and alkali-soluble (OHP) pectin solutions. However, whereas OP altered cell viability, WP, HXP, and HP did not. Moreover, pectin increased the proportion of IL-2 receptor (IL-2R)-positive cells in mesenteric lymph node (MLN) lymphocytes, indicating that its immunoglobulin modifying effect was mediated by activated Th1 cells [ 58].

Exhibited size-induced prolonged circulation as well as ASGP receptor-mediated targeting ability to cancer cell lines Guess BW, Scholz MC, Strum SB, Lam RY, Johnson HJ, Jennrich RI. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer Prostatic Dis. 2003;6(4):301–4. DOI: 10.1038/sj.pcan.4500679. PMID: 14663471. Azémar M, Hildenbrand B, Haering B, Heim ME, Unger C. Clinical Benefit in Patients with Advanced Solid Tumors Treated with Modified Citrus Pectin: A Prospective Pilot Study. Clin Med Oncol. 2007 Jan;1:CMO.S285. DOI: 10.4137/CMO.S285. Additional inflammatory conditions, including liver and kidney disease, arthritis, obesity, neurodegeneration and infection have all shown a significant reduction by this researched form of MCP. In 2018, for example, clinical results from an ongoing multicentre trial on this form of MCP in biochemically relapsed prostate cancer were presented at the American Society for Clinical Oncology Genitourinary Conference. Reported in the Journal of Clinical Oncology, the study — “Effects of Pectasol-C Modified Citrus Pectin Treatment on PSA Dynamics in Non-Metastatic Biochemically Relapsed Prostate Cancer Patients” — demonstrated the ability of the only researched form of MCP to significantly slow PSA doubling time and halt disease progression in the majority of subjects. 1 What is galectin-3 (Gal-3)?MCP may also help with the activation of natural killer cells, as well as T-cytotoxic cells, helping the immune system to fight leukemia [ 11]. MCP is an important component of Complementary and Integrative Medicine (CIM).It hasbeen shown to enhance chemotherapy (even against resistant cancers) whileprotecting healthy cells fromdamagebyradiotherapy. The original and only proven effective form of MCP is prepared with a proprietary, non-GMO enzymatic process controlled by pH and heat, which breaks the long chain molecules of the native pectin to produce the correct molecular size and structure of <13 kilodaltons and <5% esterification. L. Calvier, et al., “The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries,” JACC Heart Fail. 3(1), 59–67 (2015). Galectin-3fuels chronic inflammation andits progressionin the body. It alsoaids tumour growth, metastasis and angiogenesis (new blood vessels thatsupply the tumour).

PectaSol modified citrus pectin is naturally derived from the pith of citrus fruit peels, including lemons, limes and oranges. Sun H, Jiang H, Eliaz A, Kellum JA, Peng Z, Eliaz I. Galectin-3 in septic acute kidney injury: a translational study. Crit Care. 2021 Mar 18;25(1):109. DOI: 10.1186/s13054-021-03538-0. PMID: 33736691. PMCID: PMC7977587. BEST PRICES GUARANTEED on over 2.6 million Hotels Worldwide. Instant confirmation. Book now - pay when you stay. 24/7 customer service. Villas, Apartments B&B too. Save a further 10% with Genius. Induced mitochondrial depolarization, reactive oxygen species generation, caspase-3 and Poly (ADP-ribose) polymerase 1 (PARP1) activation resulting in DNA fragmentationThe observations of PSA stabilization/response and lengthening of PSADT in patients treated with P-MCP are consistent with prior preclinical and clinical data. The extracellular galectin-3 protein participates in the tumorigenesis process by various mechanisms, including inflammation, cellular proliferation, angiogenesis, and progression to an overt metastatic state via cancer cell–endothelial adhesion in distant organs. Elevated galectin-3 serum level was reported in prostate cancer patients [ 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26]. P-MCP is an oral competitive inhibitor of galectin-3, and preliminary preclinical and clinical data suggest that it is active in patients with prostate cancer [ 17, 18]. Induced mitochondrial depolarization, reactive oxygen species generation, caspase-3 and Poly (ADP-ribose) polymerase 1 (PARP1) activation resulting in DNA fragmentation.

PectaSol is the original and only clinically proven Modified Citrus Pectin on the market. With over 80+ peer-reviewed published studies and counting, PectaSol continues to gain recognition as a scientifically substantiated natural solution, delivering powerful benefits for our most critical areas of health - safely and naturally.*Take one 5 gram scoop 3 times daily with liquid on any empty stomach or as recommended by your healthcare practitioner. This product is designed to be taken on an empty stomach, at least 30 minutes before or 2 hours after food, or 2 hours either before or after other supplements or medications. Another randomized control trial concluded that at least 6 grams a day of pectin benefited cholesterol levels [ 6]. This trial also showed that citrus pectin was more effective than pectin derived from apples. PectaSol® Metal Detox provides a safe and effective solution to help reduce the body burden of heavy metals and pollutants found in the diet and environment. People who take PectaSol Metal Detox report improved detoxification results, reduced detoxification side effects, and greater overall wellbeing.*